Characterization and Prognostic Value of Persistent Hyponatremia in Patients With Severe Heart Failure in the ESCAPE Trial

Gheorghiade, Mihai; Rossi, Joseph S.; Cotts, William; Shin, David; Hellkamp, Anne S.; Piña, Ileana L.; Fonarow, Gregg C.; DeMarco, Teresa; Pauly, Daniel F.; Rogers, Joseph G.; DiSalvo, Thomas G.; Butler, Javed; Hare, Joshua M.; Francis, Gary S.; Stough, Wendy Gattis; O’Connor, Christopher M.

doi:10.1001/archinte.167.18.1998

Cited by 312 publications

(283 citation statements)

References 25 publications

Supporting

Mentioning

255

Contrasting

Unclassified

Order By: Relevance

“…This percentage was slightly lower than frequencies reported in other studies, which ranged between 20% to 25% [1,12,13] possibly because we did not include the patients who died during hospitalization. Low serum sodium was associated with more clinical complications during admission such as acute confusional status, worsening of renal function, need for vasoactive and hypotensive drugs, and with a higher length of stay, similar to previous studies [1], but also with more urinary infections.…”

Section: Discussioncontrasting

confidence: 56%

Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart failure

Arévalo-Lorido¹,

Gómez²,

Formiga³

et al. 2013

Cardiol J

View full text Add to dashboard Cite

Background: Our aim was to determine if hyponatremia, defined as serum sodium level < 135 mmol/L, is a predictor of worse outcome in a cohort of real-world patients with heart failure (HF (OR 1.08, p < 0.01). Also mortality and readmissions were more frequent in patients with hyponatremia (20.69% and 22.41%, respectively) but after Cox regression adjustment hyponatremia in our cohort was not associated with increase in 90-day all-cause mortality and readmissions, and only CCI remained significant for primary end-point (HR 1.08, p < 0.001). Conclusions: Hyponatremia is an independent predictor of complications during hospitalization in our real-world cohort, but was not associated with 90 days mortality or readmissions. Global comorbidity, however, played an important role, and could influence the mortality and readmissions of our patients. (Cardiol J 2013; 20, 5: 506-512)

show abstract

Section: Discussioncontrasting

confidence: 56%

Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart failure

Arévalo-Lorido¹,

Gómez²,

Formiga³

et al. 2013

Cardiol J

View full text Add to dashboard Cite

show abstract

“…Considering the well-known difficulty in controlling hyponatremia with usual treatment, it is noteworthy the observation of normalization of serum sodium observed in this study 30,31 . The mechanism of correction appears to be independent from the level of vasopressin stimuli, considering that the vasopressin serum level remained elevated and remains to be evaluated in other experiments.…”

Section: Bnp (Pg/ml)supporting

confidence: 54%

Transplante de células da medula óssea na insuficiência cardíaca chagásica: relato da primeira experiência humana

Vilas-Boas¹,

Feitosa²,

Soares³

et al. 2011

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

show abstract

“…6 A recent study reported that when hyponatremia was defined with a less stringent threshold of <138 mEq/L, the incidence at admission rose to 38%. 3 Hyponatremia is a comorbid condition of multiple diseases, occurring in approximately 20% of patients with heart failure, 7,8 and 40% to 57% of patients with advanced cirrhosis. 9,10 The syndrome of the inappropriate release of antidiuretic hormone (SIADH) is additionally a predominant cause of hyponatremia, with a prevalence reported as high as 35% in hospitalized patients.…”

Section: Discussionmentioning

confidence: 99%

“…25 Readmission rates of HN patients in comparison to non-HN patients have been reported in 3 other studies, all of which were conducted on clinical trial patients with heart failure. 7,8,26 Two of these studies, which evaluated only patients with acute class IV heart failure, 8,26 reported that hyponatremia was associated with a significant increase in readmission rates (up to 20% higher), and the other, which evaluated any patients hospitalized for heart failure, did not. 7 The differences there may be partially attributed to the differences in heart failure severity among patient populations, as hyponatremia is an independent predictor of worsening heart failure.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of incremental healthcare resource burden and readmission rates associated with hospitalized hyponatremic patients in the US

Amin

Deitelzweig

Christian

et al. 2012

Journal of Hospital Medicine

View full text Add to dashboard Cite

BACKGROUND:Hyponatremia is a prevalent electrolyte disorder in hospitalized patients indicative of greater morbidity and mortality. A large‐scale retrospective analysis was conducted to evaluate the incremental burden of hospitalized hyponatremic (HN) versus non‐HN patients in terms of hospital resource utilization, costs, and hospital readmissions in the real‐world setting.METHODS:HN patients (≥18 years) were selected from the Premier Hospital Database between January 1, 2007 and March 31, 2010 and matched to a non‐HN control cohort using propensity score matching. Bivariate and multivariate statistics were employed to evaluate the differences in healthcare resource utilization, costs, and hospital readmissions between patient cohorts.RESULTS:Among the matched patient cohorts, length of stay (LOS) (8.8 ± 10.3 vs 7.7 ± 8.5 days, P < 0.001), hospital admission costs ($15,281 ± $24,054 vs $13,439 ± $22,198, P < 0.001), intensive care unit (ICU) LOS (5.5 ± 7.9 vs 4.9 ± 7.1 days, P < 0.001), and ICU costs ($8525 ± $13,342 vs $7597 ± $12,695, P < 0.001) were greater for the HN versus non‐HN cohort, as were hospital readmission rates 30 days postdischarge. Multivariate regressions further demonstrated that hyponatremia was associated with an increase of 10.9% for LOS, 8.2% for total hospitalization costs, 10.2% for ICU LOS, and 8.9% for ICU costs. Additionally, after multivariate adjustment, hyponatremia was associated with a 15.0% increased chance for hospital readmission 30 days postdischarge (P < 0.0001).CONCLUSIONS:Hyponatremia is an independent predictor of increased hospitalization LOS and cost, ICU admission and cost, and 30‐day hospital readmission, and therefore represents a potential target for intervention to reduce healthcare expenditures for a large population of hospitalized hyponatremic patients. Journal of Hospital Medicine 2012; © 2012 Society of Hospital Medicine

show abstract

Characterization and Prognostic Value of Persistent Hyponatremia in Patients With Severe Heart Failure in the ESCAPE Trial

Cited by 312 publications

References 25 publications

Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart failure

Hyponatremia as predictor of worse outcome in real world patients admitted with acute heart failure

Transplante de células da medula óssea na insuficiência cardíaca chagásica: relato da primeira experiência humana

Evaluation of incremental healthcare resource burden and readmission rates associated with hospitalized hyponatremic patients in the US

Contact Info

Product

Resources

About