Characterization of a new DQB1 allele (DQB1*0610) which differs from DQB1*0602 at the highly polymorphic 57‐codon

Mersch, G.; Sémana, G.; Canck, I. De; Jannes, Geert; Rombout, A; Sterker, G.; Rossau, R.

doi:10.1111/j.1399-0039.1996.tb02633.x

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1997

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Cited by 6 publications

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“…However, since initial reports of DQBl typing by PCR-SSP (8)(9)(10)(11)(12), there has been a prodigious expansion of recognized alleles, not all of which can be discriminated by existing methods. In particular, seven DQB1*03 and 13 DQB1*06 alleles have now been described (1, [13][14][15][16][17]. We have improved the methods described by Olerup et al (9), and Bunce et al (8,18), so that all recognized alleles, except for synonymous variants, may be distinguished.…”

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confidence: 99%

High‐resolution HLA‐DQB1 typing using the polymerase chain reaction and sequence‐specific primers

Mullighan

Bunce

1997

Tissue Antigens

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Polymorphism at HLA-DQB1 is known to influence tissue compatibility and disease susceptibility; however, current DQB1 typing methods are unable to distinguish the 32 currently recognized DQB1 alleles. We have developed a 32-reaction PCR-SSP method capable of differentiating all DQB1 alleles that differ in amino acid sequence. This method can resolve all heterozygous combinations of DQB1 alleles, with the exception of several combinations involving alleles not thus far detected in Caucasoid populations.

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