Characterization and Physical Stability of Spray Dried Solid Dispersions of Probucol and PVP-K30

Enhanced Bioavailability of Probucol Following the Administration of Solid Dispersion Systems of Probucol-Polyvinylpyrrolidone in Rabbits

“…11) Thybo et al reported on the characterization and physical stability of spray-dried solid dispersions of probucol and PVP K30. 12) We found that in solid dispersion systems of probucol and PVP prepared by the coprecipitation method, 13,14) probucol dissolution was markedly increased. 8) Although probucol has been used in the treatment of hypercholesterolemia, the pharmacokinetics and pharmacodynamics of the drug are still unknown.…”

The slow molecular dynamics in amorphous probucol

“…1), molecular weight MW = 516.844 g mol À1 , CAS [23,288-49-5], displays two polymorphic forms [8]; the most stable has a melting point in the vicinity of T m = 125 C [8][9][10]. Our probucol samples were from Sigma-Aldrich, product n P9672, and were used without further purification.…”

Amorphization of Molecular Liquids of Pharmaceutical Drugs by Acoustic Levitation

“…In at least two of the cases in this study, namely, Probucol and Ibuprofen, amorphous forms of the drugs have previously been produced by spray drying and mixing with a stabilizing agent. Although Probucol rapidly crystallizes from saturated solutions of ethanol or acetone into one of two polymorphs [25], an amorphous form of the drug has been stabilized by mixing it with a hydrophilic polymer and spray drying [26]. Similarly, Ibuprofen readily crystallizes from an ethanol solution [27], however, a stabilized amorphous form of this drug has also been obtained by cospraying with mesoporous submicron particles to yield an enhanced dissolution rate [28].…”