Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Optimally Using Saudi Propolis

Al-Fakeh, Maged S.; Osman, Samir Osman Mohammed; Gassoumi, M.; Rabhi, Mokded; Omer, Mohamed I.

doi:10.3390/nano11102666

Cited by 21 publications

(8 citation statements)

References 55 publications

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“…It has been claimed that palladium NPs can be biosynthesized cost-effectively utilizing Saudi propolis. With an IC 50 of 104.79 µg/mL, palladium NPs successfully cured MCF-7 ductal cancer (Al-Fakeh et al., 2021 ). These palladium NPs have been modified to treat MCF7 breast cancer cells using PVP-functionalized palladium.…”

Section: Metal Nanoparticles Used For Cancer Therapymentioning

confidence: 99%

Metal nanoparticles as a promising technology in targeted cancer treatment

Zhang

Guo

et al. 2022

Drug Delivery

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Traditional anticancer treatments have several limitations, but cancer is still one of the deadliest diseases. As a result, new anticancer drugs are required for the treatment of cancer. The use of metal nanoparticles (NPs) as alternative chemotherapeutic drugs is on the rise in cancer research. Metal NPs have the potential for use in a wide range of applications. Natural or surface-induced anticancer effects can be found in metals. The focus of this review is on the therapeutic potential of metal-based NPs. The potential of various types of metal NPs for tumor targeting will be discussed for cancer treatment. The in vivo application of metal NPs for solid tumors will be reviewed. Risk factors involved in the clinical application of metal NPs will also be summarized.

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Section: Metal Nanoparticles Used For Cancer Therapymentioning

confidence: 99%

Metal nanoparticles as a promising technology in targeted cancer treatment

Zhang

Guo

et al. 2022

Drug Delivery

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“…The diffraction peaks of mordenite are 6.5 , 9. 65 These shifting and changes in diffraction peaks are due to the electrical interaction between cations of Ag nanoparticles and the mordenite framework [36,39,40].…”

Section: Xrd Analysismentioning

confidence: 99%

“…Also, the possibility of a change and modification in the DNA of the bacteria cell wall allows the penetration of silver nanoparticles into this bacterial cell and thus leads to cell death or DNA damage at least, and this is the second possible mechanism. The third mechanism of the interaction of silver nanoparticles is the interaction of Ag+ ions with sulfur-containing proteins in the cell wall, as well as the disruption of the bacterial cell wall and the cell end [19,[60][61][62][63][64][65].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Waterborne pathogens treatment using biosynthesized silver‐mordenite nanocomposites in aqueous propolis extracts: Characterization and antibacterial activity

Mohammed

Al‐Hakimi

2022

Applied Organom Chemis

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This paper deals with the preparation of silver/mordenite nanocomposite using aqueous propolis extract along with different concentrations of silver nitrate. The study of the prepared samples' structural properties gave two possibilities for the nanocomposite formation process, and this was confirmed by the UV-visible absorption spectrum and the energy-dispersive X-ray spectroscopy. Unexpectedly, the decrease in the size of these nanocomposites (14-21 nm) showed a non-linear behavior with increasing silver nitrate concentration because of the presence of propolis during urbanization, and this was explained using the results of the transmission electron microscopy images and X-ray diffraction. The Ag/mordenite nanocomposites showed the effective ability to eliminate the two types of bacteria (Gram-positive [Staphylococcus aureus] and Gram-negative [Escherichia Coli]). As well, these nanocomposites demonstrated with simple experiments the removal efficiency of some dyes pollutants (such as methylene blue, methyl orange, malachite green, indigo, and Congo red) from aqueous solutions. These results were explained in this article.

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“…Several studies about the anti-cancer and antioxidant activities of propolis have been deposited in the literature. İndependent research groups reported the cytotoxic and anti-proliferative in uences of propolis and its NPs on various cancer cell lines [26][27][28][29][30]. However, there is no such study examining synthesis, characterization, and investigation of anticancer and antioxidant activities of AgNPs using Bingöl propolis (PrAgNPs).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells

Dervişoğlu¹,

Darendelioğlu²,

Aykutoğlu³

et al. 2022

Preprint

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Green synthesis of silver nanoparticles (AgNPs) has been reported in several studies. However, no study focused on synthesis, characterization, and investigation of anticancer and antioxidant activities of AgNPs using Bingöl propolis. The morphology and physical properties of PrAgNPs (propolis-AgNPs) were characterized by UV-Vis spectrum of the characteristic silver surface plasmon resonance band, FTIR, XRD, SEM, zeta potential and DLS analysis. XRD and zeta potential analysis revealed a potential of-24.6 mV and formation of cubic crystals, with an average size of 3.45 nm, and a wide band at 420 nm was detected in UV-vis spectroscopy. The in vitro antioxidant capacities of PrAgNPs were evaluated by DPPH radical scavenging, metal chelating, and hydroxyl radical scavenging activities. The cytotoxicity and anticancer activities of ethanolic extract of propolis (EEP) and PrAgNPs were investigated on PC-3 cell lines by WST-1 assay and western blotting. The results demonstrated that PrAgNPs showed higher antioxidant activity than the EEP. The synthesized PrAgNPs were also shown to inhibit PC-3 cell proliferation. In the immunoblotting study, the expression of levels of apoptotic markers pro-caspase-3 and cytochrome c confirmed apoptosis induced by PrAgNPs. The current study reveals that green synthesized PrAgNPs possess antioxidant, anticancer, and apoptotic activities on human prostate cancer cell line PC-3 and pave the way for the possible treatment of the various cancers.

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Characterization, Antimicrobial and Anticancer Properties of Palladium Nanoparticles Biosynthesized Optimally Using Saudi Propolis

Cited by 21 publications

References 55 publications

Metal nanoparticles as a promising technology in targeted cancer treatment

Metal nanoparticles as a promising technology in targeted cancer treatment

Waterborne pathogens treatment using biosynthesized silver‐mordenite nanocomposites in aqueous propolis extracts: Characterization and antibacterial activity

Synthesis of Silver Nanoparticles Reduced by Bingol Propolis and Evaluation of Antioxidant, Cytotoxic and Anticancer Activities in PC-3 Cells

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