Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of <i>Acacia mangium</i> and <i>Larix gmelinii</i>

Chen, X.; Xiong, Jia; He, Qiwei; Wang, F.

doi:10.1155/2019/4793047

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…More recently, PACs have also been proposed as viable alternatives for the replacement of synthetic food grade antioxidant [ 12 , 13 ] and antimicrobial [ 14 ] agents. In addition, PACs have also been reported for their beneficial properties for human health, more specifically, in the inhibition of enzymes related to high blood pressure [ 15 ] and carbohydrate metabolism [ 16 , 17 , 18 ], as well as anti-cancer [ 19 , 20 ] and anti-inflammatory activities [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Tuning of Proanthocyanidin Extract’s Composition through Quaternary Eutectic Solvents Extraction

et al. 2020

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Currently available proanthocyanidins extraction methods rely on dedicated crops and have low specificity and yield which limits their industrial application. Consequently, the development of novel methodologies and the use of sustainable sources is of great importance. Eutectic solvents have been proposed has good alternatives for conventional solvents due to their low price, easiness of preparation, biocompatibility and ability of being custom made to a specific application. Herein the effective extraction of proanthocyanidins from grape pomace and the possibility of tuning the extract’s characteristics such as mean degree of polymerization and galloylation percentage is explored by means of varying the composition of a quaternary eutectic solvent composed by choline chloride, glycerol, ethanol and water. It was found that mean degree of polymerization values can vary from 6.0 to 7.37 and galloylation percentage can vary from 32.5% to 47.1% while maintaining extraction yield above 72.2 mg of proanthocyanidins per g of biomass. Furthermore, the increase of temperature up to 100 °C has showed a significant effect on the extraction yield being possible to increase it by 238% when compared to the conventional extraction method.

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Section: Introductionmentioning

confidence: 99%

Tuning of Proanthocyanidin Extract’s Composition through Quaternary Eutectic Solvents Extraction

et al. 2020

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“…It has been reported that α-glucosidase inhibitors can effectively delay and alleviate the time and progression of postprandial blood glucose elevation in diabetic patients; therefore, studying the activity of α-glucosidase inhibitors can help control the development of diabetes and the occurrence of complications. [29,30].…”

Section: Resultsmentioning

confidence: 99%

Extraction, Purification, and Biological Activities of Polysaccharides from Branches and Leaves of Taxus cuspidata S. et Z.

et al. 2019

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Taxus cuspidata S. et Z. is an excellent natural source of bioactive polysaccharides and has various biological activities. The objective of this study was to evaluate the effect of antidiabetic and antitumor activities of polysaccharides from Taxus cuspidata branches and leaves (TCBL) and to determine the optimum extraction technology of TCBL using a low-temperature and high-efficiency enzyme and ultrasound-assisted coupled extraction (EUCE) method. Optimal technology parameters were determined as follows: an extraction temperature of 51 °C, an extraction time of 33 min, a ratio of material to liquid of 1:19 (g:mL), and an enzyme concentration of 0.10 mg·mL−1. Under the optimized conditions, the polysaccharide yield from TCBL obtained by EUCE was 4.78% ± 0.18%. The four purified polysaccharides (Pe1, Pe2, Pe3, Pe4) from TCBL are mainly composed of arabinose, galactose, glucose, a small amount of xylose, and mannose. This composition was assessed by HPIC analysis. The antidiabetic activity and antitumor activity of polysaccharides from TCBL were assayed in vitro. Among the four purified polysaccharides from TCBL, purified Pe4 had the highest inhibitory capacity against α-glucosidase, and its IC50 value was 123.0 µg·mL−1. Pe1 had the highest antitumor capacity against MCF7 cells and HepG2 cells, with IC50 values of 169.0 and 132.0 µg·mL−1. Pe4 had the highest antitumor effect on human cervical cancer cells (Hela), and its IC50 value was 89.9 µg·mL−1. Pe4 polysaccharide demonstrated a good α-glucosidase inhibitory activity and antitumor capacity against Hela cells. Therefore, Pe4 polysaccharide from TCBL is a beneficial source of potential inhibitors of type II diabetes and human cervical cancer activity.

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“…α-Glucosidase inhibitors delay and alleviate the time and progression of a diabetic patient's postprandial blood glucose elevation effectively; thus α-glucosidase inhibitors may make great contribution in treating diabetes and the occurrence of complications (Jiang et al 2017b;Chen et al 2019).…”

Section: Antidiabetic Activitiesmentioning

confidence: 99%

Extraction, purification, and biological activities of flavonoids from branches and leaves of Taxus cuspidata S. et Z.

Jiang

Zhao

Xiong

et al. 2021

BioRes

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The optimal operational and process parameters were determined for the enzymatic hydrolysis and ultrasound-assisted extraction (EHUE) method of flavonoids extracted from Taxus cuspidata branches and leaves (TCBL), and the biological activity of obtained flavonoids was evaluated. According to single factor and central composite design experiments, the optimum key experimental parameters for EHUE were that pectinase enzyme concentration was 0.10 mg·mL-1, enzymatic hydrolysis temperature was 48 °C, and enzymolysis time was 39 min. The yield of flavonoids from TCBL under the optimized conditions was 5.23% ± 0.18%. Four purified flavonoid compounds from TCBL extract were identified as 1) (E)-1-methoxy-2-O-(p-coumaroyl)-myo-inositol, 2) catechin, 3) epicatechin, and 4) quercetin-3-O-glucoside. Among the 4 compounds, compounds 2 and 3 showed higher antioxidant capacities, α-amylase, and α-glucosidase inhibitory activities. The statistical analysis showed that epicatechin and catechin were potent antioxidants and active agents for inhibiting type II diabetes. In addition, all 4 compounds exerted clear antitumor activity against MCF-7, Hela, and HepG2 cells. Especially, compound 4 had highest antitumor capacity against MCF-7 and Hela, while compound 1 was best at suppressing the proliferation of HepG2 cells.

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Characterization and Potential Antidiabetic Activity of Proanthocyanidins from the Barks of Acacia mangium and Larix gmelinii

Cited by 6 publications

References 23 publications

Tuning of Proanthocyanidin Extract’s Composition through Quaternary Eutectic Solvents Extraction

Tuning of Proanthocyanidin Extract’s Composition through Quaternary Eutectic Solvents Extraction

Extraction, Purification, and Biological Activities of Polysaccharides from Branches and Leaves of Taxus cuspidata S. et Z.

Extraction, purification, and biological activities of flavonoids from branches and leaves of Taxus cuspidata S. et Z.

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