Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres

Choi, Joo Hee; Lee, Benel; Jeong, Dae‐Yong; Park, Kyeong Hui; Choi, Eunji; Jeon, Yong-Joon; Dindulkar, Someshwar D.; Cho, Eunae; Hee, Sun; Lee, Kyung-Ho; Lee, Im Soon; Park, Sung Yong; Jun, Bong‐Hyun; Yu, Jae‐Hyuk; Jung, Seunho

doi:10.1016/j.jiec.2016.12.026

Cited by 27 publications

(6 citation statements)

References 60 publications

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“…It could be made into thin films or coatings to keep fruits and vegetables fresh and prolong the storage period 31–34 . Moreover, it could be applied in preparing microcapsules, microspheres, hydrogels, and other drug delivery carriers 35–37 . Owing to the strong hydrophilicity of pullulan because it contains large quantities of hydroxyl groups, zein/pullulan complex particles (ZPPs) can be used as a substitute for synthetic particles with a very small amount of pullulan.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Liu

Shan

et al. 2020

J Sci Food Agric

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BACKGROUND Zein particles are unsuitable as stabilizers of Pickering emulsions because of their high hydrophobicity. However, few studies have reported on the use of a strong hydrophilic neutral polysaccharide to regulate its wettability. In this work, zein/pullulan complex particles (ZPPs) were formulated by an anti‐solvent method to fabricate Pickering emulsions. RESULTS The presence of pullulan increased the size, decreased the zeta, and provided excellent resistance to the gravitational separation of zein. Scanning electron microscopy (SEM) revealed that the shape of zein particles changed from spherical as they became aggregated ZPP nanoparticles. Fourier transform infrared (FTIR) spectroscopy indicated that the flocculation phenomenon of ZPPs was related to the hydrogen bond between zein and pullulan. Moreover, the hydrophobicity of zein was modified by hydrophilic pullulan to endow the ZPPs with nearly neutral wettability when the mass ratio was 15:1, allowing for the preparation of stable Pickering emulsions. In contrast to zein, the ZPPs contributed to building a compact interface layer around the droplets and smaller emulsion droplets. Under a certain ZPP concentration, the size and viscosity of emulsion increased with an increase in the oil volume fraction, indicating that the Pickering emulsions stabilized by ZPPs showed better stability against coalescence. Confocal laser scanning microscopy (CLSM) revealed that the ZPPs constructed a dense filling layer on the surface of oil droplets, thus further emphasizing that ZPPs can potentially be used in fabricating Pickering emulsion gels. CONCLUSION Zein/pullulan complex particles are an excellent Pickering emulsion gel stabilizer that can be used in the delivery system of bioactive substances in food formulations. © 2020 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Liu

Shan

et al. 2020

J Sci Food Agric

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“…In a similar approach, hydroxypropyl cyclosophoraose-PUL (HPCys-Pul) microspheres were formulated using the emulsion-crosslinking method. The microspheres exhibited efficient encapsulation of naproxen and maintenance of drug level in plasma after oral administration was longer (Choi et al, 2017).…”

Section: Pullulan (Pul)mentioning

confidence: 99%

Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications

Hamidi

Okoro

Milan

et al. 2022

Carbohydrate Polymers

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“…Mono-6-deoxy-6-aminoethylamino-β-cyclodextrin (AEA-β-CD) was prepared using a previously detailed method [18].…”

Section: Synthesis Of Mono-6-deoxy-6-aminoethylamino-β-cyclodextrin (mentioning

confidence: 99%

Utilization of Water-Soluble Aminoethylamino–β–Cyclodextrin in the Pfitzinger Reaction—Catalyzed to the Synthesis of Diversely Functionalized Quinaldine

et al. 2020

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In this study we describe the use of an aminoethylamino-β-cyclodextrin (AEA-β-CD) as a supramolecular homogeneous catalyst for the synthesis of a series of diversely substituted quinaldine derivatives which are medicinally important, via Pfitzinger reaction. This supramolecular catalyst exhibited remarkable catalytic activity with high substrate scope to achieve the synthetic targets in good to excellent yield, 69-92%. The structural and morphological properties of the synthesized AEA-β-CD were determined through MALDI-TOF mass spectrometry, NMR, FT-IR, and SEM analysis. Possible reaction mechanisms were determined through molecular host-guest complexation and proposed based on 2D NMR (ROESY) spectroscopy, FT-IR, FE-SEM, and DSC.Polymers 2020, 12, 393 2 of 12 Supramolecular chemistry denotes the chemistry beyond the molecule involving noncovalent intermolecular forces and has a profound influence on the catalysis of a variety of organic reactions to attain higher selectivity mimicking biological phenomena. A major application of supramolecular chemistry is the design and understanding of catalysts and catalysis. Noncovalent interactions are extremely important in catalysis, binding reactants into conformations suitable for reaction and lowering the transition state energy of reaction. Among the various known supramolecular catalysts, β-cyclodextrin (β-CD) is most preferable due to its unique properties, and for economic reasons when compared with αand γ-cyclodextrins. Due to the hydrophobic cavity of β-CD, it allows "host-guest" inclusion complex formation with a wide variety of guest molecules through hydrophobic interaction, and the hydrophilic surface of β-CD makes the complex water-soluble. Modified β-CD provides novel derivatives with unique structures and functions to support the development of different research fields [12]. Additionally, amino-functionalized β-CD has been used as a catalyst in organic synthesis due to its powerful catalytic activity such as in multicomponent reaction (MCR) condensation, oxidation, and asymmetric synthesis [13][14][15].As part of our continuing interest in modified β-CD catalyzed organic synthesis [16,17], herein we report an efficient and eco-friendly procedure for the synthesis of quinaldine derivatives from isatin, 1,3-dicarbonyl, and alcohol in water via Pfitzinger reaction catalyzed by AEA-β-CD, a reusable homogeneous catalyst, at 60 • C (Scheme 1). To the best of our knowledge, the synthesis of diversely functionalized quinaldine, catalyzed by AEA-β-CD, has not been reported yet.

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Characterization and regulated naproxen release of hydroxypropyl cyclosophoraose-pullulan microspheres

Cited by 27 publications

References 60 publications

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Fabrication and characterization of Pickering emulsion gels stabilized by zein/pullulan complex colloidal particles

Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications

Utilization of Water-Soluble Aminoethylamino–β–Cyclodextrin in the Pfitzinger Reaction—Catalyzed to the Synthesis of Diversely Functionalized Quinaldine

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