Characterization of a cytoplasmic 2-Cys peroxiredoxin from Citrus sinensis and its potential role in protection from oxidative damage and wound healing

Gupta, Deena Nath; Rani, Ruchi; Kokane, Amol; Ghosh, Dilip K.; Tomar, Shailly; Sharma, Ashwani

doi:10.1016/j.ijbiomac.2022.04.086

Cited by 8 publications

(3 citation statements)

References 53 publications

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“… 40 Some researchers reviewed that, reducing the level of reactive oxygen species (ROS) may help alleviate the level of anxiety. 41 Experiments showed that quercetin alleviated anxiety caused by methamphetamine by reducing the level of ROS, mitochondrial membrane potential, increasing oxygen consumption rate, and adenosine triphosphate production. 42 Kaempferol is a flavonoid antioxidant that suppresses the production of reactive oxygen species, regulates endogenous antioxidants such as superoxide dismutase and glutathione, suppresses the formation and aggregation of β-amyloid (β-A), and regulates brain-derived neurotrophic factor to protect the brain.…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology analysis of a patented Chinese herbal medicine for alleviating anxiety disorder in in vitro fertilization-embryo transfer

Liu,

Hu,

Feng

et al. 2024

Journal of Traditional and Complementary Medicine

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Section: Discussionmentioning

confidence: 99%

Network pharmacology analysis of a patented Chinese herbal medicine for alleviating anxiety disorder in in vitro fertilization-embryo transfer

Liu,

Hu,

Feng

et al. 2024

Journal of Traditional and Complementary Medicine

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“…Finally, a group of proteins shows antioxidant properties. High ROS scavenging ability has been found for recombinant 2-Cys peroxiredoxin from Citrus sinensis in Vero cells, heterologous ferredoxin-NADP reductase in Cos-7 cells, and recombinant peptidylprolyl cis-trans isomerase from Pyropia yezoensis in HepG2 cells [ 87 , 88 , 89 ]. On the other hand, the protective effect of glutathione reductase, glutathione transferase, and superoxide dismutase against oxidative damages is well-known [ 90 , 91 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Cytotoxic Effect of Aqueous Extracts from Leaves and Rhizomes of the Seagrass Posidonia oceanica (L.) Delile on HepG2 Liver Cancer Cells: Focus on Autophagy and Apoptosis

Abruscato

Chiarelli

Lazzara

et al. 2023

Biology

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Aqueous extracts from Posidonia oceanica’s green and brown (beached) leaves and rhizomes were prepared, submitted to phenolic compound and proteomic analysis, and examined for their potential cytotoxic effect on HepG2 liver cancer cells in culture. The chosen endpoints related to survival and death were cell viability and locomotory behavior, cell-cycle analysis, apoptosis and autophagy, mitochondrial membrane polarization, and cell redox state. Here, we show that 24 h exposure to both green-leaf- and rhizome-derived extracts decreased tumor cell number in a dose–response manner, with a mean half maximal inhibitory concentration (IC50) estimated at 83 and 11.5 μg of dry extract/mL, respectively. Exposure to the IC50 of the extracts appeared to inhibit cell motility and long-term cell replicating capacity, with a more pronounced effect exerted by the rhizome-derived preparation. The underlying death-promoting mechanisms identified involved the down-regulation of autophagy, the onset of apoptosis, the decrease in the generation of reactive oxygen species, and the dissipation of mitochondrial transmembrane potential, although, at the molecular level, the two extracts appeared to elicit partially differentiating effects, conceivably due to their diverse composition. In conclusion, P. oceanica extracts merit further investigation to develop novel promising prevention and/or treatment agents, as well as beneficial supplements for the formulation of functional foods and food-packaging material with antioxidant and anticancer properties.

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“…This process is a natural and protective response from the body to stressors; however, it usually causes discomfort 154 . Keratinases could replace the salicylic acid, commonly used in the treatment of calluses, in a sustainable manner 155 . Hyperkeratosis is also present in epidermolysis bullosa simplex with mottled pigmentation—a disease characterized by punctate hyperkeratosis of the palms, soles and dystrophic nails 156 —and other conditions such as bullous congenital icthyosiform erythroderma, ichthyosis bullosa of siemens, epidermolytic palmoplantar keratoderma, monilethrix, etc 157 .…”

Section: Proteasesmentioning

confidence: 99%

Enzymes for dermatological use

Nascimento,

Torres‐Obreque,

Oliveira

et al. 2024

Experimental Dermatology

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Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharmaceutical sectors aims to improve skin conditions and provide new anti‐ageing treatments. Biomolecules, compared to low molecular weight drugs and cosmetic ingredients, can offer high levels of specificity. Topically applied enzymes have been investigated to treat the adverse effects of sunlight, pollution and other external agents. Enzymes, with a diverse range of targets, present potential for dermatological use such as antioxidant enzymes, proteases and repairing enzymes. In this review, we discuss enzymes for dermatological applications and the challenges associated in this growing field.

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Characterization of a cytoplasmic 2-Cys peroxiredoxin from Citrus sinensis and its potential role in protection from oxidative damage and wound healing

Cited by 8 publications

References 53 publications

Network pharmacology analysis of a patented Chinese herbal medicine for alleviating anxiety disorder in in vitro fertilization-embryo transfer

Network pharmacology analysis of a patented Chinese herbal medicine for alleviating anxiety disorder in in vitro fertilization-embryo transfer

In Vitro Cytotoxic Effect of Aqueous Extracts from Leaves and Rhizomes of the Seagrass Posidonia oceanica (L.) Delile on HepG2 Liver Cancer Cells: Focus on Autophagy and Apoptosis

Enzymes for dermatological use

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