Characterization and treatment of transitional cell carcinoma of the abdominal wall in dogs: 24 cases (1985–2010)

Higuchi, Takashi; Burcham, Grant N.; Childress, Michael O.; Rohleder, Jacob J.; Bonney, Patty L.; Ramos‐Vara, José A.; Knapp, Deborah W.

doi:10.2460/javma.242.4.499

Cited by 54 publications

(46 citation statements)

References 16 publications

(27 reference statements)

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“…Needle tract implantation overall is considered rare 23. It has been reported that abdominal wall TCC occurred in 6/367 patients having had ultrasound‐guided fine‐needle aspiration of the prostate gland or urinary bladder 24. This number excluded dogs that had a previous cystotomy performed.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

Budreckis

Byrne

Pollard

et al. 2015

Veterinary Internal Medicne

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BackgroundUrinary tract infections (UTI) are believed to be common in dogs with transitional cell carcinoma (TCC), but incidence and contributing factors have not been reported.ObjectivesTo determine the frequency and bacterial agents associated with UTI in dogs with TCC and define contributing factors.AnimalsEighty‐five dogs with a history of urogenital TCC undergoing treatment with chemotherapy that had at least 1 urine culture performed.MethodsMedical records and culture results were retrospectively reviewed and ultrasound images were reviewed when available. Clinical factors were evaluated statistically for association with positive culture.ResultsFifty‐five percent (47/85) of dogs had at least 1 positive culture during the course of treatment. Female dogs (80%, 40/50) were more likely than male dogs (29%, 10/35) to have at least 1 positive culture. Ultrasound examination determined that female dogs were more likely to have urethral (74%, 31/42) or trigonal tumor involvement (71%, 30/42) compared to male dogs (32%, 9/28 and 43%, 12/28, respectively). The most commonly isolated organisms were Staphylococcus spp. (23.9%, 29/121) and Escherichia coli (19.8%, 24/121). Dogs with urethral involvement of TCC were significantly more likely to have at least 1 positive culture than dogs without urethral involvement (75%, 30/40 versus 30%, 9/30).Conclusions Urinary tract infection is common in dogs with TCC highlighting the importance of regular monitoring for bacterial cystitis in dogs with TCC. In addition, clinical factors such as tumor location and sex may be predictive of positive culture and can help clinicians assess the risk of UTI.

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Section: Discussionmentioning

confidence: 99%

Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

Budreckis

Byrne

Pollard

et al. 2015

Veterinary Internal Medicne

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“…Bladder cancer, also called transitional cell carcinoma (TCC), or urothelial carcinoma (UC) is yet another tumour that affects both humans and their pet dogs [112,113]. In humans, environmental exposure, including tobacco smoke, is a major risk factor for UC.…”

Section: (C) Bladder Cancermentioning

confidence: 99%

Comparative oncology: what dogs and other species can teach us about humans with cancer

Schiffman

Breen

2015

Phil. Trans. R. Soc. B

307

315

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One contribution of 18 to a theme issue 'Cancer across life: Peto's paradox and the promise of comparative oncology'. Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs (approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The interdisciplinary field of comparative oncology offers a unique and strong opportunity to learn more about universal cancer risk and development through epidemiology, genetic and genomic investigations. Working across species, researchers from human and veterinary medicine can combine scientific findings to understand more quickly the origins of cancer and translate these findings to novel therapies to benefit both human and animals. This review begins with the genetic origins of canines and their advantage in cancer research. We next focus on recent findings in comparative oncology related to inherited, or genetic, risk for tumour development. We then detail the somatic, or genomic, changes within tumours and the similarities between species. The shared cancers between humans and dogs that we discuss include sarcoma (osteosarcoma, soft tissue sarcoma, histiocytic sarcoma, hemangiosarcoma), haematological malignancies (lymphoma, leukaemia), bladder cancer, intracranial neoplasms (meningioma, glioma) and melanoma. Tumour risk in other animal species is also briefly discussed. As the field of genomics advances, we predict that comparative oncology will continue to benefit both humans and the animals that live among us.

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“…Thus, studying canine osteosarcoma and the application of new techniques will help reveal the misexpression of other genes involved in human osteosarcoma. Bladder cancer, also known as transitional cell carcinoma (TCC) or urothelial carcinoma (UC) and affects both canines and humans (Higuchi et al, 2013;Park and Hahn, 2014). TCC comprises about 2% of all malignant tumours in dogs (Meuten and Mueten, 2014).…”

Section: Http://wwwopenveterinaryjournalcom F Sultan and Ba Ganaiementioning

confidence: 99%

Comparative oncology: Integrating human and veterinary medicine

Sultan

Ganaie²

2018

Open Vet J.

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Cancer constitutes the major health problem both in human and veterinary medicine. Comparative oncology as an integrative approach offers to learn more about naturally occurring cancers across different species. Canine models have many advantages as they experience spontaneous disease, have many genes similar to human genes, five to seven-fold accelerated ageing compared to humans, respond to treatments similarly as humans do and health care levels second only to humans. Also, the clinical trials in canines could generate more robust data, as their spontaneous nature mimics real-life situations and could be translated to humans.

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Characterization and treatment of transitional cell carcinoma of the abdominal wall in dogs: 24 cases (1985–2010)

Cited by 54 publications

References 16 publications

Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

Bacterial Urinary Tract Infections Associated with Transitional Cell Carcinoma in Dogs

Comparative oncology: what dogs and other species can teach us about humans with cancer

Comparative oncology: Integrating human and veterinary medicine

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