Characterization and prevalence of extraintestinal manifestations in a cohort of patients with inflammatory intestinal disease in Medellin, Colombia

Baños, Fabián Juliao; Arrubla, Mateo; Osorio, Laura; Camargo, Joselyn; Londoño, J. Gonzalez; Cáceres, Camilo; Carvajal, Jhon; Mosquera-Klinger, Gabriel; Donado, Jorge

doi:10.1016/j.gastre.2020.07.015

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…When we considered UC, CD, or IBD-U separately, pooled prevalence of PSC was 2.47% (95% CI 1.92%-3.08%; I 2 =99.2%, p<0.0001) in 43 studies containing 566,178 patients with UC, 10,11,[19][20][21][22][23][24][25][26][27][28][29][31][32][33]36,[40][41][42]44,45,[47][48][49][50]52,[56][57][58][59][60][61]63,66,[68][69][70]72,74,[78][79][80] 0.96% (95% CI 0.69%-1.28%; I 2 =91.7%, p<0.0001) in 28 studies recruiting 156,943 patients with CD, 10,22,24,29,30,32,33,…”

Section: Pooled Prevalence Of Psc In Patients With Ibdmentioning

confidence: 99%

“…10,63,80 The OR in patients with UC, versus patients with CD, in 25 studies that reported prevalence in both UC and CD within the same study population, was 1.69 (95% CI 1.24-2.29), with moderate heterogeneity (I 2 =66.5%, p<0.0001), but no funnel plot asymmetry (Egger test, p=0.36). 10,22,24,29,32,33,36,41,[47][48][49][50]52,56,58,59,61,63,66,69,72,74,[78][79][80] In patients with IBD-U, versus UC, it was 3.27 (95% CI Seventeen studies reported data separately in patients with UC 11,19,45,47,49,50,56,57,60,63,66,69,70,72,74,78,80 and 13 in CD, 37,39,…”

Section: Pooled Prevalence Of Psc In Patients With Ibdmentioning

confidence: 99%

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Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

et al. 2021

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Section: Pooled Prevalence Of Psc In Patients With Ibdmentioning

confidence: 99%

Section: Pooled Prevalence Of Psc In Patients With Ibdmentioning

confidence: 99%

Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

et al. 2021

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Beyond the Gut: Extraintestinal Manifestations of Inflammatory Bowel Disease in Children and Adolescents

Vergara Espitia,

Mora Quintero,

De la Hoz Valle

et al. 2024

Rev. colomb. Gastroenterol.

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Antecedentes: las manifestaciones extraintestinales (MEI) son comunes en niños y adultos y su presencia se asocia con mayor gravedad en la enfermedad inflamatoria intestinal (EII). En pediatría, los estudios son escasos en Latinoamérica y no existen en Colombia. Objetivo: describir la prevalencia de las MEI en niños con EII y las características demográficas, clínicas y bioquímicas asociadas. Metodología: estudio retrospectivo de pacientes diagnosticados con EII de inicio pediátrico entre 2007 y 2022 atendidos en una institución en Bogotá. Se realizó un análisis descriptivo y en los grupos con y sin MEI se compararon variables clínicas y bioquímicas por medio de la prueba exacta de Fisher, T de Student y U de Mann-Whitney. Resultados: de 71 casos confirmados, el 45 % tenía colitis ulcerativa típica, el 27 % enfermedad de Crohn, el 7 % colitis ulcerativa atípica, el 1,4 % Crohn colónico y el 20 % EII no clasificable. 13 pacientes (18 %) presentaron al menos una MEI, y las mucocutáneas fueron las más frecuentes (58 %). El lapso desde el inicio de los síntomas hasta el diagnóstico fue mayor en el grupo MEI (13,2 años frente a 10,2 años; p = 0,02). La diarrea nocturna, la hiporexia y la pérdida de peso fueron más frecuentes en niños con MEI. El grupo MEI mostró niveles más bajos de hemoglobina, más elevados de velocidad de sedimentación globular y recibieron biológicos con mayor frecuencia (38 % frente a 23 %, p = 0,2). Conclusiones: La frecuencia de MEI en esta serie es similar a lo reportado en la literatura; su presencia se asocia con una mayor gravedad de la enfermedad, mayor frecuencia de uso de biológicos y mayor tiempo de diagnóstico de la EII.

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The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

Chiang

Chen

et al. 2022

IJERPH

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Patients with inflammatory bowel disease (IBD) have a greater frequency of ocular extra-intestinal manifestations (O-EIMs) than the general population, while Crohn’s disease (CD) and ulcerative colitis (UC) have inconsistent prevalence, according to previous studies. This study aimed to examine the prevalence of O-EIMs in CD and UC, respectively. We systemically reviewed O-EIMs and IBD across several online databases. Inclusion criteria are as follows: (1) observational studies examining the association between O-EIMs and IBD, such as cross-sectional, case–control, or cohort studies; (2) human and adult individuals; and (3) with case and control groups consisting of patients with and without O-EIMs, respectively. Patients under the age of 18 or any study on pediatric IBD will be excluded. The prevalence of uveitis in adults was determined by 21 studies comprising 190,941 individuals with IBD, including 62,874 CD and 128,067 UC. The pooled analysis revealed significantly increased odds of uveitis in patients with CD than with UC (pooled odd ratio (OR) 1.603, 95% confidence interval 1.254–2.049). The subgroup analysis revealed that European populations had significantly higher odds of developing uveitis and episcleritis in patients with CD than UC (pooled OR 1.683 and 2.401, respectively). Although O-EIMs may be the prodrome of IBD, no consistent finding was obtained as a result of the high heterogeneity from the two included studies. This meta-analysis indicates the significantly increased odds of uveitis in adults with CD than those with UC. In subgroup analysis, European with CD seemed to have higher odds of uveitis and episcleritis than those with UC. Nonetheless, the link between O-EIMs and IBD remained unclear.

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Characterization and prevalence of extraintestinal manifestations in a cohort of patients with inflammatory intestinal disease in Medellin, Colombia

Cited by 3 publications

References 27 publications

Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Prevalence of Primary Sclerosing Cholangitis in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Beyond the Gut: Extraintestinal Manifestations of Inflammatory Bowel Disease in Children and Adolescents

The Prevalence of Ocular Extra-Intestinal Manifestations in Adults Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

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