Characterization and Preparation of Calcium Phosphate Model Toothpaste for Tooth Enamel Remineralization

Abstract

Calcium phosphates are excellent biomaterial for hard tissue regeneration and replacement. Recently, nanohydroxylapatite (HAp) has been intensively studied as remineralization agent for tooth enamel protection and remineralization. In this research, we developed model toothpaste composition, determined viscosity and investigated weather different processed – spray-dried (spCDHAp), lyophilized (lyoCDHAp), wet precipitated (paste-like consistence, pCDHAp) – calcium deficient hydroxyapatite (CDHAp) affect bovine tooth enamel remineralization. Model toothpastes components were CDHAp, 2-hydroxyethylcelluloce, glycerol and water. Viscosity varied from 2.5 to 40 Pa∙s. Model toothpastes with 20 wt% CDHAp showed thixotropic behaviour, thereby we examined them as potential tooth remineralization pastes. After in vitro remineralization enamel surface changes were detected, the texture of demineralized surface and bundles of HAp crystals were not observed. It was suggested, that new calcium phosphate layer was formed on the enamel. In conclusion, CDHAp is very promising material for enamel regeneration, but different pretreatment of CDHAp (resulting as different morphology of agglomerates) did not give distinctive remineralization results.

A novel application of nano eggshell/titanium dioxide composite on occluding dentine tubules: an in vitro study

“…Over the last decades, the oral care industry have witnessed proliferation of different occlusion materials for treating DH. Among these materials, the use of potassium oxalates, 5 sodium fluoride, 6 strontium salt, 2 amorphous calcium phosphate containing casein phosphopeptide; 7 calcium glycerophosphate, 8 and calcium carbonates (mainly as abrasive agents) 9 have gain significant interest as an occlusion materials. Although the aforementioned occlusion materials have been reported to provide some relief to patients, the dentine tubules occluded by some of these materials are reported to be superficial with limited infiltration depth-which could be readily re-exposed in an acidic environment.…”

Evaluation of the Occluding Characteristics of Nanosized Eggshell/Titanium Dioxide with or without Saliva

“…11,13 At the first line of at-home therapy for DH management, the use of occluding agents is often recommended for effective treatment. 14 Several different occluding agents such as potassium oxalates, 15 sodium fluoride and sodium monofluorophosphate, 12 strontium salt, 16 amorphous calcium phosphate containing casein phosphopeptide, 17 and calcium glycerophosphate 18 have been widely utilized in desensitizing paste for their dentine tubule occluding capabilities. Still, the effectiveness of the aforementioned occluding agents will depend on the flow of saliva.…”

Remineralization Potential of a Modified Eggshell–Titanium Composite-Scanning Electron Microscope Study

“…Furthermore, occluding agents such as potassium oxalate, 7 sodium fluoride, 8 strontium salt, 1 amorphous calcium phosphate containing casein phosphopeptide, 9 and calcium glycerophosphate 10 have been widely utilized in desensitizing paste for their dentin tubule occluding capabilities. However, the tubules occluded by some of these materials are reported to be superficial with limited infiltration depth.…”