“…However, the titanium alloys currently in use also exhibit a high elastic modulus (110 GPa) in comparison to that of the human bone elastic modulus (10-30 GPa), fact that may cause the stress-shielding phenomenon and result in the premature failure of the implant; This factor, in turn, is considered to be a major cause of revision surgeries (Zhou and Luo, 2011;Zhou and Niinomi, 2009;Zhentao and Lian, 2006;Hao et al, 2006). As a result, during the last decades, increasing attention has been given to the development of new type-ȕ titanium alloys, they are assumed to be possible substitutes for the most widely used alloy in orthopedic applications -Ti-6Al-4V alloy (Niinomi et al, 2012;Gabriel et al, 2012;Kim et al, 2006a;Guo et al, 2010;Lopes et al, 2011). In this context, Nb addition to titanium alloys has become common because of its biological passivity and capability to reduce the elastic modulus (Lopes et al, 2011;Cremasco et al, 2011;Afonso et al, 2007).…”