Characterization of a new class of transcribed repetitive DNA sequence which also exists as a hybrid with HP1 mRNA; potential for site-specific recombination in drosophila melanogaster

Ngan, Vivian K.; Vacano, Guido N.; Bond, Ursula; James, Tharappel C.

doi:10.1016/0965-1748(94)00069-t

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1999

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“…5. Tissue-specific recombination has been proposed as a mechanism for generating hybrid transcripts in Drosophila (26), but is unlikely to account for SA exon repetition because the Southern blots of PT segment DNA show no evidence of novel junctions flanking any potential duplication (Fig. 6d).…”

Section: Discussionmentioning

confidence: 99%

Exon repetition in mRNA

Frantz

Thiara²,

Lodwick³

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

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The production of different transcripts (transcript heterogeneity) is a feature of many genes that may result in phenotypic variation. Several mechanisms, that occur at both the DNA and RNA level have been shown to contribute to this transcript heterogeneity in mammals, all of which involve either the rearrangement of sequences within a genome or the use of alternative signals in linear, contiguous DNA or RNA. Here we describe tissue-specific repetition of selective exons in transcripts of a rat gene (SA) with a normal exon-intron organization. We conclude that nonlinear mRNA processing can generate tissue-specific transcripts.

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Section: Discussionmentioning

confidence: 99%