Characterization of a novel alanine-rich protein located in surface microdomains in Trypanosoma brucei. Vol. 275 (2000) 4072-4080

Nolan, Derek P.; Jackson, David G.; Biggs, Mary J.; Brabazon, Elaine D.; Pays, Annette; Laethem, François Van; Paturiaux-Hanocq, Françoise; Elliott, John F.; Voorheis, H. Paul; Pays, Étienne

doi:10.1016/s0021-9258(20)79412-3

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2024

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“…brucei, the parasitic agent of African sleeping sickness, is closely related to T. cruzi. Mitochondria of the BSF of T. brucei are largely repressed and are deficient in the complete set of Krebs cycle and oxidative phosphorylation enzymes (Nolan et al, 2000;Le Febvre & Hill, 1986). Thus, energy is mainly derived via the glycolytic pathway.…”

Section: Introductionmentioning

confidence: 99%

Crystal structure of glycerol kinase from Trypanosoma cruzi, a potential molecular target in Chagas disease

Lipiński,

Sonani,

Dubin

2024

Acta Crystallogr D Struct Biol

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Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. It bears a significant global health burden with limited treatment options, thus calling for the development of new and effective drugs. Certain trypanosomal metabolic enzymes have been suggested to be druggable and valid for subsequent inhibition. In this study, the crystal structure of glycerol kinase from T. cruzi, a key enzyme in glycerol metabolism in this parasite, is presented. Structural analysis allowed a detailed description of the glycerol binding pocket, while comparative assessment pinpointed a potential regulatory site which may serve as a target for selective inhibition. These findings advance the understanding of glycerol metabolism in eukaryotes and provide a solid basis for the future treatment of Chagas disease.

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Section: Introductionmentioning

confidence: 99%