Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids

Al‐Mohaimeed, Amal M.; Alothman, Asma A.

doi:10.1155/2019/1064942

Cited by 5 publications

(3 citation statements)

References 19 publications

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“…constants were calculated for each mixed ligand system. They were compared to each other to decide which ligand acts as a primary ligand and which one acts as a secondary ligand [22].…”

Section: M+a↔m-a (3) M-a+l↔m-a-l (4) M+a+l↔m-a-l (5)mentioning

confidence: 99%

modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

Abdelhameed

Orabi

Abbas

et al. 2021

Advances in Environmental and Life Sciences

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Antibiotics have saved countless lives and continue to be the backbone for treating bacterial infections. β-Lactam antibiotics have been successfully introduced as antibacterial agents in the early 1950s. They are still the most popular drugs for treating bacterial infections of many diseases. As a result, the biological applications of these compounds and their complexes have attracted remarkable of metal ions (Cu (II), Co (II), Ni (II), Zn (II), Eu (III), and Tb (III) with amoxicillin(H 2 Ax) (Ax) and some selected amino acids (L-glycine (Gly), L-methionine (Met), L-asparagine (Asn), L-histidine (His) and DL-alanine (Ala) have been investigated potentiometrically, 0.1M KNO 3 ionic strength, in an aqueous medium at 20 o C. The dissociation constants and formation constants of ligands and their metal complexes were calculated from potentiometric data using the Irriving-Rossotti method. The acid-base characteristics of ligands have been examined and discussed. It was found that complexes It has been found that amoxicillin does as a primary ligand for the interaction of metal ions in the presence of glycine, alanine, or histidine amino acids. On the other hand, in the case of methionine or asparagine, amoxicillin acts as a secondary ligand. Stabilities of ternary complexes to metal ions were in the following order: Zn(II)< Cu(II) > Ni(II) >Co(II) for transition metal ions and Eu(III) > Tb(III) for lanthanide metal ions. The concentration distribution curves of the binary and ternary complexes formed in the solution were evaluated as a function of pH using the HYSS program.

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“…constants were calculated for each mixed ligand system. They were compared to each other to decide which ligand acts as a primary ligand and which one acts as a secondary ligand [22].…”

Section: M+a↔m-a (3) M-a+l↔m-a-l (4) M+a+l↔m-a-l (5)mentioning

confidence: 99%

modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

Abdelhameed

Orabi

Abbas

et al. 2021

Advances in Environmental and Life Sciences

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“…Hence, the study of metal-amino acid complexes is of immense importance with wide applications in the field of biology, therapeutic use in drug designing and diagnosis of disease in medicinal inorganic chemistry [ 5 ], which offers a better chance to understand the binding affinities involved in metal-protein residues. Thus, researchers have made an extensive study on metal complexes with bioactive ligands [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Speciation study involving mononuclear binary transition metal (CoII, NiII and CuII) complexes of L-methionine in non-ionic micellar medium

Neeraja

Bindu

2021

Heliyon

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The present work aims to evaluate the binding capacities of binary complexes of L-Methionine with transition metal ions Co II , Ni II and Cu II in Triton X 100-water mixtures, a non-ionic micellar media of different compositions (0.0–2.5% (v/v)), investigated under the experimental conditions of 0.16 mol/dm 3 ionic strength using NaNO 3 at a temperature of 303.0 ± 0.1 K Potentiometrically. The potentiometric data was assessed by Irving-Rossotti pH metric technique with the least-squares method of MINIQUAD75, a computer program. The selectivity of the best fit model obtained by continuous exhaustive chemical modelling studies and the accuracy of the results is assessed based on statistical parameters. MLH, ML and ML 2 are the identified species for the three M(Co II , Ni II and Cu II ) - Met systems. The shift in the equilibrium of binary metal-methionine complexes with variation in composition (0.0–2.5%) of the solvent can be explained by electrostatic together with non-electrostatic forces contributed by the interaction of solute with solvent.

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“…4,5 Although DUL is deemed to be one of the main antidepressant drugs, the development of efficient and exact methods for the evaluation of this active compound are of interest. Several analytical methods are implemented in the determination of DUL including potentiometry, [6][7][8] spectrofluorimetry, [9][10][11] spectrophotometry, [12][13][14][15] capillary zone electrophoresis, 16,17 gas chromatography-mass spectrometry, 18 high-performance liquid chromatography, [19][20][21][22][23] liquid chromatography coupled with mass spectrometry, [24][25][26][27][28][29][30][31] high performance thin layer chromatography. 32,33 Although developed methods are applicable with high sensitivity, they are not efficient in the detection of DUL in real time of consumption, requiring sample pretreatment preparations, a longer analysis time and involve the use of expensive apparatuses.…”

mentioning

confidence: 99%

Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation

Lović¹,

Bogdanović²,

Tadić³

et al. 2022

J. Electrochem. Soc.

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Duloxetine hydrochloride (DUL) is effective in treating depression, and was examined for electroanalytical purposes. The DUL standard was investigated by cyclic voltammetry (CV) and determined using differential pulse voltammetry (DPV) via its electro-oxidation at the Au electrode in 0.05 M NaHCO3. DPV showed a linear dependency of the anodic peak currents vs DUL standard concentrations in the range from 0.1 to 3.33 μg ml−1 with the values of the limit of detection (LOD) and the limit of quantification (LOQ): 0.133 and 0.667 μg ml−1, respectively. Using the constructed and validated calibration curve, the values of unknown DUL concentrations in both Taita® tablets and in human serum spiked with the standard were determined. The number of protons and electrons transferred was calculated and possible reaction mechanisms taking place on the surface of both electrodes were proposed. The Au electrode exhibited a better sensitivity and a wider range of current vs concentration linear dependency for DUL quantitative determination than the GC electrode. The study of DUL degradation showed that at the Au and GC electrodes, after 4.5 h of potential cycling, degradation occurs, giving formaldehyde as a product, which was confirmed by high performance liquid chromatography (HPLC).

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Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids

Cited by 5 publications

References 19 publications

modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

modern view for binary and ternary complexes of metal ions with amoxicillin and some amino acids

Speciation study involving mononuclear binary transition metal (CoII, NiII and CuII) complexes of L-methionine in non-ionic micellar medium

Electrochemical Behavior of Duloxetine Hydrochloride at Au and GC Solid Electrodes: Its Quantitative Determination and Degradation

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