Characterization of a Novel Murine Retrovirus Mixture That Facilitates Hematopoiesis

Hook, Lauren M.; Jude, Brooke A.; Ter-Grigorov, V. S.; Hartley, Janet W.; Morse, Herbert C.; Trainin, Z.; Toder, V.; Chervonsky, Alexander V.; Golovkina, Tatyana V.

doi:10.1128/jvi.76.23.12112-12122.2002

Cited by 14 publications

(28 citation statements)

References 47 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with previous reports (18)(19)(20)(21), the virus replicated efficiently in GF and SPF BALB/cJ mice, as they developed splenomegaly and carried high viral titers in the spleen (Table 1). Unlike BALB/cJ mice, both virus-resistant GF and SPF BALB/ cJ vic1I/LnJ mice neutralized the virus, as they did not develop splenomegaly and had no detectable virus in the spleen (Table 1).…”

supporting

confidence: 92%

See 1 more Smart Citation

Antibody-Mediated Immune Control of a Retrovirus Does Not Require the Microbiota

Wilks

Beilinson

Theriault

et al. 2014

J Virol

View full text Add to dashboard Cite

cCommensal microbes are often required to control viral infection by facilitating host immune defenses. However, we found that this does not hold true for retroviral infection. We report that retrovirus-resistant mice control the pathogen with virus-neutralizing antibodies independently of commensal microbiota. This is in contrast to orthomyxoviruses and arenaviruses, where resistance is ablated in animals depleted of microbiota. Clearly, when it comes to antiviral immunity, the role of the microbiota cannot be generalized.

show abstract

supporting

confidence: 92%

“…injection of Rauscher-like MuLV (RL-MuLV) (10 3 PFU) (18). RL-MuLV is a mixture of an ecotropic and mink cell focusforming MuLVs capable of causing splenomegaly, which progresses to erythroleukemia in BALB/cJ mice (18). Infected mice were screened for antivirus Abs 9 weeks after infection.…”

mentioning

confidence: 99%

Antibody-Mediated Immune Control of a Retrovirus Does Not Require the Microbiota

Wilks

Beilinson

Theriault

et al. 2014

J Virol

View full text Add to dashboard Cite

show abstract

“…Although many endogenous MuLVs are defective, some are capable of producing infectious particles (Cloyd et al, 1980; Hook et al, 2002; Stoye et al, 1991). I/LnJ mice inherit endogenous MuLVs (Figure S2A), and ecotropic viruses were upregulated in aged I/LnJ mice, as evidenced by the presence of infectious virions in their spleens (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry

et al. 2011

View full text Add to dashboard Cite

SUMMARY Innate immune sensors are required for induction of pathogen-specific immune responses. Retroviruses are notorious for their ability to evade immune defenses and establish long-term persistence in susceptible hosts. However, some infected animals are able to develop efficient virus-specific immune responses, and thus can be employed for identification of critical innate virus-sensing mechanisms. With mice from two inbred strains that control retroviruses via adaptive immune mechanisms, we found that of all steps in viral replication, the ability to enter the host cell was sufficient to induce antivirus humoral immune responses. Virus sensing occurred in endosomes via a MyD88-Toll-like receptor 7-dependent mechanism and stimulated virus-neutralizing immunity independently of type I interferons. Thus, efficient adaptive immunity to retroviruses is induced in vivo by innate sensing of the early stages of retroviral infection.

show abstract

“…Rauscher-like MuLV (RL-MuLV), a mixture consisting of NB-tropic, ecotropic and mink lung cell focus-forming viruses, was described previously (Hook et al, 2002). The virus was propagated in BALB/cJ mice and was isolated from spleens of chronically infected animals.…”

Section: Star Methodsmentioning

confidence: 99%

Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob

et al. 2017

Self Cite

View full text Add to dashboard Cite

SUMMARY Select humans and animals control persistent viral infections via adaptive immune responses that include production of neutralizing antibodies. The precise genetic basis for the control remains enigmatic. Here, we report positional cloning of the gene responsible for production of retrovirus-neutralizing antibodies in mice of the I/LnJ strain. It encodes the beta subunit of the non-classical Major Histocompatibility Complex class II (MHC-II)-like molecule H2-O, a negative regulator of antigen presentation. The recessive and functionally null I/LnJ H2-Ob allele supported the production of virus-neutralizing antibodies independently of the classical MHC haplotype. Subsequent bioinformatics and functional analyses of the human H2-Ob homologue, HLA-DOB revealed both loss- and gain-of-function alleles, which could affect the ability of their carriers to control infections with Human Hepatitis B (HBV) and C (HCV) viruses. Thus, understanding of the previously unappreciated role of H2-O (HLA-DO) in immunity to infections may suggest new approaches in achieving neutralizing immunity to viruses.

show abstract

Characterization of a Novel Murine Retrovirus Mixture That Facilitates Hematopoiesis

Cited by 14 publications

References 47 publications

Antibody-Mediated Immune Control of a Retrovirus Does Not Require the Microbiota

Antibody-Mediated Immune Control of a Retrovirus Does Not Require the Microbiota

Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry

Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob

Contact Info

Product

Resources

About