Characterization of a developing lumbar arthrodesis in a sheep model with quantitative instability

Foster, Mark R.; Allen, Matthew J.; Schoonmaker, Joanne; Yuan, Hansen A.; Kanazawa, Atsunori; Park, Soo-An; Liu, Baowei

doi:10.1016/s1529-9430(02)00189-4

Cited by 21 publications

(15 citation statements)

References 18 publications

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“…8,15 The capacity for induction and acceleration of bone formation in the decorticated areas has been experimentally observed. 4,5 Histological studies with vascular neoformation markers indicate that the initial vascular supply to the arthrodesis mass originates from the decorticated transverse processes and not from the adjacent soft tissues. 16 This is allegedly the explanation for greater bone neoformation in the group of decorticated animals.…”

Section: Discussionmentioning

confidence: 99%

“…2,3 Decortication raises tissue metabolism at the interface through the increase of vascular flow to this region, accelerating the integration of the bone graft to the receptor bed, and triggering greater bone neoformation. 2,4 Although several studies demonstrate the effect of receptor bed decortication on bone graft integration, [5][6][7] the mechanisms involved in the osteogenesis of the receptor bed-graft interface are not totally clear. The aim of this study was to determine the influence of posterior element decortication on bone graft integration, considering the quantitative and qualitative evaluation of the tissues (bone, cartilaginous and fibrous) present at the interface.…”

Section: Introductionmentioning

confidence: 99%

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Influência da decorticação vertebral na neoformação dos tecidos da interface do enxerto ósseo

et al. 2010

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OBJETIVO: Determinar a influência da decorticação dos elementos posteriores da coluna vertebral na integração do enxerto ósseo, considerando a avaliação quantitativa e qualitativa dos tecidos (ósseo, cartilaginoso e fibroso) da interface entre o leito receptor e o enxerto ósseo. MÉTODOS: Foram utilizados 24 ratos Wistar, divididos em dois grupos de acordo com a realização da decorticação do leito receptor do enxerto. Foi utilizado enxerto autólogo derivado dos processos espinhosos das duas primeiras vértebras lombares. A neoformação tecidual na interface entre o leito receptor e seu enxerto ósseo foi avaliada após três semanas por meio de análise histomorfométrica. RESULTADOS: No grupo de animais com o leito receptor decorticado a média da porcentagem de osso neoformado foi de 40%±6,1, e 7,7%± 3,5 no grupo não decorticado (p=0,0001). A média da porcentagem de formação do tecido cartilaginoso no grupo decorticado foi de 7,2%±3,5, no não decorticado de 10,9%±5,6 (p=0,1123). A formação de tecido fibroso no grupo decorticado apresentou média de 8,6%±3,9 e no não decorticado e 24%±10,1, (p=0,0002). CONCLUSÕES: A decorticação acelerou o processo histológico da integração do enxerto ósseo. Ocorrendo maior produção de tecido ósseo neoformado e predomínio da ossificação do tipo intramembranosa no grupo de animais nos quais a decorticação foi realizada.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Influência da decorticação vertebral na neoformação dos tecidos da interface do enxerto ósseo

et al. 2010

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“…The ability of induction and acceleration of bone formation in decorticated areas has been observed experimentally [6,8].…”

Section: Discussionmentioning

confidence: 99%

“…These factors stimulate both the recruitment of more osteogenic cells and neovascularization [12]. The greater quantity of neoformed bone tissue with a smaller amount of cartilage and fibrous tissue in the interface of the decorticated groups appears to be more advantageous for bone graft integration since the bone bridge is formed more rapidly, guaranteeing greater resistance for bone graft integration [8]. Decortication modified not only the quantity of neoformed tissues but also the osteogenesis process for bone graft integration.…”

Section: Discussionmentioning

confidence: 99%

“…Decortication increases tissue metabolism in the interface between bone graft and recipient bed by increasing the vascular supply to this region, accelerating bone graft integration with the recipient bed and triggering greater bone neoformation [4,6]. The effect of decortication on bone graft integration has been observed in previous studies [8,10,13], although the mechanisms involved in osteogenesis in the interface between recipient bed and graft have not been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

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Influence of decortication of the recipient graft bed on graft integration and tissue neoformation in the graft-recipient bed interface

