Characterization of a New Disease Syndrome Associated with Porcine Circovirus Type 2 in Previously Vaccinated Herds

Cino‐Ozuna, Ada G.; Henry, Steven C.; Hesse, Richard; Nietfeld, Jerome C.; Bai, Jianfa; Scott, H. Morgan; Rowland, Raymond R. R.

doi:10.1128/jcm.02543-10

Cited by 38 publications

(30 citation statements)

References 30 publications

(31 reference statements)

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“…In PCVAD cases, the lung is one of the primary targets for PCV2 infection. For example, the APE syndrome is associated with massive quantities of PCV2 replication in the lung, which results in pulmonary edema (5). PCV2 antigen in lung is associated with the onset of porcine respiratory disease complex (3,31).…”

Section: Discussionmentioning

confidence: 99%

“…A new syndrome, acute pulmonary edema (APE), is characterized by the rapid onset of respiratory distress followed by death (5). Experimental studies demonstrate that the infection of pigs with porcine circovirus type 2 (PCV2) alone is necessary but not sufficient to induce PCVAD and requires additional cofactors, which can include infection with viruses or bacteria, immune stimulation following vaccination, and the genetics of the host (17,20,21,27,28,33,35).…”

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confidence: 99%

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Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2

Trible

Suddith

Kerrigan

et al. 2012

J Virol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2

Trible

Suddith

Kerrigan

et al. 2012

J Virol

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“…Porcine circovirus type 2 (PCV2) is the most important pathogen among the PCV2-associated diseases, including post-weaning multisystemic wasting syndrome (PMWS) [1][2][3][4], porcine dermatitis and nephropathy syndrome (PDNS) [5][6][7], reproductive failure, porcine respiratory disease complex (PRDC), granulomatous enteritis, necrotizing lymphadenitis [8], and acute pulmonary edema (APE) [9]. The virus has 11 open reading frames (ORFs), 3 of which have been characterized.…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of porcine alveolar macrophages infected with porcine circovirus type 2

Cheng

Zhang

et al. 2012

Journal of Proteomics

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“…Porcine circovirus type 2 (PCV2) has been linked to various diseases in pigs including postweaning multisystemic wasting syndrome (PMWS) and porcine dermatitis and nephropathy syndrome (PDNS), collectively named as porcine circovirus-associated disease (PCVADs), causing significant economic problems in swine industry worldwide [12,13,14]. As a member of the family Circoviridae, genus Circovirus, PCV2 has small nonenveloped icosahedral virus shell with a single-stranded circular DNA genome inside.…”

Section: Whole Virus Simulationmentioning

confidence: 99%

Two-phase flow analogy as an effective boundary condition for modelling liquids at atomistic resolution

Korotkin

Nerukh

Tarasova

et al. 2016

Journal of Computational Science

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Two-phase flow analogy as an effective boundary condition for modelling liquids at atomistic resolution, Journal of Computational Science http://dx.doi.org/10. 1016/j.jocs.2016.03.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HighlightsWe have recently suggested and implemented a new approach to the problem of computing liquids at multiple scales in space and time based on the two-phase hydrodynamics analogy. Instead of separating the system into parts using boundaries, in the current hybrid approach the liquid is described as a nominally two-phase system consisting of both particle and continuum at the same time and using the continuum part of the model as an effective opendomain boundary condition for atomistic simulations. For the current paper, the method has been extended to dynamically tracking the atomistic-resolution features of interest which can evolve in the flow. Simulations of two very different biomolecular systems have been performed using our hybrid method implemented in the framework of the popular open-source GROMACS software. For both examples, it has been shown that the hybrid model can preserve important properties of the molecular part of the system. For the problem of peptide diffusion in water, the method has allowed obtaining the value of diffusion coefficient which is very close to that one of the reference all-atom simulation. For the virus in water problem, the method has preserved the structure of the virus capsid despite a relatively thin layer of molecular water around the proteins constituting the capsid, and which is in contrast with the all-atom simulation with the standard periodic boundary conditions. 3 Abstract A hybrid Molecular Dynamics/ Fluctuating Hydrodynamics framework based on the analogy with two-phase hydrodynamics has been extended to dynamically tracking the feature of interest at all-atom resolution. In the model, the hydrodynamics description is used as an effective boundary condition to close the molecular dynamics solution without resorting to standard periodic boundary conditions. The approach is implemented in a popular Molecular Dynamics package GROMACS and results for two biomolecular systems are reported. A small peptide dialanine and a complete capsid of a virus porcine circovirus 2 in water are considered and shown to reproduce the structural and dynamic properties compared to those obtained in theory, purely atomistic simulations, and experiment.

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Characterization of a New Disease Syndrome Associated with Porcine Circovirus Type 2 in Previously Vaccinated Herds

Cited by 38 publications

References 30 publications

Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2

Recognition of the Different Structural Forms of the Capsid Protein Determines the Outcome following Infection with Porcine Circovirus Type 2

Proteomic analysis of porcine alveolar macrophages infected with porcine circovirus type 2

Two-phase flow analogy as an effective boundary condition for modelling liquids at atomistic resolution

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