Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes

Garms, Bruna Cambraia; Borges, Felipe Azevedo; Santos, R. E.; Nigoghossian, Karina; Miranda, Matheus Carlos Romeiro; Miranda, Ian; Daltro, Paula Braga; Scarpari, Sérgio L.; Giagio, R. J.; Barros, Natan Roberto de; Alarcon, Kaila Medina; Drago, Bruno C.; Gemeinder, José Lúcio Pádua; Oliveira, Bruno Henrique de; Nascimento, Valéria M. G.; Loffredo, Augusto Villela; Herculano, Rondinelli Donizetti

doi:10.9734/bjpr/2017/31614

Cited by 18 publications

(6 citation statements)

References 25 publications

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“…The outcomes obtained are similar to those reported by Garms et al 62 They incorporated moxifloxacin in the NRL membranes. So far, it was observed that the mechanical resistance obtained for this biomaterial is suitable for biomedical applications once the Young’s modulus (0.84 MPa) and rupture tension (1.12 MPa) are in accordance with the values reported in the literature associated with NRL application in human skin (0.01 to 50 MPa for Young’s modulus and 1 to 40 MPa for rupture tension).…”

Section: Discussionsupporting

confidence: 88%

“…These results are in agreement with other works, which indicated the drug structural integrity (sodium diclofenac, glycerol, moxifloxacin, ciprofloxacin, and ketoprofen) after incorporation into the NRL. 37,38,41,62,67 Therefore, it can be concluded that the characteristic bands of IBF and the NRL were preserved in the FTIR spectrum of the IBF-NRL membrane, as it was not observed the appearance of new bands or the disappearance of others.…”

Section: Discussionmentioning

confidence: 94%

“…It was possible to verify in the NRL spectrum (blue line) the characteristic bands of poly ( cis -1,4-isoprene) such as 2960–2852 cm −1 (CH 2 symmetric and CH 3 asymmetric stretching), 1446 cm −1 and 1375 cm −1 (CH 2 and CH 3 deformation), 1662 cm −1 (C=C stretching) and 835 cm −1 (=CH out of the plane bending). 62…”

Section: Resultsmentioning

confidence: 99%

“…75,76 In addition, the 3D IBF particles were dispersed in the form of crystals on the membranes, as reported in other works, which indicates that significant amount of the pharmaceutical assets can be positioned along the membrane surface. 62,77,78 The presence of IBF on the membrane surface suggests that the drug release can occur very quickly in the solutions, giving rise to the burst release effect, which consists of the almost spontaneous release of some fraction of the compound to the external system. Previous studies have also reported that the drugs, which have crystalline structure on the NRL membranes surfaces, have influenced the burst release.…”

Section: Discussionmentioning

confidence: 99%

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Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Lima

Pegorin

Miranda

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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The incorporation of drugs and bioactive compounds in the natural rubber latex (NRL) matrix has been an alternative for the development of transdermal release membranes. Ibuprofen (IBF) is known to be used to treat inflammatory diseases, but when administered orally, high concentrations can cause some adverse problems. In this work, the incorporation of IBF in the NRL membranes was evaluated by physical-chemical, in vitro permeation, hemocompatibility and molecular modeling assays. In addition, the in vitro release profile of IBF in acid and basic media was analyzed during 96 h. The IBF-NRL membrane exhibited the absence of intermolecular bonding that could hinder drug release and presented compatible mechanical properties for applications as a cutaneous adhesive (0.58 and 1.12 MPa to Young’s modulus and rupture tension, respectively). The IBF-NRL system did not present a significant hemolysis degree (1.67%) within 24 h. The release test indicated that in the first hours of the study, 48.5% IBF was released at basic pH and 22.5% at acidic pH, which is characteristic of a burst effect. Then, a stable release profile was observed until the end of the assay, with total IBF release of 60% in alkaline medium and 50% in acidic medium. The drug permeation results indicated that the IBF-NRL membranes can be used for the local skin treatment with permeation of 3.11% of IBF. Dynamic Molecular simulations indicated a pronounced electric dipole in the ionized form of IBF, which suggests a more effective interaction with water, explaining the efficient drug release in alkaline solutions. In general, the results demonstrate that the IBF-NRL membrane has great potential for a new adhesive that can be used for the treatment of inflammatory processes and injuries.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Lima

Pegorin

Miranda

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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“…Figure 4 shows the ketoprofen release as a function of time. The large bolus of drug released before stability is called "burst release" (0-24 h) due to the drug close or adsorbed on the surface of the NRL membrane [27,28].…”

Section: Resultsmentioning

confidence: 99%

Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment

et al. 2017

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Dispersion of hydroxyapatite nanoparticles in natural rubber latex and poly lactic acid based matrices

Cesar

Poli

Piazza

et al. 2022

J of Applied Polymer Sci

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Hydroxyapatite (HAp)‐polymer composite materials are of interest for materials that interface with or substitute bone tissue. HAp nanoparticles (length 290 nm, width 56 nm) synthesized by a wet chemical method were incorporated (5 wt%) into natural rubber latex (NRL), poly lactic acid (PLA) and NRL/PLA (75/25) solvent cast films using three different methods: dry nanoparticles; a dispersion prepared from dry nanoparticles; a dispersion prepared through solvent exchange. Common to all composite materials were an improvement in the contact angle by 10%–13% and a reduction in the elongation at break from 430% to 330%–370%. Furthermore, the method of HAp incorporation influenced the properties of the material with the use of dioxane suspension improving the homogeneity of the films as evidenced from visual appearance and SEM. This led to slower water uptake and higher thermal stability with a shift in the PLA melting peak from 296°C to 334°C when compared to pure polymer and composites with poorly dispersed particle.

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Characterization and Microbiological Application of Ciprofloxacin Loaded in Natural Rubber Latex Membranes

Cited by 18 publications

References 25 publications

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling

Ketoprofen Loaded in Natural Rubber Latex Transdermal Patch for Tendinitis Treatment

Dispersion of hydroxyapatite nanoparticles in natural rubber latex and poly lactic acid based matrices

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