Canto¹,

Garcia

Issa³

et al. 2008

Eur Spine J

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The objective of the present study was to assess the influence of decortication of the posterior elements of the vertebra (recipient bed) and the nature of the bone graft (cortical or cancellous bone) on graft integration and bone, cartilage and fiber neoformation in the interface between the vertebral recipient bed and the bone graft. Seventy-two male Wistar rats were divided into four experimental groups according to the presence or absence of decortication of the posterior vertebral elements and the use of a cortical or cancellous bone graft. Group I-the posterior elements were decorticated and cancellous bone used. Group II-the posterior elements were decorticated and cortical graft was used. Group III-the posterior elements were not decorticated and cancellous graft was used. Group IV-the posterior elements were not decorticated and cortical graft was used. The animals were killed 3, 6 and 9 weeks after surgery and the interface between the posterior elements and the bone graft was subjected to histomorphometric evaluation. Mean percent neoformed bone was 40.8% in group I (decortication and cancellous graft), 39.13% in group II (decortication and cortical graft), 6.13% in group III (non-decorticated and cancellous graft), and 9.27% in group IV (non-decorticated and cortical graft) for animals killed at 3 weeks (P = 0.0005). For animals killed at 6 weeks, the mean percent was 38.53% for group I, 40.40% for group II, 10.27% for group III, and 7.6% for group IV (P = 0.0005), and for animals killed at 9 weeks, the mean was 25.93% for group I, 30.6% for group II, 16.4% for group III, and 18.73% for group IV (P = 0.0026). The mean percent neoformed cartilage tissue was 8.36% for group I, 7.46% for group II, 11.1% for group III, and 9.13% for group IV for the animals killed at 3 weeks (P = 0.6544); 6.6% for group I, 8.07% for group, 7.47% for group III and 6.13% for group IV (P = 0.4889) for animals killed at 6 weeks, and 3.13% for group I, 4.06% for group II, 10.53% for group III and 12.07% for group IV (P = 0.0006) for animals killed at 9 weeks. Mean percent neoformed fibrous tissue was 11% for group I, 6.13% for group II, 26.27% for group III and 21.87% for group IV for animals killed at 3 weeks (P = 0.0008); 7.67% for group I, 7.1% for group II, 9.8% for group III and 10.4% for group IV (P = 0.7880) for animals killed at 6 weeks, and 3.73% for group I, 4.4% for group II, 6.67% for group III and 6.8% for group IV (P = 0.0214) for animals killed at 9 weeks. The statistically significant differences in percent tissue formation were related to decortication of the posterior elements. The use of a cortical or cancellous graft did not influence tissue neoformation. Ossification in the interface of the recipient graft bed was of the intramembranous type in the decorticated animals and endochondral type in the nondecorticated animals.

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Biomechanical role of osteoporosis in the vibration characteristics of human spine after lumbar interbody fusion

Guo

2020

Numer Methods Biomed Eng

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Lumbar vertebrae osteoporosis is the most common challenge for lumbar interbody fusion, and this challenge has been widely concerned by scholars for many years. However, under whole-body vibration, osteoporosis how to affect the vibration characteristics of the fusion lumbar spine, complications, and fusion outcomes is urgent to know. The L1-L5 finite element model of lumbar spine was modified to simulate the transforaminal lumbar interbody fusion model with the bilateral pedicle screw fixator at L4-L5 level. A 5 Hz, 40 N sinusoidal vertical load supplemented with a 400 N preload was used to simulate the vertical vibration of human body. The results showed that under wholebody vibration, osteoporosis of fused vertebrae may cause the adjacent segments more unstable and increase the risk of adjacent segment diseases, subsidence, cage failure, rod failure, and lumbar instability. Osteoporosis of the fused vertebrae may cause the vertebral cells an unstable, inhibited growth and lead to poorer fusion outcomes. The findings may assist us in understanding the effect of osteoporosis on the vibration characteristics of lumbar spine fusion and provide references to clinical treatments for lumbar interbody fusion and lumbar vertebrae osteoporosis.

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Characterization of a developing lumbar arthrodesis in a sheep model with quantitative instability

Cited by 21 publications

References 18 publications

Influência da decorticação vertebral na neoformação dos tecidos da interface do enxerto ósseo

Influência da decorticação vertebral na neoformação dos tecidos da interface do enxerto ósseo

Influence of decortication of the recipient graft bed on graft integration and tissue neoformation in the graft-recipient bed interface

Biomechanical role of osteoporosis in the vibration characteristics of human spine after lumbar interbody fusion

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