Characterization of 6-deoxy-6-iodo-D-glucose: A potential new tool to assess glucose transport

Assessment of insulin sensitivity in vivo in control and diabetic mice with a radioactive tracer of glucose transport: [125I]‐6‐deoxy‐6‐iodo‐D‐glucose

“…6-DIG is thus a pure tracer of glucose transport in vitro. Moreover, as 3-OMG, 6-DIG can be used to identify defects in glucose transport stimulation by insulin on a model of adipocytes from diabetic rats and obese mice in vitro [30]. In vivo, mouse biodistribution studies have been performed with 6-DIG and 3-OMG [29].…”

“…Recently, [ 123 I]-6-deoxy-6-iodo-D-glucose (6-DIG) has been obtained, and experiments performed in erythrocytes, newborn rat cardiomyocytes, isolated perfused rat hearts and mice demonstrated that its biological behaviour is similar to that of 3-OMG [28,29]. Moreover, an in vitro study on adipocytes from diabetic rats and obese mice showed that 6-DIG, like 3-OMG, could be used to determine alterations in glucose transport [30].…”

Conformational analysis of 6-deoxy-6-iodo-D-glucose in aqueous solution

“…A forward linear prediction on 1024K in the 13 C dimension enhanced resolution. 1 D TOCSY experiments were recorded using a selective 'e-burp'-shaped pulse (pulse width D 240 ms) on each anomeric proton; the mixing time was incremented from 10 to 100 ms.…”

“…Among these analogues of glucose (1), 6-deoxy-6-iodo-D-glucose (2), has shown the required properties of a tracer of D-glucose transport 1 and we have undertaken an NMR study of 2 2 to determine its conformation in aqueous solution, which could be of help in understanding on structural grounds why and how it mimics glucose. In order to compare the results with those for 1, the spectrum of 1 3 -5 was analysed under identical conditions.…”

Enzymatic production of three 6-deoxy-aldohexoses from l-rhamnose

“…20) 6-Deoxy-6-iodo-D-glucose is used as a tool compound to assess glucose transport, which is of major clinical importance because changes in the glucose transport process occur in a number of different pathologies. 21) Based on their interesting properties, deoxy monosaccharides have become compounds of considerable interest. Unfortunately, however, their characteristics and functions have not been investigated to any great extent because of their rarity.…”