Characterization and modeling of a microfluidic dielectrophoresis filter for biological species

Li, H.; Zheng, Yanan; Akin, Demir; Bashir, Rashid

doi:10.1109/jmems.2004.839124

Cited by 84 publications

(75 citation statements)

References 24 publications

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“…Adjusting the medium conductivity and operating frequency can be used to maximize the particle polarization factor. It should be noted that, though the results in this papers are from simulations and haven't been confirmed by rigorous experiments, they are based on the modeling environment confirmed by our experiments of dielectrophoretic trapping described in (Li et al, 2005) and should be capable of being a general guide for the micro-fluidic dielectrophoretic device design.…”

Section: Resultsmentioning

confidence: 86%

“…We have previously reported experimental results and finite element modeling of the holding forces for both positive and negative dielectrophoretic traps on microfabricated interdigitated electrodes within a microfluidic device (Li et al, 2005). This device was fabricated by KOH anisotropically etching a thin (∼12 µm) micro-channel into single crystalline silicon substrate and the channel was closed with a glass cover using anodic bonding.…”

Section: Introductionmentioning

confidence: 99%

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On the Design and Optimization of Micro-Fluidic Dielectrophoretic Devices: A Dynamic Simulation Study

Bashir

2004

Biomedical Microdevices

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Abstract. Microfabricated interdigitated electrode array is a convenient form of electrode geometry for dielectrophoretic trapping of biological particles within micro-fluidic biochips. We have previously reported experimental results and finite element modeling of the holding forces for both positive and negative dielectrophoretic traps on microfabricated interdigitated electrodes within a microfluidic biochip fabricated in silicon with a 12 µm deep chamber and anodic-bonded glass cover. Based on these prior studies, we present in this paper a dynamic study to investigate the stopping capability of dielectrophoretic devices with limited electrode teeth. Simulation results on the issues of design and optimization of the dielectrophoretic devices are also presented and discussed in detail. Simulation results show that the maximum particle stopping distance in a specific device is very sensitive to the chamber height due to the near-electrode nature of DEP force. The relationship between maximum stopping distance and the applied voltage is presented, and the electrode spacing is found to be important in designing the electrode geometry. The spacing should be no less than the chamber height in order to efficiently capture the particles in a relatively short range at a given applied voltage and flow rate.

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Section: Resultsmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

On the Design and Optimization of Micro-Fluidic Dielectrophoretic Devices: A Dynamic Simulation Study

Bashir

2004

Biomedical Microdevices

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“…Dielectrophoresis (DEP) is one of the most effective techniques for interacting with any polarizable particle using easily generated electric fields [5,6]. Extensive studies employing various DEP devices have demonstrated the ability to precisely manipulate single cells with sizes varying from over 10 microns (mammalian cells) down to about 1 micron (bacteria) [7][8][9]. However, applying DEP to capture virus particles remains difficult due to their much smaller size (tens to hundreds of nanometers).…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, the hydrodynamic force to carry the particles with flow (i.e. drag force F Drag ) is directly proportional to the radius of the particle with (3) where η is the dynamic viscosity, k is a factor accounts for the wall effects, and ʋ is the linear flow rate (flow velocity) [8]. In addition, Brownian motion of a particle increases as the particle size is reduced.…”

Section: Introductionmentioning

confidence: 99%

Manipulation of bacteriophages with dielectrophoresis on carbon nanofiber nanoelectrode arrays

et al. 2013

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This work describes efficient manipulation of bacteriophage virus particles using a nanostructured dielectrophoresis (DEP) device. The non-uniform electric field for DEP is created by utilizing a nanoelectrode array (NEA) made of vertically aligned carbon nanofibers (VACNFs) versus a macroscopic indium tin oxide electrode in a "points-and-lid" configuration integrated in a microfluidic channel. The capture of the virus particles has been systematically investigated versus the flow velocity, sinusoidal AC frequency, peak-to-peak voltage, and virus concentration. The DEP capture at all conditions is reversible and the captured virus particles are released immediately when the voltage is turned off. At the low virus concentration (8.9×10 4 pfu·ml −1 ), the DEP capture efficiency up to 60% can be obtained. The virus particles are individually captured at isolated nanoelectrode tips and accumulate linearly with time. Due to the comparable size, it is more effective to capture virus particles than larger bacterial cells with such NEA based DEP devices. This technique can be potentially utilized as a fast sample preparation module in a microfluidic chip to capture, separate, and concentrate viruses and other biological particles in small volumes of dilute solutions in a portable detection system for field applications.

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“…The classical DEP has been expanded to travelling wave DEP in order to get high throughput cell manipulation without external liquid pumping [2], CMOS DEP in order to achieve parallel manipulation of large number of cells [3], and laser induced DEP by optically programmable electrodes [4]. Microfabricated interdigitated electrode array was introduced previously [5] for application of separating two populations of particles pumped across the electrode array, one population of particles having positive dielectrophoresis and another having negative dielectrophoresis.The above approaches are all based on fixed electrodes arrangement.A concept of moving dielectrophoresis electrode (MDEP) is introduced based on microelectromechanical systems …”

mentioning

confidence: 99%

A Concept of Moving Dielectrophoresis Electrodes Based on Microelectromechanical Systems (Mems) Actuators

Li¹,

Uttamchandani²

2008

PIER Letters

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Abstract-A concept of moving dielectrophoresis electrodes (MDEP) based on Microelectromechanical Systems (MEMS) actuators is introduced in this letter.An example design of tuneable dielectrophoresis filter is presented. Finite Element Analysis of the electrostatic field of the tuneable filter has been conducted. Results show that the trapping force can be adjusted by actuating the MEMS actuators.The principle of the dielectrophresis (DEP) is based on polarization of the dielectric particles under electrostatic field. Polarized dielectric particles can be moved toward the direction of the electric field gradient. Examples of polarized objects include dielectric materials, metallic particles, and many biological objects, such as nucleic acids, proteins, cells, and virus. DEP has been proven to be a powerful technique to perform sample sorting, trapping, manipulation, and concentration [1]. The classical DEP has been expanded to travelling wave DEP in order to get high throughput cell manipulation without external liquid pumping [2], CMOS DEP in order to achieve parallel manipulation of large number of cells [3], and laser induced DEP by optically programmable electrodes [4]. Microfabricated interdigitated electrode array was introduced previously [5] for application of separating two populations of particles pumped across the electrode array, one population of particles having positive dielectrophoresis and another having negative dielectrophoresis.The above approaches are all based on fixed electrodes arrangement.A concept of moving dielectrophoresis electrode (MDEP) is introduced based on microelectromechanical systems

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Characterization and modeling of a microfluidic dielectrophoresis filter for biological species

Cited by 84 publications

References 24 publications

On the Design and Optimization of Micro-Fluidic Dielectrophoretic Devices: A Dynamic Simulation Study

On the Design and Optimization of Micro-Fluidic Dielectrophoretic Devices: A Dynamic Simulation Study

Manipulation of bacteriophages with dielectrophoresis on carbon nanofiber nanoelectrode arrays

A Concept of Moving Dielectrophoresis Electrodes Based on Microelectromechanical Systems (Mems) Actuators

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