Characterization of 4-Aminobiphenyl-Hemoglobin Adducts in Maternal and Fetal Blood Samples

Myers, Steven R.; Spinnato, Joseph A.; Pinorini-Godly, Maria T.; Cook, C. D.; Boles, B.; Rodgers, G. C.

doi:10.1080/009841096161537

Cited by 42 publications

(31 citation statements)

References 27 publications

(29 reference statements)

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“…Among other chemicals that have been measured in fetal blood from tobacco-exposed pregnancies are the carcinogen metabolites 4-aminobiphenyl-hemoglobin adducts (Coghlin et al, 1991;Myers et al, 1996;Pinorini-Godley and Myers, 1996) and 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone and its glucuronidated metabolite (Lackman et al, 1999).…”

Section: Measures Of Tobacco Exposurementioning

confidence: 98%

Tobacco and pregnancy: Overview of exposures and effects

Rogers

2008

Birth Defects Research Pt C

171

104

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This opening article will review the epidemiology of the effects of cigarette smoking and other forms of tobacco exposure on human development. Sources of exposure described include cigarettes and other forms of smoked tobacco, secondhand (environmental) tobacco smoke, several forms of smokeless tobacco, and nicotine from nicotine replacement therapy. Exposure is immense and worldwide, most of it due to smoking, but in some parts of the world and in some populations, smoking is exceeded by smokeless tobacco use. Nicotine and carbon monoxide exposure are of large concern, but cigarette smoke contains over 4000 chemical constituents and additives including known carcinogens, toxic heavy metals, and many chemicals untested for developmental toxicity. The impact of tobacco on human development will be reviewed. Fertility, conception, survival of the conceptus, most phases and aspects of development studied to date, as well as postnatal survival and health are adversely impacted by maternal tobacco use or exposure. Effects in surviving offspring are probably life-long, and are still being elucidated. It is hoped that this review and those to follow in this issue will serve to keep a focus on the critical and continuing problem of tobacco use impacting human development.

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Section: Measures Of Tobacco Exposurementioning

confidence: 98%

Tobacco and pregnancy: Overview of exposures and effects

Rogers

2008

Birth Defects Research Pt C

171

104

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“…Many proven carcinogens are present in tobacco and tobacco smoke (Hecht, 1999;Hoffmann and Hoffmann, 1997). Tobacco-related compounds have also been detected in human placenta, fetal blood, urine of offspring and in breast milk of smoking mothers (Perlman and Dannenberg, 1942;Everson et al, 1986Everson et al, , 1988Woodward et al, 1986;Hansen et al, 1992;Myers et al, 1996;Pinorini-Godly and Myers, 1996;Arnould et al, 1997;Daube et al, 1997).Previous case -control studies have tended to show weak associations between maternal cigarette smoking during pregnancy and childhood cancers (IARC, 1986;Severson et al, 1993;Tredaniel et al, 1994;Sorahan et al, 1995Sorahan et al, , 1997a Sorahan et al, , b, 2001Klebanoff et al, 1996;Shu et al, 1996). There is somewhat stronger and more consistent evidence for a paternal preconceptional effect, although relative risks in most case -control studies are only just above one (Severson et al, 1993;Shu et al, 1996;Ji et al, 1997;Sorahan et al, 1997b;.…”

