A novel smart control system based on genetic algorithms (GAs) is proposed in this paper. The system is comprised of three parts: the fiber Bragg grating (FBG) sensor-based sensing network for structural health monitoring, the GA-based location optimizer for sensor arrangement, and the GA-based controller for vibration mitigation under external excitation. To evaluate the performance of the proposed system, an eight-story steel structure was designed specifically to represent a structure with large degrees of freedom. In total 16 FBG sensors were deployed on the structure to implement the concept of a reliable sensing network, and to allow the structure to be monitored precisely under any loading. The advantage of applying a large amount of information from the sensing system is proven theoretically by the GAbased location optimizer. This result greatly supports the recent tendency of distributing sensors around the structure. Two intuitive GA-based controllers are then proposed and demonstrated numerically. It is shown that the structure can be controlled more effectively by the proposed GA-strain controller than by the GA-acceleration controller, which represents the traditional control method. A shaking table test was carried out to examine the entire system. Experimental verification has demonstrated the feasibility of using this system in practice.Earthquakes have always been the most destructive events for buildings and structures. To prevent the extensive losses of life and property during an earthquake, various kinds of control systems have been investigated to alleviate the response of structures under earthquake excitation. Active structural control has always been seen as the most rapid and effective way to control a structure. Since the first active control concept proposed in 1969 [1], different control methods have been proposed to mitigate the structural reaction by hydraulic actuators [2][3][4][5][6][7][8]. For example, a series of research projects on bidirectional control for different building types were conducted by Gupta et al. [9,10]. Their results all demonstrated the advantages of active control.However, the reliability and robustness problem of the active control system were found to be the main bottleneck for implementing it in practice. To solve this quandary, fuzzy logic and neural networks were considered for their fault-tolerant ability for the active control system. The first active control system combining neural networks was proposed by Ghaboussi and Joghataie in 1995 [11]. Lots of research concerning fuzzy logic and neural networks were then conducted over the next decades [12][13][14][15]. Although the reliability of the active control system has been improved theoretically, the development of the active structural control is still confined to theory and cannot be implemented in practice.The light weight, fast transmission speed, and their characteristic of being immune to electromagnetic waves have proven that fiber Bragg grating (FBG) sensors are reliable elements for structu...