Characterization and quantification of proliferating cell patterns in endocapillary proliferation

Wu, Qiong; Tanaka, Hisae; Hirukawa, Takashi; Endoh, Masayuki; Fukagawa, Masafumi

doi:10.1093/ndt/gfr797

Cited by 19 publications

(14 citation statements)

References 18 publications

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“…When analyses were restricted to histological covariates, E and T scores were predictive of both time to ESRD and rapid decline in renal function. This is in keeping with data from previous studies of IgAN and other renal diseases, where interstitial fibrosis and glomerulosclerosis are associated with permanent loss of renal function, and reflect the stage of disease at the time of diagnosis, whereas endocapillary hypercellularity is a marker of active inflammation [26][27][28][29][30].…”

Section: Discussionsupporting

confidence: 89%

Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression

et al. 2015

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In a cohort of IgAN patients receiving no immunosuppression, endocapillary proliferation and tubular atrophy/interstitial fibrosis are independent predictors of rate of loss of renal function. The lack of predictive value of E score in other clinicopathological studies is most likely a result of immunosuppression-associated bias. Our findings provide evidence to support immunosuppressive treatment of endocapillary-pattern IgAN.

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Section: Discussionsupporting

confidence: 89%

Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression

et al. 2015

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“…The extent of leukocyte exudation, based on the staining of CD-15, a marker of polymorphonuclear cells, has been shown to be associated with the pattern of endocapillary proliferation in various types of glomerulonephritis [23]. However, it is unknown whether this association also exists in DPLN, as LN was not included for evaluation in this study [23]. The discrepancy in the degree of leukocyte exudation between IV-G and IV-S has to be confirmed in a larger cohort and its significance determined.…”

Section: Discussionmentioning

confidence: 99%

Long-term renal outcomes of childhood-onset global and segmental diffuse proliferative lupus nephritis

Rianthavorn

Buddhasri

2015

Pediatr Nephrol

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“…In IgA nephro pathy, as in other proliferative glomerulonephritides, many of the glomerular cells are leukocytes. 32 The presence of glomerular macro phages correlates with endocapillary hypercellularity and sclerosis, 33 and loss of renal func tion. 34 Whether or not the identification of these cells using immunohisto chemistry might assist pathologists in categorizing lesions, and whether quantifying the number of infiltrating cells is of value as an independent prognostic marker, is currently unknown.…”

Section: Endocapillary Hypercellularitymentioning

confidence: 99%

Pathology of IgA nephropathy

2014

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IgA nephropathy is defined by the presence of IgA-dominant or co-dominant immune deposits within glomeruli. Biopsy specimens meeting these diagnostic criteria have a range of histological changes that are reflected in the variable clinical course of IgA nephropathy. The impact of histology on outcomes in IgA nephropathy has been clarified in a number of large retrospective clinicopathological studies. These studies have consistently demonstrated that the stage of disease at presentation, as indicated by the extent of interstitial fibrosis and tubular atrophy in the biopsy, is the strongest histological predictor of renal survival. The effect of active proliferative lesions on the disease course is less clear cut, owing in part to considerable treatment bias in most published retrospective studies. There is evidence that endocapillary hypercellularity and cellular crescents are responsive to immunosuppressive therapy, but this observation requires confirmation in prospective randomized controlled trials. Future challenges include improving the reproducibility of histological scoring, particularly for the presence and extent of endocapillary lesions, and to improve prognostic modelling by combining histological data with clinical variables and biomarker data.

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Characterization and quantification of proliferating cell patterns in endocapillary proliferation

Cited by 19 publications

References 18 publications

Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression

Prognostic value of endocapillary hypercellularity in IgA nephropathy patients with no immunosuppression

Long-term renal outcomes of childhood-onset global and segmental diffuse proliferative lupus nephritis

Pathology of IgA nephropathy

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