Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus <i>Dichotomopilus funicola</i>
 Y3 from pigeon pea [<i>Cajanus cajan</i>
 (L.) Millsp.]

Gu, Cheng‐Bo; Ma, Haoran; Ning, W.J.; Niu, Lili; Han, Huiying; Yuan, Xinyi; Fu, Yujie

doi:10.1111/jam.13928

Cited by 21 publications

(13 citation statements)

References 42 publications

(76 reference statements)

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“…e isomer pair and their derivatives are ubiquitously available in natural sources such as insects [7], honey [8], fungus Dichotomopilus funicola Y3 [9], and even plant tissues, including Tetrastigma hemsleyanum leaves [10], buckwheat sprouts [11], leaves of Echinodorus scaber [12], and others.…”

Section: Natural Sources and Chemical Structural Properties Ofmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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Background. Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. Aim of the Study. The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020. Results. In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications. Conclusion. Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.

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Section: Natural Sources and Chemical Structural Properties Ofmentioning

confidence: 99%

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Abdulai

Kwofie

Gbewonyo

et al. 2021

The Scientific World Journal

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“…Higher contents of these compounds in moringa leaves could result from the use of other components of the substrate by the moulds during fermentation. However, it is worth mentioning that some fungal strains ( Fusarium solani G6, Dichotomopilus funicola Y3) were reported to produce vitexin [ 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Phenolic Profile, Antioxidant Activity and Amino Acid Composition of Moringa Leaves Fermented with Edible Fungal Strains

Starzyńska-Janiszewska

Stodolak

Fernández-Fernández

et al. 2022

Foods

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Solid-state fermentation (SSF) is widely recognised as a technique to increase the bioactive potential and nutritional value of plant materials. However, the effect of this biotreatment differs for individual substrates. This study aimed to evaluate the impact of SSF with filamentous fungi (Rhizopus, Aspergillus, and Neurospora) on a moringa leaf phenolic profile, antioxidant activity, and amino acid composition. A total of 43 phenolic compounds were determined in the dried leaves analysed by HPLC-ESI-TOF-MS. The leaves contained 11.79 mg/g of free phenolics: flavonols (80.6%, mainly quercetin and kaempferol glycosides), hydroxycinnamic acid derivatives (12.3%), vitexin and vicenin (6.9%), and a small amount of lignan (isolariciresinol isomers). The result of the 1-day fermentation was a slight enhancement in the concentration of individual free phenolics (flavones) and the antioxidant activity of the leaves. However, extending the incubation period caused a significant decrease in those parameters and cannot be recommended for obtaining a food fortificant from moringa leaves. In contrast, the 3-day fermentation with N. intermedia led to a 26% average accumulation of individual amino acids. Therefore, the SSF with Neurospora can be a promising method for improving the nutritional composition of moringa leaves and needs further investigation.

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“…The chemical complexity of microorganisms is relatively lower than that of plants. A less complex chemical profile of endophytes makes the purification process of metabolites easier and potentially less costly [ 3 , 103 , 169 ].…”

Section: Antiages Compounds Production: Endophytes Vs Plantsmentioning

confidence: 99%

“…Flavonoids can be classified into isoflavones, flavones, flavanones, flavonols and anthocyanins. Figure 5 shows some antiAGEs flavonoids reported as metabolites in endophytes consisting of: apigenin and derivatives such as vitexin and isovitexin [78,81,90,[103][104][105], kaempferol and derivatives [91,110,111], luteolin [78,81,113], quercetin and derivatives [81,88,90,91,113], catechin [78], daidzein [118], genistein [90,118], icariin [78] and rutin and derivatives [78,81,91]. Flavonoids are polyphenolic compounds well known for their beneficial effects on health, some of them have shown antiAGEs activity [12,157,158].…”

Section: Plant-derived Antiages Polyphenols Reported In Endophytesmentioning

confidence: 99%

“…Flavonoids can be classified into isoflavones, flavones, flavanones, flavonols and anthocyanins. Figure 5 shows some antiAGEs flavonoids reported as metabolites in endophytes consisting of: apigenin and derivatives such as vitexin and isovitexin [78,81,90,[103][104][105], kaempferol and derivatives [91,110,111], luteolin [78,81,113], quercetin and derivatives [81,88,90,91,113], catechin [78], daidzein [118], genistein [90,118], icariin [78] and rutin and derivatives [78,81,91]. Other antiAGEs phenolic compounds that have been reported in endophytes such as resveratrol, a stilbene [124][125][126][127][128], tyrosol [131][132][133][134], ellagic acid [80,91], and 2,4-diacetylphloroglucinol [68] are shown in Figure 6.…”

Section: Plant-derived Antiages Polyphenols Reported In Endophytesmentioning

confidence: 99%

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Endophytes, a Potential Source of Bioactive Compounds to Curtail the Formation–Accumulation of Advanced Glycation End Products: A Review

Rochín-Hernández

Flores-Cotera

2022

Molecules

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Endophytes, microorganisms that live in the internal tissues and organs of the plants, are known to produce numerous bioactive compounds, including, at times, some phytochemicals of their host plant. For such reason, endophytes have been quoted as a potential source for discovering bioactive compounds, particularly, of medical interest. Currently, many non-communicable diseases are threatening global human health, noticeably: diabetes, neurodegenerative diseases, cancer, and other ailment related to chronic inflammation and ageing. Intriguingly, the pathogenesis and development of these diseases have been linked to an excessive formation and accumulation of advanced glycation end products (AGEs). AGEs are a heterogeneous group of compounds that can alter the conformation, function, and lifetime of proteins. Therefore, compounds that prevent the formation and consequent accumulation of AGEs (AntiAGEs compounds) could be useful to delay the progress of some chronic diseases, and/or harmful effects of undue AGEs accumulation. Despite the remarkable ability of endophytes to produce bioactive compounds, most of the natural antiAGEs compounds reported in the literature are derived from plants. Accordingly, this work covers 26 plant antiAGEs compounds and some derivatives that have been reported as endophytic metabolites, and discusses the importance, possible advantages, and challenges of using endophytes as a potential source of antiAGEs compounds.

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Characterization, culture medium optimization and antioxidant activity of an endophytic vitexin-producing fungus Dichotomopilus funicola Y3 from pigeon pea [Cajanus cajan (L.) Millsp.]

Abstract: These findings provide an alternative source for large-scale production of vitexin by endophytic fungal fermentation and have a promising prospect in food and pharmaceutical industry.

Cited by 21 publications

References 42 publications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Multitargeted Effects of Vitexin and Isovitexin on Diabetes Mellitus and Its Complications

Phenolic Profile, Antioxidant Activity and Amino Acid Composition of Moringa Leaves Fermented with Edible Fungal Strains

Endophytes, a Potential Source of Bioactive Compounds to Curtail the Formation–Accumulation of Advanced Glycation End Products: A Review

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