Characterization of a Circulating Antigen Involved in Immune Complexes in Visceral Leishmaniasis Patients

Mary, Charles; Ange, G; Dunan, S.; Lamouroux, D; Quilici, M

doi:10.4269/ajtmh.1993.49.492

Cited by 19 publications

(10 citation statements)

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“…Apart from being useful in diagnosis of disease, the antibody response in VL patients does not appear to be of benefit to the patient. There are several clinical case reports of autoantibody production and immune complex formation in VL patients [70][71][72][73]. Signs of autoreactivity, such as vasculitis [74,75] and decreased renal function [76,77], have been observed.…”

Section: Regulatory T Cells In Vlmentioning

confidence: 99%

Interleukin-10 and the pathogenesis of human visceral leishmaniasis

Nylén

Sacks

2007

Trends in Immunology

335

298

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Section: Regulatory T Cells In Vlmentioning

confidence: 99%

Interleukin-10 and the pathogenesis of human visceral leishmaniasis

Nylén

Sacks

2007

Trends in Immunology

335

298

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“…Immune complexes consisting of Leishmaniaspecific antibodies and Leishmania antigens can be demonstrated in the blood of VL patients (Kharazmi et al 1982, Mary et al 1993).…”

Section: B Cells B-cells Cannot Be Infected By Leishmania Parasites Bmentioning

confidence: 99%

Regulator and effector functions of T‐cell subsets in human Leishmanaia infections

Kemp

1997

APMIS

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“…In contrast, there is a marked humoral response in VL patients, including both non‐specific immunoglobulins, due to polyclonal B cell activation, and specific anti‐ Leishmania antibodies. The available evidence argues against a protective role of anti‐ Leishmania antibodies in controlling infection and favours the idea that they are involved in the formation of immune complexes [7], which may be detrimental to the host. Deposits of such immune complexes have been observed on different filtration barriers of Leishmania ‐infected animals and they have been suggested to be responsible for several pathologies such as the glomerulonephritis observed during VL [8–10].…”

Section: Introductionmentioning

confidence: 99%

Antigenicity of theLeishmania infantumhistones H2B and H4 during canine viscerocutaneous leishmaniasis

Soto

Requena

Quijada

et al. 1999

Clinical and Experimental Immunology

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SUMMARYIn this study we show that sera from dogs naturally infected with Leishmania infantum contain antibodies that specifically react against the parasite H2B and H4 histones. The Leishmania H2B and the amino-terminal region of the histone H4, expressed as fusion proteins, when confronted with sera from canine viscerocutaneous leishmaniasis (VCL) dogs, were recognized by 63% and 47%, respectively. No reactivity was detected when sera from dogs naturally infected with pathogens other than Leishmania were used. Using a collection of synthetic peptides covering the complete sequence of both proteins, we have determined that the main linear antigenic determinants are located in the amino-terminal domains of these histones. The humoral response against histones H2B and H4 induced during canine leishmaniasis was found to be specific for Leishmania histones, since no cross-reactivity of the VCL sera with mammal histones was observed. Also, a comparative study of the prevalence of antibodies among VCL sera against the four core histones of L. infantum was performed. Although a large heterogeneity of the humoral responses against these proteins was found, histones H2A and H3 seem to be more prevalent immunogens than histones H2B and H4 during canine natural leishmaniasis. The origin of the anti-histone humoral response and its possible implications in the pathogenesis of Leishmania infection are discussed.

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Characterization of a Circulating Antigen Involved in Immune Complexes in Visceral Leishmaniasis Patients

Cited by 19 publications

References 0 publications

Interleukin-10 and the pathogenesis of human visceral leishmaniasis

Interleukin-10 and the pathogenesis of human visceral leishmaniasis

Regulator and effector functions of T‐cell subsets in human Leishmanaia infections

Antigenicity of theLeishmania infantumhistones H2B and H4 during canine viscerocutaneous leishmaniasis

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