Characterization of a new convolution model for correcting dispersion effects in extracorporeal PET arterial input function measurements in mice

Validation of arterial input function measurements within an extracorporeal shunt driven by mouse blood pressure for preclinical dynamic PET-MRI

“…Methodik/Methods The proposed setup involved extracorporeal shunting from the femoral artery to the tail vein for seven mice experiments using F-18-PSMA-1007, incorporating a blood radioactivity detector (Twilite, SwissTrace). Determination of the AIF was conducted in accordance to the previous study 1 , with dispersion, introduced by the catheters in the setup, being characterized as a sum of two gamma variates 2 . Parametric deconvolution involved fitting AIF and the unknown dispersion kernel simultaneously.…”