The study re ported in this pa per aimed to in ves ti gate the re sponse of a GAFChromic® HD-V2 film do sim e ter in the dose range be tween 10 and 300 Gy, nor mally used to per form ir ra di a tion tests on elec tronic de vices with a 60 Co gamma-ray irradiator. The well-de fined linear ity of re sponse in terms of absorbance as a func tion of ab sorbed dose, eas i ness of han dling and data anal y sis of ir ra di ated do sim e ters, reproducibility, sta bil ity, and in sen si tiv ity to vis i ble light and most of the en vi ron men tal pa ram e ters, make HD-V2 film a flex i ble, in ex pen sive and re li able dose mea sure ment de vice. The study has shown a fog ging ef fect of the do sim e ter response since its value changes over time. Strat e gies and ad e quate pre cau tions to take into account changes on HD-V2 film phys i cal prop er ties for cal i bra tion and rou tine use in in dus trial ap pli ca tions, with a spe cific ref er ence to ra di a tion test ing of elec tronic de vices, have been discussed.Key words: gafchromic do sim e try, HD-V2 film, gamma-ray ir ra di a tion, dose, elec tronic de vice F. Martorana, et al.: Re sponse of Gafchromic® HD-V2 Film Do sim e ter in .