Characterization, dissolution and in vivo evaluation of solid acetazolamide complexes

Mora, María Julia; Tártara, Luis Ignacio; Onnainty, Renée; Palma, Santiago Daniel; Longhi, Marcela R.; Granero, Gladys E.

doi:10.1016/j.carbpol.2013.06.012

Cited by 23 publications

(10 citation statements)

References 24 publications

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“…Hygeia.J.D.Med.6 (2) October 2014; 57-70 Bioavailability enhancement of ziprasidone: optimization of carriers and methods employed 2.1.5. Solvent evaporation method [7][8][9][10][11][12][13] :…”

Section: Kneading Methods 7-13mentioning

confidence: 99%

“…The absorbance of the above dilutions were measured at 319 nm by using UV-Spectrophotometer taking 7.5 phosphate buffer containing 2% SLS as blank. c) Compatibility studies by Infrared spectroscopy [7][8][9][10][11][12][13] Fourier transform infra-red (FTIR) spectra of the pure drug and the physical mixtures were obtained by using Shimadzu FTIR-281 spectrophotometer. The samples were previously ground and mixed thoroughly with potassium bromide, an infrared transparent matrix, at 1:100 (sample: KBr) ratio, respectively.…”

Section: B) Analytical Methodsmentioning

confidence: 99%

“…ii) Drug content Analysis [7][8][9][10][11][12][13] Drug content was determined by dissolving solid dispersion equivalent to 5mg of the ZPR in small quantity of methanol and kept in vertex mixture for 10min. The volume was adjusted to 50mL with 2% SLS in phosphate buffer pH 7.5.…”

Section: Murthy S N Varanasi Et Al D) Evaluation Of Solid Dispersionsmentioning

confidence: 99%

“…iii) In-vitro dissolution studies 2,[7][8][9][10][11][12][13] In-vitro dissolution studies of ziprasidone in pure drug form, solid dispersions were performed by using the 8 stage dissolution rate test apparatus (Lab India, DISSO 2000) with paddle at 50 rpm in 900 mL of distilled water. The dissolution rate was studied by placing ziprasidone pure drug and solid dispersions equivalent to 100 mg of drug.…”

Section: Murthy S N Varanasi Et Al D) Evaluation Of Solid Dispersionsmentioning

confidence: 99%

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2014

Hygeia.J.D.Med.

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Plan:The main objective of the present research work was to enhance the dissolution rate of Ziprasidone by preparing the solid dispersions using different carriers like PVP, PEG 4000, SSG and β-Cyclodextrin. Preface: Ziprasidone is a class-II drug according to Biopharmaceutical Classification System. It is practically insoluble in water and it has dissolution limited bioavailability. So, the present research work it is aimed to improve the dissolution rate through solid dispersion technique which further enhances the bioavailability. Methodology: The solid dispersions were prepared at three ratios (1:1, 1:2 & 1:3) of each carrier by three different techniques viz. Physical mixtures, Kneading method and Solvent evaporation method. The characterizations of prepared solid dispersions were done by Differential Scanning Calorimetry (DSC) and they were also characterized for their drug content and in-vitro dissolution studies Outcome: From DSC studies it was confirmed that the drug was dispersed in the carrier at molecular level in the obtained co-evaporates. From the results of dissolution studies, it was confirmed that the solid dispersions could enhance the bioavailability of Ziprasidone.Ziprasidone structure ________________________________________ Hygeia.

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Section: Kneading Methods 7-13mentioning

confidence: 99%

Section: B) Analytical Methodsmentioning

confidence: 99%

Section: Murthy S N Varanasi Et Al D) Evaluation Of Solid Dispersionsmentioning

confidence: 99%

Section: Murthy S N Varanasi Et Al D) Evaluation Of Solid Dispersionsmentioning

confidence: 99%

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2014

Hygeia.J.D.Med.

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“…The poly(methacrylic acid and methacrylate) copolymer allows release of load at a specific pH within the gastrointestinal tract. Table 6, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147 reveals a few examples of nanoparticulate systems which improve bioavailability.…”

Section: Formulation Approaches For Manipulating Solubility and Permementioning

confidence: 99%

Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles

Shekhawat

Pokharkar

2017

Acta Pharmaceutica Sinica B

130

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Oral drug absorption is a process influenced by the physicochemical and biopharmaceutical properties of the drug and its inter-relationship with the gastrointestinal tract. Drug solubility, dissolution and permeability across intestinal barrier are the key parameters controlling absorption. This review provides an overview of the factors that affect drug absorption and the classification of a drug on the basis of solubility and permeability. The biopharmaceutical classification system (BCS) was introduced in early 90׳s and is a regulatory tool used to predict bioavailability problems associated with a new entity, thereby helping in the development of a drug product. Strategies to combat solubility and permeability issues are also discussed.

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Cyclodextrins in Ocular Drug Delivery

Anand

Braga²

2016

Nano-Biomaterials for Ophthalmic Drug Delivery

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Characterization, dissolution and in vivo evaluation of solid acetazolamide complexes

Cited by 23 publications

References 24 publications

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Understanding peroral absorption: regulatory aspects and contemporary approaches to tackling solubility and permeability hurdles

Cyclodextrins in Ocular Drug Delivery

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