Characterization, mRNA expression profile, subcellular distribution and association analysis with piglet diarrhea of porcine matrix metallopeptidase 7 (pMMP7)

Niu, Buyue; Lü, Ling; Chen, Zhihua; Kou, Mingxing; Yang, Xiuqin; Sun, Yuan; Di, Shengwei; Wang, Xibiao; Cai, Jiancheng; Guo, Dongchun

doi:10.1016/j.gene.2022.146319

Cited by 1 publication

(1 citation statement)

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“…The gene encoding MMP-7 belongs to the gene cluster on chromosome 11 at q21 and q22 [ 131 , 132 ]. The complete coding sequence of MMP-7 is 1094 bp long and encodes 267 amino acids [ 133 ].…”

Section: Matrix Metalloprotease-7 (Mmp-7)mentioning

confidence: 99%

Matrix Metalloproteinases Inhibitors in Cancer Treatment: An Updated Review (2013–2023)

Almutairi,

Kalloush,

Manoon

et al. 2023

Molecules

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Matrix metalloproteinases (MMPs) are identifiable members of proteolytic enzymes that can degrade a wide range of proteins in the extracellular matrix (ECM). MMPs can be categorized into six groups based on their substrate specificity and structural differences: collagenases, gelatinases, stromelysins, matrilysins, metalloelastase, and membrane-type MMPs. MMPs have been linked to a wide variety of biological processes, such as cell transformation and carcinogenesis. Over time, MMPs have been evaluated for their role in cancer progression, migration, and metastasis. Accordingly, various MMPs have become attractive therapeutic targets for anticancer drug development. The first generations of broad-spectrum MMP inhibitors displayed effective inhibitory activities but failed in clinical trials due to poor selectivity. Thanks to the evolution of X-ray crystallography, NMR analysis, and homology modeling studies, it has been possible to characterize the active sites of various MMPs and, consequently, to develop more selective, second-generation MMP inhibitors. In this review, we summarize the computational and synthesis approaches used in the development of MMP inhibitors and their evaluation as potential anticancer agents.

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Section: Matrix Metalloprotease-7 (Mmp-7)mentioning

confidence: 99%