Characterization and in vitro release studies of oral microbeads containing thiolated pectin–doxorubicin conjugates for colorectal cancer treatment

Cheewatanakornkool, Kamonrak; Niratisai, Sathit; Manchun, Somkamol; Dass, Crispin R.; Sriamornsak, Pornsak

doi:10.1016/j.ajps.2017.07.005

Cited by 45 publications

(18 citation statements)

References 41 publications

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“…An annual increase in deaths from colon cancer has been reported in the literature [116]. In men, it is the third most common type of cancer, and in women, the second most common type [120,121]. Conventional treatments, such as chemotherapy and radiotherapy, have considerable disadvantages, as they do not specifically target cancer cells and can cause damage to healthy cells [122].…”

Section: Pectin In the Cancer Treatmentmentioning

confidence: 99%

“…To overcome this restriction, several delivery vehicles have been tried to improve the bioavailability of curcumin, such as polymeric micelles, nanocomplexes, nanoemulsions, liposomes, conjugates, and lipid nanoparticles [123]. Promising drug delivery systems include drug entrapment in polymeric drug carriers, such as hydrogels and nanoparticles [121]. Among the promising curcumin nanocarriers, pectin stands out for crossing the gastrointestinal epithelium effectively and, therefore, bypassing the metabolic restrictions within the gastrointestinal tract [116].…”

Section: Pectin In the Cancer Treatmentmentioning

confidence: 99%

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Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

et al. 2021

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Pectin is a biocompatible polysaccharide with intrinsic biological activity, which may exhibit different structures depending on its source or extraction method. The extraction of pectin from various industrial by-products presents itself as a green option for the valorization of agro-industrial residues by producing a high commercial value product. Pectin is susceptible to physical, chemical, and/or enzymatic changes. The numerous functional groups present in its structure can stimulate different functionalities, and certain modifications can enable pectin for countless applications in food, agriculture, drugs, and biomedicine. It is currently a trend to use pectin to produce edible coating to protect foodstuff, antimicrobial bio-based films, nanoparticles, healing agents, and cancer treatment. Advances in methodology, use of different sources of extraction, and knowledge about structural modification have significantly expanded the properties, yields, and applications of this polysaccharide. Recently, structurally modified pectin has shown better functional properties and bioactivities than the native one. In addition, pectin can be used in conjunction with a wide variety of biopolymers with differentiated properties and specific functionalities. In this context, this review presents the structural characteristics and properties of pectin and information on the modification of this polysaccharide, its respective applications, perspectives, and future challenges.

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Section: Pectin In the Cancer Treatmentmentioning

confidence: 99%

Section: Pectin In the Cancer Treatmentmentioning

confidence: 99%

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

et al. 2021

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“…In the past few years the world has witnessed many new methods in treating cancers1., 2., 3., 4., 5., 6., 7., 8., 9., 10., such as monoclonal antibodies, gene therapy4., 10., photodynamic therapy (PDT), sonodynamic therapy, and photothermal therapy (PTT) 8 . However, cancer therapy is still a big challenge, with the mean survival length of cancer patients only several years.…”

Section: Introductionmentioning

confidence: 99%

Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration

Wei

et al. 2019

Acta Pharmaceutica Sinica B

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To establish an injectable hydrogel containing Prussian blue (PB) nanospheres for photothermal therapy against cancer, PB nanospheres were prepared by one-pot synthesis and the thermosensitive Pluronic F127 was used as the hydrogel matrix. The PB nanospheres and the hydrogel were characterized by shape, particle size, serum stability, photothermal performance upon repeated 808 nm laser irradiation, as well as the rheological features. The effect of the PB nanospheres and the hydrogel were evaluated qualitatively and quantitatively in 4T1 mouse breast cancer cells. The retention, photothermal efficacy, therapeutic effects and systemic toxicity of the hydrogel were assessed in a tumor-bearing mouse model. The PB nanospheres had a diameter of about 150 nm and exhibited satisfactory serum stability, photo-heat convert ability and repeated laser exposure stability. The hydrogel encapsulation did not negatively influence the above features of the photothermal agent. The nanosphere-containing hydrogel showed a phase transition at body temperature and, as a result, a long retention time in vivo . The photothermal agent-embedded hydrogel displayed promising photothermal therapeutic effects in the tumor-bearing mouse model with little-to-no systemic toxicity after peritumoral administration.

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“…Although the nanogels prepared in this study possess an enhanced cyto-killing property based on photothermia and drug release, there is still room for further improvement. First, the encapsulation efficiency and drug-loading capacity of nanogels could be increased, which might be achieved by the formation of polymer-drug conjugates via reversible disulfide [26], ester [27], or hydrazone [28,29] linkages. Second, the cellular uptake efficiency of nanogels could be improved by conjugation of ligands to surface receptors of cancer cells, such as peptides [30] or galactose [31], leading to specific cell recognition and active endocytosis.…”

Section: Discussionmentioning

confidence: 99%

Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy

Chang

Tsai

2018

Polymers

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Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment.

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Characterization and in vitro release studies of oral microbeads containing thiolated pectin–doxorubicin conjugates for colorectal cancer treatment

Cited by 45 publications

References 41 publications

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

Structure and Applications of Pectin in Food, Biomedical, and Pharmaceutical Industry: A Review

Prussian blue nanosphere-embedded in situ hydrogel for photothermal therapy by peritumoral administration

Fabrication of Photothermo-Responsive Drug-Loaded Nanogel for Synergetic Cancer Therapy

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