Characterization of a human placental clearance system to regulate serotonin levels in the fetoplacental unit
Frantisek Staud,
Xin Pan,
Rona Karahoda
et al.
Abstract:Background
Serotonin (5-HT) is a biogenic monoamine with diverse functions in multiple human organs and tissues. During pregnancy, tightly regulated levels of 5-HT in the fetoplacental unit are critical for proper placental functions, fetal development, and programming. Despite being a non-neuronal organ, the placenta expresses a suite of homeostatic proteins, membrane transporters and metabolizing enzymes, to regulate monoamine levels. We hypothesized that placental 5-HT clearance is important… Show more
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