Characterization of a miniature, ultra-high-field, ion mobility spectrometer

Wilks, Ashley T; Hart, Matthew; Koehl, Andrew; Somerville, John; Boyle, Billy; Ruiz-Alonso, David

doi:10.1007/s12127-012-0109-x

Cited by 34 publications

(51 citation statements)

References 34 publications

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“…Loss of valine ions appears to be an example of this as all DMS cells showed a sharp decrease in valine ion current when operated above 125 Td, with complete loss observed above 150 Td. This Bfield heating effect^has been described in detail by Wilks et al [24], suggesting that the effective ion temperature scales approximately with the square of separation field. The fundamental limit to the separation field strength will be determined by the bond strength for organic ions, and it appears that many compounds may be susceptible to fragmentation with field strengths greater than 250 Td.…”

Section: Resultssupporting

confidence: 54%

“…This phenomenon has been taken advantage of in order to improve separations for small gap height devices by increasing their separation fields to the maximum sustainable values [14,24]. Table 2 shows the maximum separation field that we could sustain before discharge with 4 of the DMS cells.…”

Section: Resultsmentioning

confidence: 99%

“…For systems that operate within a narrowly confined E/N range, further truncation of Eq. 4 to 2 terms may be possible [5,23], however, this substantially increased the variance between experimental and calculated data, as has been discussed previously [12,24]. A unified approach for alpha determination would provide the possibility for inter laboratory alpha function comparison between different scientific teams.…”

Section: Modeling the Alpha Functionmentioning

confidence: 97%

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Comparison of the peak capacity for DMS filters with various gap height: experimental and simulations results

Schneider

Nazarov

Londry

et al. 2015

Int. J. Ion Mobil. Spec.

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Differential Mobility Spectrometry (DMS) devices have been integrated with mass spectrometers to provide an orthogonal pre-separation for targeted quantitation. The distance between the DMS electrodes, referred to as the gap height, is a critical parameter for optimization of DMS performance. The literature includes descriptions of various atmospheric pressure DMS devices with gap heights spanning a range of approximately 0.035 to 2 mm. However, despite the presence of numerous publications describing different gap height devices, there is no systematic investigation that describes the effect of DMS gap height on separation peak capacity. This paper summarizes the results from experimental investigations of the effect of gap height on analytical performance (peak capacity and speed) for DMS devices with gap heights that range from 100 μm to 1.5 mm. In addition, this manuscript provides computer simulations of ion motion that shed some light on the relationship between DMS gap height, waveform frequency, and ion transmission. In order to provide accurate and precise experimental data for use in the simulations and development of models, a custom waveform generator has been designed to maintain separation waveform shape regardless of the capacitive load of the DMS cell and the separation waveform amplitude. The differential mobility function (alpha) has been calculated from experimentally measured compensation fields with each of the cells. When the experimental conditions were constant for a given compound, all tested cells provided similar alpha functions, confirming that similar separation mechanisms are observed regardless of gap height. On the basis of these comprehensive experimental data, it is suggested that a phenomenological model can be used for prediction of peak position for particular ion species in planar DMS devices with different gap height. A number of examples will be presented illustrating peak capacity and speed for separations at fixed E/N ratios, as well as at the maximum E/N achievable for each differential mobility filter.

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Section: Resultssupporting

confidence: 54%

Section: Resultsmentioning

confidence: 99%

Section: Modeling the Alpha Functionmentioning

confidence: 97%

See 1 more Smart Citation

Comparison of the peak capacity for DMS filters with various gap height: experimental and simulations results

Schneider

Nazarov

Londry

et al. 2015

Int. J. Ion Mobil. Spec.

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“…Notable efforts sprung up among new groups at the Pacific Northwest National Laboratories (PNNL) (Richland, WA) (Shvartsburg, Maskevich, & Smith, ; Shvartsburg & Smith, 2007, 2011a, 2013b; Shvartsburg, ; Shvartsburg, Danielson, & Smith, ; Shvartsburg, Tang, & Smith, ; Shvartsburg et al, ), University of Florida (Rorrer & Yost, 2011; Tsai, Yost, & Garrett, ), University of North Carolina (Ferzoco et al, ; Ridgeway, Remes, & Glish, ; Isenberg, Armistead, & Glish, ), and Northeastern University (Levin et al, ,, ; Hall et al, ,, ; Kafle et al, , ). Work in the field of nanofabrication at the University of Cambridge led to the development of micro machine‐based DMS sensors and the emergence of the company Owlstone (Owlstone Ltd, Cambridge, UK) that has recently launched a DMS for direct coupling to mass spectrometry (Wilks et al, ). Groups from Loughborough University and PNNL demonstrated the utility of this coupling (Shvartsburg et al, ,; Brown et al, , ).…”

Section: Historymentioning

confidence: 99%

Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications

Schneider¹,

Nazarov

Londry³

et al. 2015

Mass Spectrometry Reviews

156

206

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This review of differential mobility spectrometry focuses primarily on mass spectrometry coupling, starting with the history of the development of this technique in the Soviet Union. Fundamental principles of the separation process are covered, in addition to efforts related to design optimization and advancements in computer simulations. The flexibility of differential mobility spectrometry design features is explored in detail, particularly with regards to separation capability, speed, and ion transmission. 2015 Wiley Periodicals, Inc. Mass Spec Rev 35:687-737, 2016.

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“…However, this platform lacked measurement sensitivity due to the filtering nature of FAIMS and ion losses at the interface. Technological advances in the sensitivity of the ultra-FAIMS (μFAIMS) by the Owlstone firm (134, 135) prompted an additional evaluation of FAIMS-DTIMS-MS for 3D analyses of a bovine serum albumin tryptic digest and the separation of isomeric compounds (136). Although μFAIMS greatly improved the sensitivity of measurements, especially when utilizing a helium/nitrogen gas mixture as shown in Figure 6, its small size offered limited resolving power.…”

Section: Field Asymmetric–and Drift Tube Ion Mobility Spectrometry–mamentioning

confidence: 99%

Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses

Zheng

Wojcik

Zhang

et al. 2017

Annual Rev. Anal. Chem.

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Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. Though IMS alone is useful, its coupling with mass spectrometry (MS) and front-end separations is extremely beneficial for increasing measurement sensitivity, peak capacity of complex mixtures, and the scope of molecular information available from biological and environmental sample analyses. In fact, multiple disease screening and environmental evaluations have illustrated that the IMS-based multidimensional separations extract information that cannot be acquired with each technique individually. This review highlights three-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography, supercritical fluid chromatography, liquid chromatography, solid-phase extractions, capillary electrophoresis, field asymmetric ion mobility spectrometry, and microfluidic devices. The origination, current state, various applications, and future capabilities of these multidimensional approaches are described in detail to provide insight into their uses and benefits.

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Characterization of a miniature, ultra-high-field, ion mobility spectrometer

Cited by 34 publications

References 34 publications

Comparison of the peak capacity for DMS filters with various gap height: experimental and simulations results

Comparison of the peak capacity for DMS filters with various gap height: experimental and simulations results

Differential mobility spectrometry/mass spectrometry history, theory, design optimization, simulations, and applications

Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses

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