1988
DOI: 10.1093/infdis/158.6.1406
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Characterization of a Dexamethasone-Treated Rat Model of Cryptosporidial Infection

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Cited by 67 publications
(36 citation statements)
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“…The minimal dosage of paromomycin exhibiting an anticryptosporidial effect against ileal infection was 200 mg/kg/day, and paromomycin at up to 400 mg/kg/day was found to enhance cecal infection. Although the model that we have used is inspired by the experimental infection previously described and used by Regh et al (17,18), data from the control groups show that ileal infection was less important and cecal infection was more severe in our study. These differences may explain our findings of the efficiency of a lower paromomycin dosage against the ileal infection.…”
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confidence: 65%
“…The minimal dosage of paromomycin exhibiting an anticryptosporidial effect against ileal infection was 200 mg/kg/day, and paromomycin at up to 400 mg/kg/day was found to enhance cecal infection. Although the model that we have used is inspired by the experimental infection previously described and used by Regh et al (17,18), data from the control groups show that ileal infection was less important and cecal infection was more severe in our study. These differences may explain our findings of the efficiency of a lower paromomycin dosage against the ileal infection.…”
mentioning
confidence: 65%
“…In the present study, a corticosteroid immunosuppression procedure was adapted from rat cryptosporidiosis models since no infection was obtained in immunocompetent gerbils (data not shown) (6,30). This differs from other intestinal protozoal pathogen infections, to which immunocompetent adult gerbils were found experimentally to be at least partially permissive, including Cryptosporidium muris with protracted chronic infections in methylprednisolone immunosuppressed animals (18).…”
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confidence: 90%
“…Dexamethasone (DEX) (Sigma Chemical Co., St. Louis, Mo.) was administered in the drinking water at a concentration equivalent to 0.25 ,ug/g/day (12). The immunosuppressant was administered for 10 days before intragastric inoculation with oocysts, except for an initial experiment in which the drug was administered for 7 days.…”
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confidence: 99%