Characterization of a boron neutron capture therapy beam line at the University of Missouri Research Reactor

Brockman, John; Nigg, David W.; Hawthorne, M. Frederick; Lee, M. W.; McKibben, C.

doi:10.1007/s10967-009-0169-5

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…These tests exposed samples of the material to a low flux rate of neutrons (8.4 × 10 8 N/cm 2 /s). The neutron source was developed at the University of Missouri Research Reactor (MURR) and has been utilized for a variety of boron neutron capture research [ 21 , 22 , 23 ]. The irradiation set-up consisted of a layered system to gently compress the polymer interlayer material between a boron nitride plate and an aluminum plate.…”

Section: Surface Treatment Techniquesmentioning

confidence: 99%

Polymeric Interlayer Strengthening with Boron Neutron Capture Radiation Treatment for Laminated Glass

et al. 2023

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Polymer interlayer materials are utilized in laminated glass systems to provide increased resilience from blast incidents. The polymer chains within the interlayer material can benefit from material modifications that increase the crosslinking between adjacent chains. One theorized method of targeted crosslinking is made possible through a boron neutron capture process. This process utilizes neutron radiation that bombards boron material, thus producing emissions of highly energetic particles into the polymer. The method has been experimentally utilized for bulk material processing as well as surface treatment. The surface treatment process has been extensively investigated in this study to manipulate polymers commonly used as interlayer material. Comparison evaluation tests have been completed to show the material behavior change through static tensile loading, dynamic tensile loading, indentation testing, and scratch resistance testing. Results present the specific material behavior changes, effects on different interlayer material, and optimizations for the treatment processes. Data resulting from these tests will expand the understanding of the material behavior changes from treatment techniques and show evidence of the expected crosslinking. This understanding will lead to a quantifiable application of system capacities to improve the future designs of the window and building systems and lead to a safer, more secure, and resilient infrastructure. Polymer treatment by boron neutron capture radiation has produced polymer interlayers with the potential of increased resilience to blast. The research to date has evaluated treated polymers and shown that the hardening and increased elasticity of the material can be initiated through treatment, thus indicating crosslinking behavior. These results show distinct changes in the material behavior, particularly with the EVA interlayer material. The harder surface of the interlayer may resist the cutting of the interlayer surface by glass shards. Scratch resistance was 30% higher and the measured hardness was 100% on treated surfaces. Treated EVA exhibited a 40% higher stress capacity, a 35% higher toughness, and a 40% increase in the elasticity of the material. The overall toughness increase of the treated polymer material allows for a higher energy absorption, and an overall improvement of window performance in blast conditions. The treatment technique can be applied to a variety of window interlayer products for optimal material performance in blast conditions.

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Section: Surface Treatment Techniquesmentioning

confidence: 99%

Polymeric Interlayer Strengthening with Boron Neutron Capture Radiation Treatment for Laminated Glass

et al. 2023

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“…Gamma rays are produced during the BNCT reaction and hydrogen neutron capture [12] . The thermal neutron beam at the MURR contains acceptable levels of fast neutrons and gamma rays remaining after the neutron filters [13] . Fast neutrons produce interact with hydrogen and produce high LET recoil protons through elastic scatter.…”

Section: Introductionmentioning

confidence: 99%

Validation and Comparison of the Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated By Boron-Rich Liposomes in Multiple Murine Tumor Models

Maitz

Khan

Kueffer

et al. 2017

Translational Oncology

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Boron neutron capture therapy (BNCT) was performed at the University of Missouri Research Reactor in mice bearing CT26 colon carcinoma flank tumors and the results were compared with previously performed studies with mice bearing EMT6 breast cancer flank tumors. Mice were implanted with CT26 tumors subcutaneously in the caudal flank and were given two separate tail vein injections of unilamellar liposomes composed of cholesterol, 1,2-distearoyl-sn-glycer-3-phosphocholine, and K[nido-7-CH3(CH2)15–7,8-C2B9H11] in the lipid bilayer and encapsulated Na3[1-(2`-B10H9)-2-NH3B10H8] within the liposomal core. Mice were irradiated 30 hours after the second injection in a thermal neutron beam for various lengths of time. The tumor size was monitored daily for 72 days. Despite relatively lower tumor boron concentrations, as compared to EMT6 tumors, a 45 minute neutron irradiation BNCT resulted in complete resolution of the tumors in 50% of treated mice, 50% of which never recurred. Median time to tumor volume tripling was 38 days in BNCT treated mice, 17 days in neutron-irradiated mice given no boron compounds, and 4 days in untreated controls. Tumor response in mice with CT26 colon carcinoma was markedly more pronounced than in previous reports of mice with EMT6 tumors, a difference which increased with dose. The slope of the dose response curve of CT26 colon carcinoma tumors is 1.05 times tumor growth delay per Gy compared to 0.09 times tumor growth delay per Gy for EMT6 tumors, indicating that inherent radiosensitivity of tumors plays a role in boron neutron capture therapy and should be considered in the development of clinical applications of BNCT in animals and man.

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Nanoscale Materials for Tackling Brain Cancer: Recent Progress and Outlook

Rozhkova

2011

Advanced Materials

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Characterization of a boron neutron capture therapy beam line at the University of Missouri Research Reactor

Cited by 8 publications

References 7 publications

Polymeric Interlayer Strengthening with Boron Neutron Capture Radiation Treatment for Laminated Glass

Polymeric Interlayer Strengthening with Boron Neutron Capture Radiation Treatment for Laminated Glass

Validation and Comparison of the Therapeutic Efficacy of Boron Neutron Capture Therapy Mediated By Boron-Rich Liposomes in Multiple Murine Tumor Models

Nanoscale Materials for Tackling Brain Cancer: Recent Progress and Outlook

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