mentioning

confidence: 99%

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confidence: 99%

Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study

2003

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There are strong a priori reasons for considering parental smoking behaviour as a risk factor for childhood cancer but case -control studies have found relative risks of mostly only just above one. To investigate this further, self-reported smoking habits in parents of 3838 children with cancer and 7629 control children included in the United Kingdom Childhood Cancer Study (UKCCS) were analysed. Separate analyses were performed for four major groups (leukaemia, lymphoma, central nervous system tumours and other solid tumours) and more detailed diagnostic subgroups by logistic regression. In the four major groups, after adjustment for parental age and deprivation there were nonsignificant trends of increasing risk with number of cigarettes smoked for paternal preconception smoking and nonsignificant trends of decreasing risk for maternal preconception smoking (all P-values for trend 40.05). Among the diagnostic subgroups, a statistically significant increased risk of developing hepatoblastoma was found in children whose mothers smoked preconceptionally (OR ¼ 2.68, P ¼ 0.02) and strongest (relative to neither parent smoking) for both parents smoking (OR ¼ 4.74, P ¼ 0.003). This could be a chance result arising from multiple subgroup analysis. Statistically significant negative trends were found for maternal smoking during pregnancy for all diagnoses together (Po0.001) and for most individual groups, but there was evidence of under-reporting of smoking by case mothers. In conclusion, the UKCCS does not provide significant evidence that parental smoking is a risk factor for any of the major groups of childhood cancers. There are strong a priori reasons for considering parental smoking behaviour as a risk factor for childhood cancer. Many proven carcinogens are present in tobacco and tobacco smoke (Hecht, 1999;Hoffmann and Hoffmann, 1997). Tobacco-related compounds have also been detected in human placenta, fetal blood, urine of offspring and in breast milk of smoking mothers (Perlman and Dannenberg, 1942;Everson et al, 1986Everson et al, , 1988Woodward et al, 1986;Hansen et al, 1992;Myers et al, 1996;Pinorini-Godly and Myers, 1996;Arnould et al, 1997;Daube et al, 1997).Previous case -control studies have tended to show weak associations between maternal cigarette smoking during pregnancy and childhood cancers (IARC, 1986;Severson et al, 1993;Tredaniel et al, 1994;Sorahan et al, 1995Sorahan et al, , 1997a Sorahan et al, , b, 2001Klebanoff et al, 1996;Shu et al, 1996). There is somewhat stronger and more consistent evidence for a paternal preconceptional effect, although relative risks in most case -control studies are only just above one (Severson et al, 1993;Shu et al, 1996;Ji et al, 1997;Sorahan et al, 1997b;. This effect has been attributed to germ-cell mutations during spermatogenesis caused by tobacco products (Wyrobeck, 1993;Wyrobek and Adler, 1996;Woodall and Ames, 1997). Relevant studies are reviewed by Thornton and Lee (1998).The United Kingdom Childhood Cancer Study (UKCCS) is a nationwide population-based...

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“…Nonsmokers had levels of about 20 pg 4-ABP/g hemoglobin; levels in smokers could range from about 140-630 pg 4-ABP/g hemoglobin (268). Even human fetuses had such adducts; in nonsmoking women, fetuses had levels of about 9 pg 4-ABP/g hemoglobin; those from women who smoked had levels of about 75-320 pg 4-ABP/g hemoglobin (269). These data indicate that 4-ABP can cross the placental barrier and bind to fetal hemoglobin (270).…”

Section: Toxic Effectsmentioning

confidence: 96%

Aromatic Nitro and Amino Compounds

Bingham¹,

McGowan²

2012

Patty's Toxicology

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Logically, aromatic nitro and amino compounds should be discussed together because their toxic responses are often similar due to a common metabolic intermediate. Synthetically, amines are generally derived from nitro compounds, but in some cases nitro compounds can be prepared through amines when other methods fail to afford specific compounds. There are good and bad attributes to these types of compounds. Some act as sensitizers and contingent on physical properties may be absorbed through the skin or mucous membranes. They may also cause methemoglobinemia, depending on such factors as the structure and the particular organism. Some members of this class are known as animal and human carcinogens; for humans, the urinary bladder is the most prominent target organ. Nevertheless, these compounds and their derivatives have enlivened our world through their use as dyestuff intermediates or as photographic chemicals, they alleviate pain as components of widely used analgesics, and they cushion or insulate us through their use in flexible and rigid foams. Other important uses include production of pesticides, including herbicides and fungicides, as ingredients in adhesives, paints and coatings, antioxidants, explosives, optical brighteners, rubber ingredients, and as intermediates in many other products.

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Characterization of 4-Aminobiphenyl-Hemoglobin Adducts in Maternal and Fetal Blood Samples

Cited by 42 publications

References 27 publications

Tobacco and pregnancy: Overview of exposures and effects

Tobacco and pregnancy: Overview of exposures and effects

Parental smoking and childhood cancer: results from the United Kingdom Childhood Cancer Study

Aromatic Nitro and Amino Compounds

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