Characterization and in vitro studies on anticancer, antioxidant activity against colon cancer cell line of gold nanoparticles capped with Cassia tora SM leaf extract

Abel, Ezra Elumalai; Poonga, Preetam Raj John; Panicker, Shirly G.

doi:10.1007/s13204-015-0422-x

Cited by 53 publications

(12 citation statements)

References 29 publications

(26 reference statements)

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“…It has been demonstrated before that AuNPs exert in vitro cytotoxicity on several human cancer cells including HepG2 and triple negative breast cancer cells (MDA-MB-231) [ 61 , 62 , 63 ]. Green-synthesized AuNPs from Cassia tora leaf extracts demonstrated the cytotoxic efficacy against colon cancer (Col320) cell lines and not in the normal (Vero) cell lines [ 64 ]. AuNPs from Gymnema sylvestre leaf extracts were also investigated for their antitumor effects against HT-29 cells.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

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Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less harmful treatment strategies. The current study demonstrated the use of Terminalia mantaly (TM) extracts to synthesize AuNPs with enhanced cytotoxic effects. The TM-AuNPs were synthesized at 25 and 70 °C using water (WTM) and methanolic (MTM) extracts of the leaf, root and stem/bark parts of the plant. The TM-AuNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), transmission electron microscopy, energy dispersive X-ray (EDX), selection area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy. Majority of the TM-AuNPs were spherical with a mean diameter between 22.5 and 43 nm and were also crystalline in nature. The cytotoxic effects of TM-AuNPs were investigated in cancer (Caco-2, MCF-7 and HepG2) and non-cancer (KMST-6) cell lines using the MTT assay. While the plant extracts showed some cytotoxicity towards the cancer cells, some of the TM-AuNPs were even more toxic to the cells. The IC50 values (concentrations of the AuNPs that inhibited 50% cell growth) as low as 0.18 µg/mL were found for TM-AuNPs synthesized using the root extract of the plant. Moreover, some of the TM-AuNPs demonstrated selective toxicity towards specific cancer cell types. The study demonstrates the potential of TM extracts to produce AuNPs and describe the optimal conditions for AuNPs using TM extracts. The toxicity of some the TM-AuNPs can possibly be explored in the future as an antitumor treatment.

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Section: Resultsmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

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“…In another study AuNPs targeted to the nucleus, promote cell-cycle arrest, cytokinesis inhibitionwhich then push the cell over to apoptosis [94]. In many instances, AuNPs are used as a delivery system [95] or in conjugation with the therapeutic molecule [96] or maybe even gene to give significantly better toxicity against cancer cells. AuNPs due to their distinctive photo-optical properties have been successfully applied in both photothermal and photodynamic therapy.…”

Section: Gold Nanoparticlesmentioning

confidence: 99%

Role of gold and silver nanoparticles in cancer nano-medicine

Chugh

Sood

Chandra

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

243

119

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Development of nanoparticles (NPs) as a part of cancer therapeutics has given rise to a new field of research - cancer nanomedicine. In comparison to traditional anti-cancer drugs, NPs provide a targeted approach which prevents undesirable effects. In this communication, we have reviewed the role of gold and silver NPs (AgNPs) in the cancer nanomedicine. The preparation of gold NPs (AuNPs) and AgNPs can be grouped into three categories - physical, chemical and biological. Among the three approaches, the biological approach is growing and receiving more attention due to its safe and effective production. In this review, we have discussed important methods for synthesis of gold and AgNPs followed by techniques employed in characterization of their physicochemical properties, such as UV-visible spectroscopy, electron microscopy (TEM and SEM) and size and surface analysis (DLS). The mechanism of formation of these NPs in an aqueous medium through various stages - reduction, nucleation and growth has also been reviewed briefly. Finally, we conclude our review with the application of these NPs as anti-cancer agents and numerous mechanisms by which they render cancer cell toxicity.

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“…Another study demonstrated the cytotoxic efficacy of Cassia tora against colon cancer cell lines. The study revealed that the activity of C. tora at three different doses (25, 50, and 75 μ g/mL) was dose-dependent; the 75 μ g/mL dose showed the highest activity against the colon cancer cell lines [ 108 ]. Green-synthesized AuNPs from Gymnema sylvestre leaf extracts ( G. sylvestre ) were also investigated for their anticancer effects against hepatocellular carcinoma (HepG2) cells.…”

Section: Aunpsmentioning

confidence: 99%

Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents

Rao

Nallappan

Madhavi

et al. 2016

Oxidative Medicine and Cellular Longevity

139

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Cancer is a leading cause of death worldwide. Several classes of drugs are available to treat different types of cancer. Currently, researchers are paying significant attention to the development of drugs at the nanoscale level to increase their target specificity and to reduce their concentrations. Nanotechnology is a promising and growing field with multiple subdisciplines, such as nanostructures, nanomaterials, and nanoparticles. These materials have gained prominence in science due to their size, shape, and potential efficacy. Nanomedicine is an important field involving the use of various types of nanoparticles to treat cancer and cancerous cells. Synthesis of nanoparticles targeting biological pathways has become tremendously prominent due to the higher efficacy and fewer side effects of nanodrugs compared to other commercial cancer drugs. In this review, different medicinal plants and their active compounds, as well as green-synthesized metallic nanoparticles from medicinal plants, are discussed in relation to their anticancer activities.

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Characterization and in vitro studies on anticancer, antioxidant activity against colon cancer cell line of gold nanoparticles capped with Cassia tora SM leaf extract

Cited by 53 publications

References 29 publications

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

Role of gold and silver nanoparticles in cancer nano-medicine

Phytochemicals and Biogenic Metallic Nanoparticles as Anticancer Agents

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