Characterization of a Human Respiratory Mucosa Model to Study Odorant Metabolism
Jeanne Mérignac-Lacombe,
Nicole Kornbausch,
Rinu Sivarajan
et al.
Abstract:Nasal xenobiotic metabolizing enzymes (XMEs) are important
for
the sense of smell because they influence odorant availability and
quality. Since the major part of the human nasal cavity is lined by
a respiratory mucosa, we hypothesized that this tissue contributed
to nasal odorant metabolism through XME activity. Thus, we built human
respiratory tissue models and characterized the XME profiles using
single-cell RNA sequencing. We focused on the XMEs dicarbonyl and l-xylulose reductase, aldehyde dehydrogenase (… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.