Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain

Kim, D. K.; Zhang, Y.; Kehr, Ján; Klason, Tomas; Bjelke, Börje; Muhammed, Mamoun

doi:10.1016/s0304-8853(00)01255-5

Cited by 316 publications

(174 citation statements)

References 10 publications

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“…Superparamagnetic particles change the local rate at which protons decay from their excited state to the ground state. When biocompatible dextran-or starch-coated particles selectively bind to healthy or diseased cells, they generate a local magnetic dipole in the large field of the MRI setup which, by a change in the local proton relaxation time, is at the basis of the imaging contrast between the different types of cells (Lawaczeck et al 1997;Kim et al 2001aKim et al , 2001bKim et al , 2003. There is also a size effect: for example, nanoparticles with diameters of ca 30 nm or more are rapidly collected by the liver and spleen, while particles with sizes of ca 10 nm or less are not so easily recognized.…”

Section: Mri Contrast Enhancementmentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

496

555

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This review describes recent advances in the handling and manipulation of magnetic particles in microfluidic systems. Starting from the properties of magnetic nanoparticles and microparticles, their use in magnetic separation, immuno-assays, magnetic resonance imaging, drug delivery, and hyperthermia is discussed. We then focus on new developments in magnetic manipulation, separation, transport, and detection of magnetic microparticles and nanoparticles in microfluidic systems, pointing out the advantages and prospects of these concepts for future analysis applications.

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Section: Mri Contrast Enhancementmentioning

confidence: 99%

Magnetic bead handling on-chip: new opportunities for analytical applications

Gijs

2004

Microfluid Nanofluid

496

555

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“…The synthesis of biocompatible superparamagnetic materials has long been of interest in biomedical applications including magnetic resonance imaging for clinical diagnosis, magnetic drug targeting, hyperthermia anti-cancer strategy, and enzyme immobilization (Kim et al, 2001;Reynolds et al, 2000;Lubbe et al, 1996;Bergemann et al, 1999;Chan et al, 1993;Jordan et al, 1999;Dyal et al, 2003). Entrapment techniques using liposomes, alginate and some other biopolymers are usually applied for different clinical procedures such as drugs release, hyperthermia or for local contrast enhancement in MR imaging.…”

Section: Introductionmentioning

confidence: 99%

Ca alginate as scaffold for iron oxide nanoparticles synthesis

Finotelli

Sampaio

Morales

et al. 2008

Braz. J. Chem. Eng.

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-Recently, nanotechnology has developed to a stage that makes it possible to process magnetic nanoparticles for the site-specific delivery of drugs. To this end, it has been proposed as biomaterial for drug delivery system in which the drug release rates would be activated by a magnetic external stimuli. Alginate has been used extensively in the food, pharmaceutical and biomedical industries for their gel forming properties in the presence of multivalent cations. In this study, we produced iron oxide nanoparticles by coprecipitation of Fe(III) and Fe(II). The nanoparticles were entrapped in Ca alginate beads before and after alginate gelation. XRD analysis showed that particles should be associated to magnetite or maghemite with crystal size of 9.5 and 4.3 nm, respectively. Studies using Mössbauer spectroscopy corroborate the superparamagnetic behavior. The combination of magnetic properties and the biocompatibility of alginate suggest that this biomaterial may be used as biomimetic system.

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“…In MRI, magnetic materials such as gadolinium chelates and magnetic nanoparticles are often used (21)(22)(23) to enhance image contrast. The magnetic nanoparticles are passivated by biocompatible coatings such as dextrin, citrate, polystyrene/divinylbenzene, and elemental gold.…”

mentioning

confidence: 99%

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

Bouchard

Anwar

Liu

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

171

127

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Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.dual-modality imaging ͉ ferromagnetic nanoparticle ͉ molecular imaging ͉ MRI contrast ͉ photoacoustic tomography W e have synthesized nanoparticles for dual-modality (1-7)MRI and photoacoustic tomography (PAT). The incorporation of MRI and PAT into a single probe offers the unique possibility of combining the complementary strategies of contrastbased volume imaging and edge detection. Our nanoconstruct consists of zero-valence ferromagnetic cobalt (Co) particles (8) with a gold (Au) coating for biocompatibility and a unique shape rendering increased optical absorption over a broad range of frequencies (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19). This research theme follows the rapid developments in nanotechnology, diagnostic radiology, and targeted molecular imaging (20), whereby nanoparticulate contrast agents, with the desirable properties of high chemical specificity, biocompatibility, and a reasonable half-life, are administered within a specific region of interest. In nanoparticle-based imaging studies, higher particle concentrations lead to better signal-to-noise contrasts, but this also poses a tradeoff with the toxicity. Therefore, one of the most important parameters when developing particle-based contrast is the safest and lowest nanoparticle concentration that offers sufficient contrast sensitivity.In MRI, magnetic materials such as gadolinium chelates and magnetic nanoparticles are often used (21-23) to enhance image contrast. The magnetic nanoparticles are passivated by biocompatible coatings such as dextrin, citrate, polystyrene/divinylbenzene, and elemental gold. These coatings also detoxify the particles, resulting in enhanced lifetimes in vivo. Typical examples of magnetic nanoparticulate core-shell configurations include magnetitedextrin, magnetite-silica (24) and iron-gold (25).Laser-based PAT (9-19) is a hybrid imaging modality [see supporting information (SI) Fig. S1]. It uses a pulsed laser source to illuminate a biological sample. Light absorption by the tissue results in a transient temperature rise on the order of 10 mK. The rapid thermoelastic expansion excites ultrasonic waves that are measured by using broadband ultrasonic transducers conformally arranged around the sample. Finally, a modif...

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Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain

Cited by 316 publications

References 10 publications

Magnetic bead handling on-chip: new opportunities for analytical applications

Magnetic bead handling on-chip: new opportunities for analytical applications

Ca alginate as scaffold for iron oxide nanoparticles synthesis

Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles

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