Characterization, nanoparticle self-organization, and Monte Carlo simulation of magnetoliposomes

Abstract

In this work we have developed and implement a new approach for the study of magnetoliposomes using Monte Carlo simulations. Our model is based on interaction among nanoparticles considering magnetic dipolar, van der Waals, ionic-steric, and Zeeman interaction potentials. The ionic interaction between nanoparticles and the lipid bilayer is represented by an ionic repulsion electrical surface potential that depends on the nanoparticle-lipid bilayer distance and the concentration of ions in the solution. A direct comparison among transmission electron microscopy, vibrating sample magnetometer, dynamic light scattering, nanoparticle tracking analysis, and experimentally derived static magnetic birefringence and simulation data allow us to validate our implementation. Our simulations suggest that confinement plays an important role in aggregate formation.

Ferrofluids and bio-ferrofluids: looking back and stepping forward

“…24a, the values of static initial susceptibility of a usual, nonconfined magnetic fluid (MF) and of a system of nanoparticles entrapped in liposomes are compared; the measured values are smaller for the magnetoliposome (ML) sample, but both ML and MF values are higher than that corresponding to the non-interacting Langevin model. The experimental data are close to the calculated values using the Mendelev–Ivanov model 285 for the dipole–dipole interaction parameter λ = 5, 428 the Monte-Carlo simulations corresponding to a strongly interacting magnetic nanoparticle system. The chain distributions for the two cases in Fig.…”

Real-time liver uptake and biodistribution of magnetic nanoparticles determined by AC biosusceptometry

“…Such a decrease in susceptibility has recently been reported for magnetoliposomes, which might be considered a model system for the effect of nanoparticle endocytosis. 58 In contrast, the ESR signal would not drop because the number of unpaired spins, detected by the ESR system, is unaffected by particle organization. Further studies focusing on this parameter and analyzing longer time points are needed for a proper evaluation of this profile.…”

Influence of size polydispersity on magnetic field tunable structures in magnetic nanofluids containing superparamagnetic nanoparticles

“…Brownian dynamics [44], Monte Carlo simulation [45], molecular and stochastic dynamic simulations [46,47], and models based on thermodynamic theory [48].…”