Characterization and Role of Sterols in Saccharomyces cerevisiae during White Wine Alcoholic Fermentation

Piva, Giovana Girardi; Casalta, Erick; Legras, Jean Luc; Tesnière, Catherine; Sablayrolles, Jean‐Marie; Ferreira, David; Ortiz‐Julien, Anne; Galeote, Virginie; Mouret, Jean-Roch

doi:10.3390/fermentation8020090

Cited by 17 publications

(7 citation statements)

References 177 publications

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“…Cholesterol is the main sterol produced by mammals, while ergosterol is synthetized by fungi, and β-sitosterol or campesterol by plants [ 16 ]. Fungal sterols’ biosynthesis (i.e., ergosterol) involves several enzymes and squalene oxide as an intermediate in the isoprenoid pathway, which is analogous to mammal cholesterol biosynthesis via the acetate-mevalonate route [ 17 ].…”

Section: Prevalence and Current Impact Of Obesity And Dyslipidemiamentioning

confidence: 99%

Novel Lipids to Regulate Obesity and Brain Function: Comparing Available Evidence and Insights from QSAR In Silico Models

Teixeira

Costa

Soares

et al. 2023

Foods

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Lipid molecules, such as policosanol, ergosterol, sphingomyelin, omega 3 rich phosphatidylcholine, α-tocopherol, and sodium butyrate, have emerged as novel additions to the portfolio of bioactive lipids. In this state-of-the-art review, we discuss these lipids, and their activity against obesity and mental or neurological disorders, with a focus on their proposed cellular targets and the ways in which they produce their beneficial effects. Furthermore, this available information is compared with that provided by in silico Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) models in order to understand the usefulness of these tools for the discovery of new bioactive compounds. Accordingly, it was possible to highlight how these lipids interact with various cellular targets related to the molecule transportation and absorption (e.g., α-tocopherol transfer protein for α-Tocopherol, ATP-binding cassette ABC transporters or Apolipoprotein E for sphingomyelins and phospholipids) or other processes, such as the regulation of gene expression (involving Sterol Regulatory Element-Binding Proteins for ergosterol or Peroxisome Proliferator-Activated Receptors in the case of policosanol) and inflammation (the regulation of interleukins by sodium butyrate). When comparing the literature with in silico Quantitative Structure–Activity Relationship (QSAR) models, it was observed that although they are useful for selecting bioactive molecules when compared in batch, the information they provide does not coincide when assessed individually. Our review highlights the importance of considering a broad range of lipids as potential bioactives and the need for accurate prediction of ADMET parameters in the discovery of new biomolecules. The information presented here provides a useful resource for researchers interested in developing new strategies for the treatment of obesity and mental or neurological disorders.

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Section: Prevalence and Current Impact Of Obesity And Dyslipidemiamentioning

confidence: 99%

Novel Lipids to Regulate Obesity and Brain Function: Comparing Available Evidence and Insights from QSAR In Silico Models

Teixeira

Costa

Soares

et al. 2023

Foods

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“…At the same time, sterols are a component of the yeast cell. They are responsible for maintaining the structure of the plasma membrane and essential for yeast development [63].…”

Section: Fractional Composition Of Lipidsmentioning

confidence: 99%

Physico-Chemical and Microbiological Profile of Wine Lees of Red Wines from Local Grapes Varieties

Chioru,

Chiselita,

Suhodol

et al. 2023

FNS

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In the Republic of Moldova, the viticulture industry is a sector with a high economic impact, and the utilization of secondary products from winemaking represents a growing concern regarding environmental sustainability. Wine lees, one of the types of wine waste, is less studied in order to valorize it. Currently it is used in the production of ethyl alcohol, as aggregates in the soil and others. The aim of this study was to characterize from a physico-chemical and microbiological point of view the lees sediments obtained after the primary fermentation of three types of individualized red wines made from autochthonous grapes varieties. It was found that residual yeasts represent a valuable raw material containing carbohydrates (from 14.35% ± 0.19% to 25.11% ± 1.51% SU), lipids (from 4.61% ± 0.21% to 9.41% ± 2.04% SU), proteins (from 42.62% ± 1.57% to 77.62% ± 9.14% SU), anthocyanins (from 9.18 ± 0.15 to 22.78 ± 1.60 mg cianid) and beta-glucans (from 12.84% ± 0.01% to 17.42% ± 0.02%). The pH value of wine lees ranges from 3.49 ± 0.0 to 3.083 ± 0.01, the dry matter from 9.62% ± 0.22% to 25.06% ± 0.42% and the ash from 0.03% ± 0.42% to 0.035% ± 0.21%. The microbiological study confirmed the presence of live yeasts of the genus Saccharomyces cerevisiae, which remain active due to the presence of residual sugars and oxygen. The results of the research are promising and encourage the obtaining of new products with special purpose and added value.

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“…This conversion can be divided into two steps: glycolysis, which breaks down glucose into pyruvates, and fermentation under anaerobic conditions that changes pyruvate into alcohol (Kang & Lee, 2015). While the protein serves as a nitrogen source after biodegradation (Uçkun Kiran, 2014), lipids play an important role in adaptation to fermentation stress (Girardi Piva et al, 2022). Therefore, this proves that a food waste selection step is needed prior to entering any of the bioethanol production steps.…”

Section: Food Waste Selectionmentioning

confidence: 99%

A Review on Bioethanol Production through the Valorization of Food Waste in Indonesia

Trisna¹,

Jai²,

Shirleen³

et al. 2022

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Biofuels are one of the numerous alternatives that are currently being considered to replace fossil fuels as it is more environmentally friendly. Specifically, bioethanol is often thought as a better alternative to gasoline fuel as it is considered cleaner, more renewable, and greener as it is synthesized from renewable feedstock which contributes to the reduction of greenhouse gas emissions to the environment. As bioethanol is produced from carbohydrate and starch rich food crops, food waste (FW) poses a potential source for bioethanol production as it is especially rich in carbohydrates and lipids. Bioethanol production itself consists of several steps which includes food waste selection, pretreatment, saccharification and fermentation, and recovery. Cafeteria FW was reviewed to be the best type of FW for bioethanol production as it has the highest carbohydrate and starch content. Subsequently, acid pretreatment was considered to be the best method due to low cost, high yielding, and time efficient method. Moreover, the non-isothermal simultaneous saccharification and fermentation (NSSF) produces 1.42 g ethanol/L.h with a time of 38 hours. Lastly, the enzyme-assisted extraction technique is most preferred to recover the bioactive compounds as it led to the highest yield of product (94%) compared to other methods.

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Characterization and Role of Sterols in Saccharomyces cerevisiae during White Wine Alcoholic Fermentation

Cited by 17 publications

References 177 publications

Novel Lipids to Regulate Obesity and Brain Function: Comparing Available Evidence and Insights from QSAR In Silico Models

Novel Lipids to Regulate Obesity and Brain Function: Comparing Available Evidence and Insights from QSAR In Silico Models

Physico-Chemical and Microbiological Profile of Wine Lees of Red Wines from Local Grapes Varieties

A Review on Bioethanol Production through the Valorization of Food Waste in Indonesia

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