Abstract:that the C-terminus is involved in channel gating. The mutation E2117D slowed the inactivation rate 8-fold. We made heteromeric channels in HEK cells by co-transfecting with high and low conductance mutants. This created active channels with two new unitary conductances indicating that pore formation occurs at the subunits' interface. The number of new conducting states supports the trimer structure as revealed by Cryo EM. This is the first demonstration of functional heteromers of Piezo channels. Heteromeric … Show more
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