Characterization and toxicology evaluation of zirconium oxide nanoparticles on the embryonic development of zebrafish, <i>Danio rerio</i>

Karthiga, Perumal; Ponnanikajamideen, M.; Rajendran, R. Samuel; Annadurai, G.; Rajeshkumar, S.

doi:10.1080/01480545.2018.1523186

Cited by 33 publications

(4 citation statements)

References 41 publications

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“…As shown in Figure a, bare PCN-128 shows significant cytotoxicity at concentrations of 50, 75, and 100 μg/mL and 72 h, followed by a sharp fall in viability at an extremely high concentration of 500 μg/mL. As for the bare PCN-222, we observed a similar trend, where it seemed to be biocompatible at concentrations below 100 μg/mL (Figure b), but the cytotoxic effect was also observed at 500 μg/mL for 72 h. Dose-dependent toxicity has recently been reported for slightly smaller (15–20 nm diameter) zirconia oxide nanoparticles (ZrO 2 NPs) with toxicity evident at much lower concentrations than the Zr–MOFs we examined using a cell line . Similar findings to our own were reported by Wang et al also using a cancer-derived cell line.…”

Section: Introductionsupporting

confidence: 80%

Formulation of Metal–Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility

et al. 2021

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Metal−organic framework nanoparticles (nanoMOFs) have been widely studied in biomedical applications. Although substantial efforts have been devoted to the development of biocompatible approaches, the requirement of tedious synthetic steps, toxic reagents, and limitations on the shelf life of nanoparticles in solution are still significant barriers to their translation to clinical use. In this work, we propose a new postsynthetic modification of nanoMOFs with phosphate-functionalized methoxy polyethylene glycol (mPEG− PO 3 ) groups which, when combined with lyophilization, leads to the formation of redispersible solid materials. This approach can serve as a facile and general formulation method for the storage of bare or drugloaded nanoMOFs. The obtained PEGylated nanoMOFs show stable hydrodynamic diameters, improved colloidal stability, and delayed drug-release kinetics compared to their parent nanoMOFs. Ex situ characterization and computational studies reveal that PEGylation of PCN-222 proceeds in a two-step fashion. Most importantly, the lyophilized, PEGylated nanoMOFs can be completely redispersed in water, avoiding common aggregation issues that have limited the use of MOFs in the biomedical field to the wet forma critical limitation for their translation to clinical use as these materials can now be stored as dried samples. The in vitro performance of the addition of mPEG−PO 3 was confirmed by the improved intracellular stability and delayed drug-release capability, including lower cytotoxicity compared with that of the bare nanoMOFs. Furthermore, z-stack confocal microscopy images reveal the colocalization of bare and PEGylated nanoMOFs. This research highlights a facile PEGylation method with mPEG−PO 3 , providing new insights into the design of promising nanocarriers for drug delivery.

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Section: Introductionsupporting

confidence: 80%

Formulation of Metal–Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility

et al. 2021

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“…Subsequently, all biological functions such as osmoregulation, respiration, and excretion are rapidly affected (Person Le Ruyet et al, 1998). Lastly, it is documented that zirconium (oxide nanoparticles) induces developmental toxicity in zebrafish embryos, including mortality, hatching delay, and malformations (Karthiga et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Billings Reservoir (Brazil): Chemical Studies on Water and Chemical and Morphological Studies on Zebrafish Gills

et al. 2021

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Previous study of this research group revealed that water from the Billings reservoir (Brazil) intended for human use (water supply and seafood) has microbiological contamination and causes lethality and brain and behavioral impairments in zebrafish. The objective of this study was to understand what have induced these impairments in the animal model. Chemical analyses on water samples from Rio Pequeno (RP), Rio Grande (RG), and Bororé (BO) rivers, as well as chemical and morphological analyses on zebrafish gills exposed to those waters were performed. Waters samples from RP, RG, and BO presented high levels of phosphorus. BO water and fish gills exposed to this water presented high levels of nitrogen. RG water caused potassium contamination in gills. Phosphorus, nitrogen, and potassium are indicators of anthropogenic pollution. RG water and fish gills exposed to this water presented low levels of calcium, which might be an indication of chemical imbalance that could lead to health problems in aquatic animals. RG and BO waters resulted in zirconium contamination in gills. BO water induced respiratory lamellae thickening in the gills, which may be the underlying mechanism for the observed hypoxia. In conclusion, behavioral, brain, and respiratory defects observed previously were induced by chemical and morphologicalb disturbances due to anthropogenic pollution in the Billings reservoir.

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“…Malformations were described and captured among the embryos and larvae from both the control and treated groups. The photographs of malformed embryos were taken under a stereomicroscope (Optica, Italy Model; T3 15 A, Italy), and the percentage of abnormal embryos was counted for every 24 hours [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential

Rajeshkumar

Santhoshkumar

Jule

et al. 2021

Bioinorganic Chemistry and Applications

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Phytosynthesis particles are the efficient activity of biomedical and environmental. In this present study, the green synthesis of titanium dioxide (TiO2) nanoparticles using the king of bitter herbal plant Andrographis paniculata was synthesized and characterized using XRD, SEM, HRTEM, AFM, and antimicrobial, antioxidant, and antidiabetic activities. The size of the particles HRTEM shows 50 nm, and SEM shows the spherical shape, which reveals the synthesis of TiO2 nanoparticles. XRD spectrum shows crystallinity of nanoparticles, and an average size is calculated about 22.97 nm. The phytosynthesis TiO2 shows the antioxidant and antidiabetic activities. Similarly, toxicity studies have demonstrated the hatching and viability LD 50 value of TiO2 250 μg/L. The current study’s findings suggested that phytosynthesis TiO2 using extract of Andrographis paniculata exposure to potential hazard factors to biomedical and environmental uses.

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Characterization and toxicology evaluation of zirconium oxide nanoparticles on the embryonic development of zebrafish, Danio rerio

Cited by 33 publications

References 41 publications

Formulation of Metal–Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility

Formulation of Metal–Organic Framework-Based Drug Carriers by Controlled Coordination of Methoxy PEG Phosphate: Boosting Colloidal Stability and Redispersibility

Billings Reservoir (Brazil): Chemical Studies on Water and Chemical and Morphological Studies on Zebrafish Gills

Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential

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