Characterization and tissue-specific expression of the rat basic fibroblast growth factor antisense mRNA and protein

Knee, Rai; Li, Audrey W.; Murphy, Paul R.

doi:10.1073/pnas.94.10.4943

Cited by 50 publications

(31 citation statements)

References 44 publications

(46 reference statements)

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“…An antisense transcript regulates its expression (Nudt6), functioning as a repressor (Knee et al, 1997; MacFarlane et al, 2010; MacFarlane and Murphy, 2010). There are also various transcription factors that can bind its promoter elements, such as HoxA10, AP-1 and SP-1 (Shah et al, 2012; Shibata et al, 1991).…”

Section: Molecular Components Of the Fgf Familymentioning

confidence: 99%

“…Here, a decrease in FGFR1 expression was also accompanied by a decrease in glial proliferation in the prefrontal cortex, and the latter effect could be prevented by treatment with FGF2. In keeping with the idea of a mechanism for these effects (other than downstream signaling), FGF2 has an antisense transcript (FGF2-AS) that is known to regulate the expression of FGF2 (Knee et al, 1997; MacFarlane et al, 2010; MacFarlane and Murphy, 2010). Furthermore, corticosterone administration can differentially regulate FGF2 and FGF2-AS expression in both escapable and inescapable shock paradigms (Frank et al, 2007).…”

Section: Affective Functions Of the Fgf Systemmentioning

confidence: 99%

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The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior

Turner

Watson

Akil

2012

Neuron

138

126

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In this review we propose a broader view of the role of the fibroblast growth factor (FGF) family in modulating brain function. We suggest that some of the FGF ligands together with the FGF receptors are altered in individuals with affective disorder and modulate emotionality in animal models. Thus, we propose that members of the FGF family may be genetic predisposing factors for anxiety, depression or substance abuse; that they play a key organizing role during early development but continue to play a central role in neuroplasticity in adulthood; and that they work not only over extended time frames, but also via rapid signaling mechanisms, allowing them to exert an “on-line” influence on behavior. Therefore, the FGF family appears to be a prototype of “switch genes” that are endowed with organizational and modulatory properties across the lifespan, and that may represent molecular candidates as biomarkers and treatment targets for affective and addictive disorders.

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Section: Molecular Components Of the Fgf Familymentioning

confidence: 99%

Section: Affective Functions Of the Fgf Systemmentioning

confidence: 99%

The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior

Turner

Watson

Akil

2012

Neuron

138

126

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“…The following are known mammal cDNA sequences reported to accompany antisense transcripts selected from the recent literature and used in this study: Fgf2 (Knee et al 1997), Hif1a (Thrash-Bingham and Tartof 1999), Tgfb2 (Coker et al 1998), Tnfrsf17 (Hatzoglou et al 2002), Mkrn2 (Gray et al 2001), Hfe (Thenie et al 2001), Klhl1 (Benzow and Koob 2002), Ucn (Shi et al 2000), Wt1 (Moorwood et al 1998), Tnni1 (Podlowski et al 2002), Thra (Hastings et al 2000), Hsp70.2 (Murashov and Wolgemuth 1996), Hoxd-3 (Bedford et al 1995), Tyms (Dolnick 1993), CD3z (Lerner et al 1993), N-myc (Krystal et al 1990), Trp53 (Khochbin and Lawrence 1989), Ercc1 (van Duin et al 1989), and Hoxa11 (Hsieh- Li et al 1995). To identify the known sense-antisense transcripts in the bidirectional transcription pairs calculated in this article, we looked up the GenBank# or Refseq# of the known transcripts in the redundant version of our pair list.…”

Section: A List Of Known Sense Transcripts With Antisense Transcriptsmentioning

confidence: 99%

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

Kiyosawa¹,

Yamanaka²,

Osato³

et al. 2003

Genome Res.

235

199

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We have used the FANTOM2 mouse cDNA set (60,770 clones), public mRNA data, and mouse genome sequence data to identify 2481 pairs of sense-antisense transcripts and 899 further pairs of nonantisense bidirectional transcription based upon genomic mapping. The analysis greatly expands the number of known examples of sense-antisense transcript and nonantisense bidirectional transcription pairs in mammals. The FANTOM2 cDNA set appears to contain substantially large numbers of noncoding transcripts suitable for antisense transcript analysis. The average proportion of loci encoding sense-antisense transcript and nonantisense bidirectional transcription pairs on autosomes was 15.1 and 5.4%, respectively. Those on the X chromosome were 6.3 and 4.2%, respectively. Sense-antisense transcript pairs, rather than nonantisense bidirectional transcription pairs, may be less prevalent on the X chromosome, possibly due to X chromosome inactivation. Sense and antisense transcripts tended to be isolated from the same libraries, where nonantisense bidirectional transcription pairs were not apparently coregulated. The existence of large numbers of natural antisense transcripts implies that the regulation of gene expression by antisense transcripts is more common that previously recognized. The viewer showing mapping patterns of sense-antisense transcript pairs and nonantisense bidirectional transcription pairs on the genome and other related statistical data is available on our Web site.

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“…Nudt6 is synthesized from the complementary strand of Fgf2, and was implicated to function in post-transcriptional regulation of Fgf2 [24]. Studies on Nudt6 are very limited, and its roles are still unknown [25]. This study demonstrates the expression of Nudt6 during brain development for the first time, and its relatively high expression implies that it might have various crucial roles during CNS development (Table 2).…”

Section: Resultsmentioning

confidence: 83%

Temporal expression analysis of angiogenesis-related genes in brain development

et al. 2012

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BackgroundThe current knowledge on molecular pathogenesis of cerebral vascular malformations (CVM), which are believed to arise during development, is very limited. To unravel the molecular mechanisms involved in CVMs, a detailed understanding of the brain vascular development at molecular level is crucial. In this study, we aimed to explore the temporal and comparative expression profile of angiogenesis-related genes in the establishment of brain vasculature.MethodsExpression of a total of 113 angiogenesis-related genes during murine brain development has been analyzed using low-density array systems designed for angiogenesis-related genes. Bai1 (brain specific angiogenesis inhibitor-1), a recently identified novel anti-angiogenic gene, has been selected for further characterization.ResultsWe found that 62 out of 113 analyzed genes have expression in brain development at varying levels. Nineteen of these were differentially expressed between embryonic and postnatal stages (>1.5 fold). Bai1 is strongly expressed on growing blood vessels of cerebral cortex and hippocampus, partially expressed in the lateral regions of striatum, but mostly absent on the thalamus.ConclusionBy showing the comparative expression analysis of angiogenesis-related genes throughout brain development, the data presented here will be a crucial addition to further functional studies on cerebrovascular research.

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Characterization and tissue-specific expression of the rat basic fibroblast growth factor antisense mRNA and protein

Abstract: An RNA transcribed from the antisense strand of the FGF-2 gene has been implicated in the regulation of FGF-2 mRNA stability in amphibian oocytes. We have now cloned and characterized a novel 1.1-kb mRNA (fgf-as) from neonatal rat liver.

Cited by 50 publications

References 44 publications

The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior

The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior

Antisense Transcripts With FANTOM2 Clone Set and Their Implications for Gene Regulation

Temporal expression analysis of angiogenesis-related genes in brain development

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