Characterization of a Group B Streptococcus infection based on the demographics, serotypes, antimicrobial susceptibility and genotypes of selected isolates from sterile and non-sterile isolation sites in three major hospitals in Malaysia

Desa, Mohd Nasir Mohd; Eskandarian, Narges; Pillay, S Ganapathy; Ismail, Zawawi Bin; Neela, Vasantha Kumari; Masri, Siti Norbaya; Nordin, Syafinaz Amin

doi:10.1016/j.jiph.2016.01.009

Cited by 22 publications

(20 citation statements)

References 21 publications

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“…Several studies have reported that erythromycin and clindamycin resistance were the most common phenotypes (Jannati et al, 2012; Bolukaoto et al, 2015; Goudarzi et al, 2015; Kuang et al, 2015; Malek-Jafarian et al, 2015; Suhaimi et al, 2016). Since the first CDC guideline had been published in 1996, the frequency of erythromycin-resistant strains increased after a year (Lin et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Since the first CDC guideline had been published in 1996, the frequency of erythromycin-resistant strains increased after a year (Lin et al, 2000). Although previous studies had not reported resistance to penicillin or ampicillin which was the first-line beta-lactam antibiotics, GBS with reduced penicillin susceptibility had been reported (Kimura et al, 2008; Jannati et al, 2012; Seki et al, 2015; Suhaimi et al, 2016). On the other hand, the increasing resistance to the macrolides and clindamycin which used as alternative drugs for penicillin allergic patients should be paid attention, and guideline for these patients need to be further study (Bolukaoto et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Prevention for Maternal Group B Streptococcal Colonization on Neonatal GBS-Related Adverse Outcomes: A Meta-Analysis

Huang

Chen

et al. 2017

Front. Microbiol.

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Maternal colonization with group B Streptococcus (GBS) during pregnancy increases the risk of neonatal infection by vertical transmission. However, it remains unclear whether treating all colonized women during labor exposes a large number of their neonates to possible adverse effects without benefit. We performed a meta-analysis to assess the effect of intrapartum antibiotic prophylaxis on neonatal adverse outcomes. We identified studies by searching several English and Chinese electronic databases and reviewing relevant articles. Data were pooled using fixed-effects or random-effects meta-analysis, and for each outcome both risk ratio (RR) and 95% confidence intervals (95% CIs) were calculated. Fourteen studies (2,051 pregnant women and 2,063 neonates) were included, comprising 13 randomized clinical trials and 1 cohort study. Antibiotic prophylaxis is associated with a significant reduced risk of all cause infections (RR = 0.28, 95% CI = 0.18–0.42), GBS infection (RR = 0.24, 95% CI = 0.13–0.44), early-onset GBS infection (RR = 0.24, 95% CI = 0.13–0.45), non-GBS infections (RR = 0.34, 95% CI = 0.20–0.59), and GBS colonization (RR = 0.10, 95% CI = 0.06–0.16). But no significant reduction was observed in late-onset GBS infection, mortality from early-onset GBS infection or from non-GBS infections. Notably, no significant differences were found between ampicillin and penicillin prevention for neonatal adverse outcomes. Our findings suggest that antibiotic prophylaxis is effective in reducing neonatal GBS colonization and infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antibiotic Prevention for Maternal Group B Streptococcal Colonization on Neonatal GBS-Related Adverse Outcomes: A Meta-Analysis

Huang

Chen

et al. 2017

Front. Microbiol.

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“…Interestingly, it was found to be the most common serotype in southern Ghana, in the first study to report such serotype prevalence in pregnant women from West Africa (47). A number of Malaysian studies observed serotype VII isolates in their cohorts, ranging from 1.7% to 21.4% of serotypes (18,46,48). This supports the observation of intracountry variation that was similarly reported (although not for CPS VII) for serotypes in different regions of Brazil (19).…”

Section: Serotypingmentioning

confidence: 99%

“…VI. Considered one of the rarer serotypes (with VII, VIII, and IX), CPS VI is often reported in Asian countries, in particular Japan (45) and Malaysia (18,46). While global colonization estimates place CPS VI in the minority, this serotype is thought to account for as much as 20% of serotypes observed in Southeast Asian pregnant women (24).…”

Section: Serotypingmentioning

confidence: 99%

“…The RAPD assay has been used in a number of genotyping contexts, such as evolution and genetic relatedness (93), epidemiology (46,94), transmission (95), and isolate variation within individual patients (96)(97)(98). One study examined RAPD profiles of GBS isolates from a number of sites, such as blood, cerebrospinal fluid, and maternal breast milk, in cases of LOD in neonates (n ϭ 4) (96).…”

Section: Random Amplified Polymorphic Dna and Repetitive-sequence-basmentioning

confidence: 99%

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Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

2018

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SUMMARY, or group B streptococcus (GBS), is a major neonatal pathogen. Recent data have elucidated the global prevalence of maternal and neonatal colonization, but gaps still remain in the epidemiology of this species. A number of phenotypic and genotypic classifications can be used to identify the diversity of GBS strains, and some are more discriminatory than others. This review explores the main schemes used for GBS epidemiology and further details the targets for epidemiological surveillance. Current screening practices across the world provide a unique opportunity to gain detailed information on maternal colonizing strains and neonatal disease-causing strains, which is vital for monitoring and therapeutics, if sufficient detail can be extracted. Deciphering which isolates are circulating within specific populations and recording targets within invasive strains are crucial steps in monitoring the implementation of therapeutics, such as vaccines, as well as developing novel therapies against prevalent GBS strains. Having a detailed understanding of global GBS epidemiology will prove invaluable for understanding the pathogenesis of this organism and equipping future prevention strategies for success.

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Streptococcus agalactiae (Group B Streptococcus)

Shabayek

2022

Molecular Typing in Bacterial Infections, Volume I

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Characterization of a Group B Streptococcus infection based on the demographics, serotypes, antimicrobial susceptibility and genotypes of selected isolates from sterile and non-sterile isolation sites in three major hospitals in Malaysia

Cited by 22 publications

References 21 publications

Antibiotic Prevention for Maternal Group B Streptococcal Colonization on Neonatal GBS-Related Adverse Outcomes: A Meta-Analysis

Antibiotic Prevention for Maternal Group B Streptococcal Colonization on Neonatal GBS-Related Adverse Outcomes: A Meta-Analysis

Perinatal Streptococcus agalactiae Epidemiology and Surveillance Targets

Streptococcus agalactiae (Group B Streptococcus)

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