2002
DOI: 10.1046/j.1432-1033.2002.03296.x View full text |Buy / Rent full text
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Abstract: A new NADP(H)-dependent alcohol dehydrogenase (the YCR105W gene product, ADHVII) has been identified in Saccharomyces cerevisiae. The enzyme has been purified to homogeneity and found to be a homodimer of 40 kDa subunits and a pI of 6.2-6.4. ADHVII shows a broad substrate specificity similar to the recently characterized ADHVI (64% identity), although they show some differences in kinetic properties. ADHVI and ADHVII are the only members of the cinnamyl alcohol dehydrogenase family in yeast. Simultaneous delet… Show more

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“…In Synechocystis, salt stress has been reported to enhance PSI-dependent cyclic electron flow (58) that generates ATP but not NADPH (36), thus participating in determining the ATP/NADPH ratio when photosynthesis operates under changing environmental conditions (45). The fact that AdhA from Synechocystis oxidizes NADPH much more efficiently than it reduces NADP ϩ supports a possible role for this enzyme in oxidizing NADPH under such conditions and thus contributing to the maintenance of the ATP/NADPH balance, as was also previously proposed for two members of the CADH family in Saccharomyces (27,28).…”
Section: Discussionmentioning
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“…In Synechocystis, salt stress has been reported to enhance PSI-dependent cyclic electron flow (58) that generates ATP but not NADPH (36), thus participating in determining the ATP/NADPH ratio when photosynthesis operates under changing environmental conditions (45). The fact that AdhA from Synechocystis oxidizes NADPH much more efficiently than it reduces NADP ϩ supports a possible role for this enzyme in oxidizing NADPH under such conditions and thus contributing to the maintenance of the ATP/NADPH balance, as was also previously proposed for two members of the CADH family in Saccharomyces (27,28).…”
Section: Discussionmentioning
“…Among the most upregulated genes in both strains upon furfural increase from 15 to 25 mM were the oxireductases ADH7, GRE2, OYE3, AAD4, YML131W, YDL124W, OYE2, and GCY1 (see Table S1 in the supplemental material). Six of them prefer NADPH as the cofactor (6,7,21,26,33,44), while for AAD4 and YML131W, the cofactor preference is not known (Saccharomyces Genome Database at http://www.yeastgenome.org). This is consistent with our finding that central carbon metabolism doubles the NADPH-generating pentose phosphate pathway fluxes upon 25 mM furfural challenge.…”
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“…ADH7 encodes a NADPH-dependent, medium-chain-length alcohol dehydrogenase with a broad substrate specificity that includes aromatic compounds. It is a member of the cinnamyl family of alcohol dehydrogenases and is suspected to be involved in the buildup of fusel alcohols (26). Nothing is known about the molecular function or the regulation of ADH7.…”
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“…7) ScADH5 encodes for ScAdh5, and has 76% sequence identity to the ScAdh1 isozyme. 8) ScADH6 and ScADH7 encode for ScAdh6 and ScAdh7 respectively, which show broad substrate specificity 9,10) and are assumed to contribute the maintenance of a proper NADP/NADPH balance.…”
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