Characterization of a novel model for investigation of radiocontrast nephrotoxicity

Harmon, R. Christopher; Duffy, Scott P.; Terneus, Marcus; Ball, John G.; Valentovic, Monica

doi:10.1093/ndt/gfn540

Cited by 14 publications

(5 citation statements)

References 21 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An additional confounder was the significant decrease in concentrations between 72 hours before and 72 hours after the second contrast injection (82.6 vs. 68 μmol/L, respectively) when most human studies show an increase 24–72 hours following exposure [8,9,12,13,16-18]. Creatinine concentrations have been reported to peak up to 96 hours post contrast administration and a possible elevation may theoretically have been missed [19]. Fortunately CIN is usually self limiting and if an elevation occurred this usually returns to near baseline values within 1–3 weeks [17] making the 6 weeks later elevation also unlikely to be clinically significant.…”

Section: Discussionmentioning

confidence: 99%

“…In most cases this rise has been reported to occur 24–72 hours following exposure [8,9,12,13,16-18]. One publication cited that the creatinine levels peaked at 96 hours post contrast administration and thus CIN may be overlooked or underestimated in studies measuring creatinine concentrations at 48 hours or less [19]. Fortunately, CIN is usually self limiting with serum creatinine levels returning to near baseline values within 1–3 weeks [17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

et al. 2012

View full text Add to dashboard Cite

BackgroundContrast induced nephrotoxicity (CIN) is a well described syndrome in humans undergoing contrast medium examinations. To date CIN has received minimal attention in the veterinary literature despite increasing use of contrast medium examinations in computed tomographic studies.MethodsThis prospective study evaluated the effect of 1290 mg/kg iohexol given intravenously to 5 normal beagle dogs in a divided dose at an interval of 6–8 weeks. Renal function was evaluated by means of scintigraphically determined glomerular filtration rate (GFR) and a variety of laboratory assays.ResultsOnly GFR showed a significant decrease (17%) after the second injection but not to a clinically or pathologically significant level.ConclusionsNo clinically significant effect of repeated contrast medium administration was determined in this limited study. However in dogs with reduced renal function the risk of CIN is likely to increase dramatically post contrast administration.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Different types of high-osmolar CM were studied in renal cortical cells isolated from male Fischer 344 rats (Table 1). CM was shown to induce renal cell injury in a dose-dependent manner regardless of type of high-osmolar CM [18]. In human embryonic kidney 293 T cells, CM activated JNK/activating transcriptional factor 2 (ATF2) signaling pathways and decreased cell viability.…”

Section: Roles Of Mitogen-activated Protein Kinase (Mapk) Pathways Inmentioning

confidence: 99%

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Kusirisin

Chattipakorn

2020

J Transl Med

View full text Add to dashboard Cite

Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) is an iatrogenic acute kidney injury observed after intravascular administration of contrast media for intravascular diagnostic procedures or therapeutic angiographic intervention. High risk patients including those with chronic kidney disease (CKD), diabetes mellitus with impaired renal function, congestive heart failure, intraarterial intervention, higher volume of contrast, volume depletion, old age, multiple myeloma, hypertension, and hyperuricemia had increased prevalence of CIN. Although CIN is reversible by itself, some patients suffer this condition without renal recovery leading to CKD or even end-stage renal disease which required long term renal replacement therapy. In addition, both CIN and CKD have been associated with increasing of mortality. Three pathophysiological mechanisms have been proposed including direct tubular toxicity, intrarenal vasoconstriction, and excessive production of reactive oxygen species (ROS), all of which lead to impaired renal function. Reports from basic and clinical studies showing potential preventive strategies for CIN pathophysiology including low- or iso-osmolar contrast media are summarized and discussed. In addition, reports on pharmacological interventions to reduce ROS and attenuate CIN are summarized, highlighting potential for use in clinical practice. Understanding this contributory mechanism could pave ways to improve therapeutic strategies in combating CIN.

show abstract

“…Despite the size of the clinical problem, the pathophysiology of radiocontrast‐induced AKI is unresolved . Direct nephrotoxic effects of radiocontrast agents appear to play some role, but there is also evidence for a crucial role of medullary hypoxia . In anaesthetized rats, medullary tissue P o 2 declines abruptly after radiocontrast administration .…”

Section: Kidney Oxygenation In Specific Forms Of Acute Kidney Injurymentioning

confidence: 99%

Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology

Evans

İnce

Joles

et al. 2013

Clin Exp Pharma Physio

222

239

View full text Add to dashboard Cite

SUMMARY1. Renal blood flow, local tissue perfusion and blood oxygen content are the major determinants of oxygen delivery to kidney tissue. Arterial pressure and segmental vascular resistance influence kidney oxygen consumption through effects on glomerular filtration rate and sodium reabsorption.2. Diffusive shunting of oxygen from arteries to veins in the cortex and from descending to ascending vasa recta in the medulla limits oxygen delivery to renal tissue. Oxygen shunting depends on the vascular network, renal haemodynamics and kidney oxygen consumption. Consequently, the impact of changes in renal haemodynamics on tissue oxygenation cannot necessarily be predicted intuitively and, instead, requires the integrative approach offered by computational modelling and multiple measuring modalities.3. Tissue hypoxia is a hallmark of acute kidney injury (AKI) arising from multiple initiating insults, including ischaemia-reperfusion injury, radiocontrast administration, cardiopulmonary bypass surgery, shock and sepsis. Its pathophysiology is defined by inflammation and/or ischaemia resulting in alterations in renal tissue oxygenation, nitric oxide bioavailability and oxygen radical homeostasis. This sequence of events appears to cause renal microcirculatory dysfunction, which may then be exacerbated by the inappropriate use of therapies common in peri-operative medicine, such as fluid resuscitation.4. The development of new ways to prevent and treat AKI requires an integrative approach that considers not just the molecular mechanisms underlying failure of filtration and tissue damage, but also the contribution of haemodynamic factors that determine kidney oxygenation. The development of bedside monitors allowing continuous surveillance of renal haemodynamics, oxygenation and function should facilitate better prevention, detection and treatment of AKI.

show abstract

Characterization of a novel model for investigation of radiocontrast nephrotoxicity

Cited by 14 publications

References 21 publications

The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

The effects of repeated intravenous iohexol administration on renal function in healthy beagles – a preliminary report

Contrast-induced nephropathy and oxidative stress: mechanistic insights for better interventional approaches

Haemodynamic influences on kidney oxygenation: Clinical implications of integrative physiology

Contact Info

Product

Resources

About