Characterization and treatment of patients with chronic rhinosinusitis and nasal polyps

Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

“…It is widely accepted that eosinophils are a major inflammatory cell in upper (CRS/nasal polyps) and lower airways of patients with NERD . Peripheral eosinophilia is found in more than 50% of patients with NERD and correlated with the severity of CRS . A high peripheral eosinophil count is associated with airflow restriction, severe symptoms, and frequent asthma exacerbations.…”

Peripheral blood eosinophilia correlates with hyperplastic nasal polyp growth

“…Several studies have shown that CRSwNP is closely linked to asthma. The incidence of asthma in patients with CRSwNP has been reported to range from as high as 71% to 94% . Asthma severity is well known to correlate with bronchial tissue and sputum eosinophilia and with PBE levels .…”

“…Chronic rhinosinusitus with nasal polyposis (CRSwNP) is considered one of the more severe types of CRS . Surgical and medical treatment with oral corticosteroids can reduce polyp size . However, neither medical nor surgical approaches can completely control disease progression or recurrence.…”

Symptom-Based Clustering in Chronic Rhinosinusitis Relates to History of Aspirin Sensitivity and Postsurgical Outcomes

“…Baseline descriptive statistical analysis of our patients was performed comparing the H-AS and AT groups. Peripheral eosinophilia has been variably reported in CRS patients to be significantly different in patients with aspirin sensitivity versus those without 16, 17 . We report similar findings, however note that pre-surgical eosinophil counts did not differ between those CRS patients with H-AS or AT group, but there was significant serum eosinophilia in H-AS subjects when the highest recorded eosinophil count was compared between the two groups.…”