Characterization, bioactivity, and antimicrobial activity of CuO-containing devitrite glass–ceramic

Omar, Areg E.; Zayed, Heba S.; Hamzawy, Esmat M. A.

doi:10.1007/s00339-021-05204-2

Cited by 3 publications

(6 citation statements)

References 35 publications

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“…The antibacterial properties of copper(II) oxide have been the focus of several studies, as described by Omar et al . 70 and Acikbas et al 71 , among others. Their results on the microbial activity of CuO correspond well with our results, particularly the evaluation of microbial purity in which no microbial growth was observed in the cement samples with added CuO.…”

Section: Resultsmentioning

confidence: 94%

Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites

Ślosarczyk

Klapiszewska

Parus

et al. 2023

Sci Rep

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CuO nanoparticles (NPs) were added to cement matrices in quantities of 0.25, 0.50 and 1.00 wt% to inhibit the growth of Gram-positive (Bacillus cereus, Staphylococcus aureus) and Gram-negative (Pseudomonas aeruginosa, Escherichia coli) bacteria. It was shown that CuO NPs, in all tested concentrations, improved the antibacterial properties of the cement matrix. Nevertheless, the best mechanical, structural and durability properties were obtained for cement composites doped with CuO NPs at 0.25 wt%. Larger amounts of NPs caused a decrease in all parameters relative to the reference mortar, which may be the result of a slight change in the porosity of the composite microstructure. For 0.50 wt% CuO NPs, a slight increase in the volume of micropores in the cement matrix was observed, and an increased number of larger pores was confirmed by non-invasive computed tomography (CT). The reduction in the mechanical parameters of composites with 0.50 and 1.00 wt% CuO NPs may also be due to the slower hydration of the cement binder, as confirmed by changes in the heat of hydration for these configurations, or agglomeration of NPs, especially for the 1.00 wt% concentration, which was manifested in a decrease in the plasticity of the mortars.

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Section: Resultsmentioning

confidence: 94%

Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites

Ślosarczyk

Klapiszewska

Parus

et al. 2023

Sci Rep

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“…7. Both samples illustrate the creation of an apatite layer as showed by the presence of characteristic bands of hydroxyapatite [40][41][42].…”

Section: Ftir Analysis After Sbf Immersionmentioning

confidence: 95%

Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Ahmed,

Omar,

Zayed

et al. 2024

Appl. Phys. A

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Zn-MOF/bioactive glass nanoparticles were successfully prepared using quick–alkali-modified sol–gel and tested for gentamicin drug delivery. Samples of 0 and 0.8 mol% Zn MOF contents (BG and BG/Zn MOF, respectively) were characterized using XRD, FTIR, TEM, and SEM/EDX. In addition, zeta characteristics and surface area parameters were also evaluated. Moreover, the cell viability of the prepared samples was tested against the osteosarcoma MG-63 cell line to evaluate the ability of prepared samples for bone regeneration. In addition, the antimicrobial activity of glass samples with and without antibiotics was determined against different microorganisms. Finally, the samples were loaded with gentamicin drug, and drug release profile and kinetics were studied too. XRD and FTIR results confirmed the physicochemical properties of the prepared samples. TEM results showed that particles were in the nano-sized range in both samples; however, the presence of Zn MOF increased the dispersity of particles. Both samples were bioactive, as indicated by hydroxyapatite formation on their surfaces. Cytotoxicity estimation of prepared materials exhibited their safe and nontoxic nature. BG/Zn MOF sample demonstrated prolonged drug release and excellent antimicrobial activity in comparison to BG alone. Therefore, the present study provides promising preliminary results regarding the usage of BG/Zn MOF nanoparticles loaded with gentamicin as an effective approach for bone regeneration. Graphical Abstract

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“…For the following formation of the calcium phosphate layer (hydroxyapatite), the latter group will serve as a nucleation site. Additionally, the increased ionic activity of apatite caused by the pH rise with the release of Na + ions would hasten the nucleation of apatite [3].…”

Section: Morphological Analysismentioning

confidence: 99%

“…These defects have no self-healing ability, so reconstructive surgery can offer a treatment by using bioactive materials for the regeneration of bone and mend the defects in the specific circumstances. Any bio-alternative substance should exhibit the following characteristics in addition to cyto-biocompatibility: osteoproduction, osteoconduction, bioactivity, adequate mechanical properties, appropriate degradation rate, and antibacterial impact [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, devitrite phases are major role in 45S5 BGs. Omar et al observed that it can release more ions and speed up the apatite precipitation, which may have stronger bioactivity than later ones [3]. The sintering process plays a crucial role in the synthesis of 45S5 BG, a bioactive material widely used in the various biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Devitrite (Na₂Ca₃Si₆O₁₆) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties

Elakkiya,

Ashok Raja,

Balakumar

2024

Biomed. Mater.

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This research study is primarily centred around calcination temperature and time influence on phase formation in bioactive glasses (BGs). In the present study, bioactive glass with a nominal composition of 45S5 was synthesized through the sol-gel process. The developed BGs then underwent heat treatment for various sintering durations and temperatures. XRD patterns of the BGs reveals that the sintering process led to the crystallization of both devitrite (Na2Ca3Si6O16) and combeite (Na2Ca2Si3O9) phases. The FESEM study divulges morphological alterations, from sheet-like to rod-like structures to eventually transforming into spherical and sheet-like structures. The surface area and Type-IV mesoporous porosity were validated through BET analysis, highlighting a notable increase in pore volume and mechanical strength at a lower sintering temperature. In vitro apatite formation was carried out in Hank’s balance salt in order to evaluate the bioactivity of the glass. After 7 days of immersion in SBF, XRD patterns and SEM micrographs results showed that formation of hydroxyapatite layer on the surface of the BGs. The bioactive glass compatibility with erythrocytes (red blood cells) was also studied, and the results revealed that there was only a low 2% lysis, showing good hemocompatibility. The drug loading and release behaviour of the BGs was studied in the in vitro analysis. The findings showed a high drug encapsulation effectiveness of up to 90% and continuous drug release from the BGs for 24 hours. The materials biocompatibility was unambiguously confirmed by cytocompatibility and proliferation studies. This study provides compelling evidence for the exceptional efficacy and promise of the distinct 45S5 BGs in advancing the field of regenerative medicine.

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Characterization, bioactivity, and antimicrobial activity of CuO-containing devitrite glass–ceramic

Cited by 3 publications

References 35 publications

Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites

Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites

Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Devitrite (Na₂Ca₃Si₆O₁₆) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties

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Characterization, bioactivity, and antimicrobial activity of CuO-containing devitrite glass–ceramic

Cited by 3 publications

References 35 publications

Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites

Antimicrobial action and chemical and physical properties of CuO-doped engineered cementitious composites

Bioactive glass doped with zinc-based metal–organic frameworks (Zn/MOF) nanoparticles for antibiotic delivery applications

Devitrite (Na2Ca3Si6O16) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties

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Devitrite (Na₂Ca₃Si₆O₁₆) phase dominated nanostructured 45S5 bioactive glass: exploring its structural and biological properties