Abstract:A previously undetected subviral particle, designated the 55S particle because of its position in sucrose density gradients, has been found in cytoplasmic extracts of poliovirus-infected cells. It contains no RNA, is composed of equimolar amounts of the structural polypeptides PlAB, P1C, and P1D, and is stable in vitro under a variety of conditions: presence or absence of EDTA, dilution in low-or high-ionic-strength buffers, suspension-in buffers up to pH 10, incubation at 37°C, and centrifugation to equilibri… Show more
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