Characterization and Molecular Docking of Cinnamic Acid Derivatives: Potential Inhibitors of Cyclooxygenase Enzymes
SAMUEL J BUNU,
DEGHINMOTEI ALFRED-UGBENBO,
OYEINTONBARA MIEDIEGHA
et al.
Abstract:Objective: The pathology of every disease passes through the inflammation stage; hence, the design and optimization of potential lead compounds as anti-inflammatory agents is still a significant part of medicinal chemistry globally.
Methods: In this study, we designed, synthesized, and characterized some cinnamic acid derivatives and performed molecular docking of the derivatives on the human cyclooxygenase-1 (COX-1) enzyme.
Results: The elemental analysis showed the presence of different functional groups. Mo… Show more
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