Characterization and structural analysis of zinc-substituted hydroxyapatites

Characterization, Dissolution, and Solubility of Zn-Substituted Hydroxylapatites [(ZnxCa1−x)5(PO4)3OH] at 25°C

“…The cell parameter decreased with the increasing Zn from 0.00 to 0.08, increased with the increasing Zn from 0.08 to 0.12, and then decreased with the increasing Zn from 0.12 to 0.16 ( Figure 2), which had also been confirmed by some previous researchers [8,10,25]. The cell parameter decreased up to Zn = 0.05 and began to increase over Zn = 0.05 [25].…”

“…The continuous Zn-Ca-HA solid solution could be formed within limited Zn [8,10,25]. The solids prepared can be examined for their compositional homogeneity by considering the broadening of the powder XRD peaks of the major reflections [26].…”

“…The substitution of trace ions in hydroxylapatite can affect not only its lattice parameters and , crystallinity, and morphology, but also its dissolution mechanism and other physicochemical properties [10][11][12]. Zinc is one of the most important essential trace elements for the growth of humans and its incorporation in Ca-hydroxylapatite can significantly improve the bioactivity of Ca-hydroxylapatite [8][9][10]. The slow release of zinc substituted in an implant Ca-hydroxylapatite material can also promote bone metabolism and growth around the implant.…”

“…As the main inorganic constituent of bone and dental enamel of vertebrates, calcium hydroxylapatite (HA) has been broadly used in osteoinductive coatings, bone replacement and repair, dental orthopaedics, and so forth [3,6,[8][9][10][11]. The substitution of trace ions in hydroxylapatite can affect not only its lattice parameters and , crystallinity, and morphology, but also its dissolution mechanism and other physicochemical properties [10][11][12].…”

Structural Analysis and Characterization of Cu, Sr-doped Hydroxyapatite Whiskers

“…Mg 2+ doping has been confirmed to be able to regulate the formation and remodeling of bone tissue; Ren et al, reported that when the molar fraction of Zn in artificial bone was in the range of 5-20%, Zn substitution in the apatite lattice, rather than adsorption on the surfaces, and it had a direct stimulation on the growth of osteogenesis cells, while relatively inhibit the growth of osteoclast [9,10]. Comparing with pure HA, Li et al, found that 5-50 mol% Sr-doped HA had better biocompatibility and biological activity; Kim et al found that ceramics based on HA made in a wet chemical process with addition of Cu(NO 3 ) 2 ·3H 2 O had good antimicrobial [11,12].…”